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Sulbutiamine Review - A Few Benefits and Important Side Effects
Sulbutiamine Review - A Few Benefits and Important Side Effects
Published: 2016/08/30
Channel: Mansal Denton
**Official Sulbutiamine Review** -- Sleepy w/ High Dose - Motivated w/ Right Dose
**Official Sulbutiamine Review** -- Sleepy w/ High Dose - Motivated w/ Right Dose
Published: 2017/03/17
Channel: Cortex Labs Nootropics Channel
Sulbutiamine dosage, I love this nootropic
Sulbutiamine dosage, I love this nootropic
Published: 2009/04/07
Channel: goyaface
Sulbutiamine Review -  Insane Mental and Physical Energy
Sulbutiamine Review - Insane Mental and Physical Energy
Published: 2016/09/26
Channel: gonootropics
Sulbutiamine -- What is it and What does it do?!
Sulbutiamine -- What is it and What does it do?!
Published: 2017/08/04
Channel: PricePlow
"Smart Drug" Review | Sulbutiamine
"Smart Drug" Review | Sulbutiamine
Published: 2013/08/29
Channel: ThePromisedWLAN
Why is Sulbutiamine WORKING so well?
Why is Sulbutiamine WORKING so well?
Published: 2018/02/06
Channel: Cortex Labs Nootropics Channel
Top 5 Nootropics the Elite 1% Are Taking | This Week in Biohacking EP01
Top 5 Nootropics the Elite 1% Are Taking | This Week in Biohacking EP01
Published: 2015/12/05
Channel: Steve Cronin
Sulbutiamine Review: One of my least favorite white powders
Sulbutiamine Review: One of my least favorite white powders
Published: 2016/03/18
Channel: Limitless Mindset
Nootropics For A Night On The Town
Nootropics For A Night On The Town
Published: 2016/09/29
Channel: gonootropics
Episode 8 - Dr  Stephen Born talks Sulbutiamine
Episode 8 - Dr Stephen Born talks Sulbutiamine
Published: 2014/03/01
Channel: Smart Drug Smarts
Sulbutiamine - sulbutiamine dosage
Sulbutiamine - sulbutiamine dosage
Published: 2016/07/05
Channel: MXEL Edge - Brain Enhancement Supplements
Sulbutiamine Benefits and Dosage Review from Absorb Health Supplements
Sulbutiamine Benefits and Dosage Review from Absorb Health Supplements
Published: 2014/09/25
Channel: Absorb Health
Sulbutiamine: The Samurai Sword of Nootropics that Calibrates the RAS and Vanquishes Social Anxiety
Sulbutiamine: The Samurai Sword of Nootropics that Calibrates the RAS and Vanquishes Social Anxiety
Published: 2014/05/18
Channel: Limitless Mindset
Use of Sulbutiamine for Chronic Fatigue
Use of Sulbutiamine for Chronic Fatigue
Published: 2016/06/09
Channel: ifsmed
Sulbutiamine Experience Report
Sulbutiamine Experience Report
Published: 2015/05/04
Channel: Akroma Jones
Study Stimulants: Modafinil and Sulbutiamine Experience
Study Stimulants: Modafinil and Sulbutiamine Experience
Published: 2015/05/30
Channel: Billy Noots
Sulbutiamine Review
Sulbutