1
Stuart Kauffman: "Answering Descartes: Beyond Turing"
Stuart Kauffman: "Answering Descartes: Beyond Turing"
DATE: 2013/09/18::
2
The Re-Enchantment of Humanity: Dr. Stuart Kauffman
The Re-Enchantment of Humanity: Dr. Stuart Kauffman
DATE: 2012/02/07::
3
Stuart Kauffman on Beyond Reductionism
Stuart Kauffman on Beyond Reductionism
DATE: 2008/06/03::
4
Biologist and complexity theorist Stuart Kauffman on preadaptations in evolution
Biologist and complexity theorist Stuart Kauffman on preadaptations in evolution
DATE: 2009/07/27::
5
Reinventing the Sacred with Stuart Kauffman part1
Reinventing the Sacred with Stuart Kauffman part1
DATE: 2008/08/18::
6
13. Stuart Kauffman - Beyond Belief 2007
13. Stuart Kauffman - Beyond Belief 2007
DATE: 2011/01/28::
7
Stuart Kauffman Returns to Gund 1/2
Stuart Kauffman Returns to Gund 1/2
DATE: 2012/01/08::
8
Entretien avec Stuart Kauffman
Entretien avec Stuart Kauffman
DATE: 2014/02/03::
9
Stuart Kauffman Returns to Gund 2/2
Stuart Kauffman Returns to Gund 2/2
DATE: 2012/01/08::
10
Innovation Game Changer: Stuart Kauffman, MD (Episode 2)
Innovation Game Changer: Stuart Kauffman, MD (Episode 2)
DATE: 2014/01/23::
11
Stuart Kauffman: Yuk
Stuart Kauffman: Yuk 'n' Yum
DATE: 2009/05/04::
12
Stuart Kauffman - Mind in the Poised Realm
Stuart Kauffman - Mind in the Poised Realm
DATE: 2012/08/24::
13
Stuart Kauffman sets the purpose introduction and agenda setting
Stuart Kauffman sets the purpose introduction and agenda setting
DATE: 2009/07/27::
14
Determinism vs freewill
Determinism vs freewill
DATE: 2013/06/10::
15
Gordon Kaufman on creativity, Liane Gabora and Stuart Kauffman discuss
Gordon Kaufman on creativity, Liane Gabora and Stuart Kauffman discuss
DATE: 2009/07/27::
16
OUBEY - Encounter 8 - Stuart Kauffman (English)
OUBEY - Encounter 8 - Stuart Kauffman (English)
DATE: 2010/11/05::
17
STUART KAUFFMAN - REINVENTING THE SACRED
STUART KAUFFMAN - REINVENTING THE SACRED
DATE: 2013/09/15::
18
Reinventing the Sacred with Stuart Kauffman part2
Reinventing the Sacred with Stuart Kauffman part2
DATE: 2008/08/18::
19
Stuart Kauffman "Beyond Reductionism"
Stuart Kauffman "Beyond Reductionism"
DATE: 2008/01/22::
20
Stuart Kauffman leads off on constraints and creativity (w Gordon Kaufman, Liane Gabora)
Stuart Kauffman leads off on constraints and creativity (w Gordon Kaufman, Liane Gabora)
DATE: 2009/07/22::
21
The 2008-09 Paul Tillich Lecture: The Open Universe and the Sacred
The 2008-09 Paul Tillich Lecture: The Open Universe and the Sacred
DATE: 2014/05/21::
22
Reinventing the Sacred with Stuart Kauffman part3
Reinventing the Sacred with Stuart Kauffman part3
DATE: 2008/08/18::
23
Stuart Kauffman on Leadership
Stuart Kauffman on Leadership
DATE: 2010/10/04::
24
Stuart Kauffman and "WE"
Stuart Kauffman and "WE"
DATE: 2008/05/24::
25
Reinventing the Sacred with Stuart Kauffman part5
Reinventing the Sacred with Stuart Kauffman part5
DATE: 2008/08/18::
26
Reinventing the Sacred with Stuart Kauffman part4
Reinventing the Sacred with Stuart Kauffman part4
DATE: 2008/08/18::
27
Reinventing the Sacred with Stuart Kauffman part10
Reinventing the Sacred with Stuart Kauffman part10
DATE: 2008/08/19::
28
Reinventing the Sacred with Stuart Kauffman part11
Reinventing the Sacred with Stuart Kauffman part11
DATE: 2008/08/19::
29
Reinventing the Sacred with Stuart Kauffman part8
Reinventing the Sacred with Stuart Kauffman part8
DATE: 2008/08/18::
30
Reinventing the Sacred with Stuart Kauffman part7
Reinventing the Sacred with Stuart Kauffman part7
DATE: 2008/08/18::
31
Reinventing the Sacred with Stuart Kauffman part9
Reinventing the Sacred with Stuart Kauffman part9
DATE: 2008/08/18::
32
Reinventing the Sacred with Stuart Kauffman part12
Reinventing the Sacred with Stuart Kauffman part12
DATE: 2008/08/19::
33
Reinventing the Sacred with Stuart Kauffman part6
Reinventing the Sacred with Stuart Kauffman part6
DATE: 2008/08/18::
34
Reinventing the Sacred with Stuart Kauffman part14
Reinventing the Sacred with Stuart Kauffman part14
DATE: 2008/08/19::
35
Reinventing the Sacred with Stuart Kauffman part13
Reinventing the Sacred with Stuart Kauffman part13
DATE: 2008/08/19::
36
Stuart Kauffman
Stuart Kauffman's vision of "WE"
DATE: 2010/10/04::
37
Steve Paulson and Stuart Kauffman: woo woo smoke blowers from Templeton
Steve Paulson and Stuart Kauffman: woo woo smoke blowers from Templeton
DATE: 2012/11/09::
38
Liane Gabora
Liane Gabora's story of improv dance with constraints (w Gordon Kaufman, Stuart Kauffman)
DATE: 2009/07/22::
39
Complex System Impacts on EE (P1)
Complex System Impacts on EE (P1)
DATE: 2010/12/02::
40
Complex System Impacts on EE (P2)
Complex System Impacts on EE (P2)
DATE: 2010/12/02::
41
Complex System Impacts on EE (P3)
Complex System Impacts on EE (P3)
DATE: 2010/11/23::
42
Bekijk de Noorderlicht-aflevering
Bekijk de Noorderlicht-aflevering 'Thuis in het universum'
DATE: 2008/05/05::
43
ISB at Town Hall: Tipping Points in Environment and Climate
ISB at Town Hall: Tipping Points in Environment and Climate
DATE: 2015/03/20::
44
Douglas Adams
Douglas Adams' The Hitchhiker's Guide To The Future. 4/4 CONVERGENCE
DATE: 2014/10/13::
45
epistatic vidsm.mp4
epistatic vidsm.mp4
DATE: 2009/12/01::
46
25 Smartest People Alive | Existive (2014) (1 of 5)
25 Smartest People Alive | Existive (2014) (1 of 5)
DATE: 2014/12/11::
47
How I Became an Atheist
How I Became an Atheist
DATE: 2008/01/26::
48
Can Science Find The Soul?
Can Science Find The Soul?
DATE: 2012/10/17::
49
Emergent Reality - The Sea of Organic Recursion
Emergent Reality - The Sea of Organic Recursion
DATE: 2011/06/15::
50
Dario Simoncini - Il paradigma complesso
Dario Simoncini - Il paradigma complesso
DATE: 2011/02/15::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Stuart Kauffman
Stuart Kauffman.jpg
Stuart Kauffman in April 2010
Born (1939-09-28) September 28, 1939 (age 75)
Website
stuartkauffman.com

Stuart Alan Kauffman (born September 28, 1939) is an American medical doctor, theoretical biologist, and complex systems researcher who studies the origin of life on Earth.

In 1967[1] and 1969[2] Kauffman proposed applying models of random boolean networks to simplified genetic circuits. These were very early models of large genetic regulatory networks, proposing that cell types are dynamical attractors of such networks and that cell differentiation steps are transitions between attractors. Recent evidence strongly suggests that cell types in humans and other organisms are indeed attractors.[3] In 1971 he suggested that the zygote may not access all the cell type attractors in the repertoire of the genetic network's dynamics, hence some of the unused cell types might be cancers.[4] This suggested the possibility of "cancer differentiation therapy", for which some evidence may now be accumulating.[5]

In 1971, Kauffman proposed the self-organized emergence of collectively autocatalytic sets of polymers, specifically peptides, for the origin of molecular reproduction.[6][7] Reproducing peptide, DNA, and RNA collectively autocatalytic sets have now been made experimentally.[8][9] He is best known for arguing that the complexity of biological systems and organisms might result as much from self-organization and far-from-equilibrium dynamics as from Darwinian natural selection. His hypotheses stating that cell types are attractors of such networks, and that genetic regulatory networks are "critical", have found experimental support.[3][10] It now appears that the brain is also dynamically critical.[11]

Education and early career[edit]

Kauffman graduated from Dartmouth in 1960, was awarded the BA (Hons) by Oxford University (where he was a Marshall Scholar) in 1963, and completed a medical degree (M.D.) at the University of California, San Francisco in 1968. After completing his internship, he moved into developmental genetics of the fruitfly, holding appointments first at the University of Chicago, then at the University of Pennsylvania from 1975 to 1995, where he rose to Professor of Biochemistry and Biophysics.[citation needed]

Career[edit]

Kauffman became known through his association with the Santa Fe Institute (a non-profit research institute dedicated to the study of complex systems), where he was faculty in residence from 1986 to 1997, and through his work on models in various areas of biology. These included autocatalytic sets in origin of life research, gene regulatory networks in developmental biology, and fitness landscapes in evolutionary biology. With Marc Ballivet, Kauffman holds the founding broad biotechnology patents in combinatorial chemistry and applied molecular evolution, first issued in France in 1987, in England in 1989, and later in the US.[12]

In 1996, Kauffman started BiosGroup, a Santa Fe, New Mexico-based for-profit company that applied complex systems methodology to business problems. BiosGroup was acquired by NuTech Solutions in early 2003. NuTech was bought by Netezza in 2008, and later by IBM.[citation needed]

From 2004 to 2009 Kauffman held a joint appointment at the University of Calgary in Biological Sciences and Physics and Astronomy. He was also an Adjunct Professor in the Department of Philosophy at the University of Calgary. He is an iCORE (Informatics Research Circle of Excellence) chair and the director of the Institute for Biocomplexity and Informatics. Kauffman was also invited to help launch the Science and Religion initiative at Harvard Divinity School; serving as Visiting Professor in 2009.[citation needed]

In January 2009 Kauffman became a Finland Distinguished Professor (FiDiPro) at Tampere University of Technology, Department of Signal Processing. The appointment ended in December, 2012. The subject of the FiDiPro research project is the development of delayed stochastic models of genetic regulatory networks based on gene expression data at the single molecule level.[citation needed]

In January 2010 Kauffman joined the University of Vermont faculty where he continued his work for two years with UVM's Complex Systems Center.[13] From early 2011 to April 2013, Kauffman was a regular contributor to the NPR Blog 13.7, Cosmos and Culture,[14] with topics ranging from the life sciences, systems biology, and medicine, to spirituality, economics, and the law. Kauffman is also a regular contributor to Edge.org.[15]

In May 2013 Kauffman joined the Institute for Systems Biology, in Seattle Washington. Following the death of his wife, with others, Kauffman cofounded The Elizabeth Kauffman Institute for Transforming Medicine.[16]

In 2014, Kauffman with Samuli Niiranen and Gabor Vattay was issued a founding patent[17] on the poised realm (see below), an apparently new "state of matter" hovering reversibly between quantum and classical realms.[18]

Recognition and awards[edit]

Kauffman held a MacArthur Fellowship between 1987–1992. He also holds an Honorary Degree in Science from the University of Louvain; and was awarded a Gold Medal of the Accademia Lincea in Rome.[citation needed]

Works[edit]

Kauffman is best known for arguing that the complexity of biological systems and organisms might result as much from self-organization and far-from-equilibrium dynamics as from Darwinian natural selection.

Some biologists and physicists working in Kauffman's area reserve judgment on Kauffman's claims about self-organization and evolution. A case in point is the introduction to the 2002 book Self Organization in Biological Systems (ISBN 978-0691116242). Roger Sansom's Ingenious Genes: How Gene Regulation Networks Evolve to Control Development (MIT Press, 2011) is an extended criticism of Kauffman's models.

Borrowing from spin glass models in physics, Kauffman invented "N-K" fitness landscapes, which have found applications in biology[19] and economics.[20][21] In related work, Kauffman and colleagues have examined subcritical, critical, and supracritical behavior in economic systems.[22]

Kauffman's recent work translates his biological findings to the mind body problem and issues in neuroscience, proposing attributes of a new "poised realm" that hovers indefinitely between quantum coherence and classicality. Kauffman published on this topic in Answering Descartes: Beyond Turing.[23] With colleagues Giuseppe Longo and Maël Montévil, Stuart Kauffman wrote (January 2012) "No entailing laws, but enablement in the evolution of the biosphere",[24] which aims to show that evolution is not law entailed, as is physics, and that, without selection, evolution enables its own future possibilities.

Kauffman's recent work is posted on Physics ArXiv, including "Beyond the Stalemate: Mind/Body, Quantum Mechanics, Free Will, Possible Panpsychism, Possible Solution to the Quantum Enigma" (October 2014)[25] and "Quantum Criticality at the Origin of Life" (February 2015).[18]

He has published over 300 articles and 4 books: The Origins of Order (1993), At Home in the Universe (1995), Investigations (2000), and Reinventing the Sacred (2008). A fifth book, Humanity in a Creative Universe is under contract for 2015, with Oxford University Press.[citation needed]

Publications[edit]

Selected articles
Selected books
  • Kauffman, Stuart (1993). The Origins of Order: Self Organization and Selection in Evolution. Oxford University Press. ISBN 0-19-507951-5. 
  • Kauffman, Stuart (1995). At Home in the Universe: The Search for Laws of Self-Organization and Complexity. Oxford University Press. ISBN 0195111303. 
  • Kauffman, Stuart (2000). Investigations. Oxford University Press. ISBN 0199728941. 
  • Kauffman, Stuart (2008). Reinventing the Sacred: A New View of Science, Reason, and Religion. Basic Books. ISBN 0-465-00300-1. 
Selected presentations

Notes[edit]

  1. ^ Kauffman & McCulloch 1967.
  2. ^ Kauffman 1969.
  3. ^ a b Huang & Kauffman 2009.
  4. ^ Kauffman 1971a.
  5. ^ Huang et al. 2009.
  6. ^ Kauffman 1971b.
  7. ^ Kauffman 2011.
  8. ^ Dadon, Wagner & Ashkenasy 2008.
  9. ^ Dadon et al. 2012.
  10. ^ Nykter et al. 2008.
  11. ^ Chialvo 2013.
  12. ^ US 5,723,323  "Method of identifying a stochastically-generated peptide, polypeptide, or protein having ligand binding property and compositions thereof."
  13. ^ "Stuart Kauffman, complex systems pioneer, to join UVM faculty". Vermontbiz.com (Vermont Business Magazine). September 30, 2009. Retrieved 2015-04-28. 
  14. ^ "Stuart Kauffman". NPR.org. Retrieved 2015-04-28. 
  15. ^ "Stuart A. Kauffman". Edge.org. Edge Foundation. Retrieved 2015-04-28. 
  16. ^ Kauffman et al. 2014b.
  17. ^ (US 20120071333A1 (12)PatentApplicationPublication (10)Pub.No.:US2012/0071333A1 (19)United States).
  18. ^ a b Vattay et al. 2015.
  19. ^ Kauffman & Johnsen 1991.
  20. ^ Rivkin & Siggelkow 2002.
  21. ^ Felin et al. 2014.
  22. ^ Hanel, Kauffman & Thurner 2007.
  23. ^ Kauffman 2014a.
  24. ^ Longo, Montévil & Kauffman 2012.
  25. ^ Kauffman 2014.

References[edit]

  • Chialvo, D. R. (2013). "Critical Brain Dynamics at Large Scale". In Plenz D.; Niebur, E.; Schuster H. G. Criticality in Neural Systems 1. Wiley. ISBN 978-3-527-41104-7. 
  • Dadon, Z.; Wagner, N.; Ashkenasy, G. (2008). "The Road to Non-Enzymatic Molecular Networks". Angew. Chem. Int. 47: 6128. 
  • Dadon, Z.; Wagner, N.; Cohen-Luria, R.; Ashkenasy, G. (2012). "Reaction Networks. Wagner and Askkenazy's (2008) results demonstrate that molecular replication need not be based on DNA or RNA template replication, still the dominate view for the origin of life". In Gale, P. A.; Steed J. W. Supramolecular Chemistry: From Molecules to Nanomaterials. John Wiley and Sons, Ltd. ISBN 978-0-470-74640-0. 
  • Rivkin, J. W.; Siggelkow, N. (May–June 2002). "Organizational Sticking Points on NK Landscapes". Complexity 7 (5): 31–43. Retrieved 2015-04-28. 

Further reading[edit]

Interviews

External links[edit]

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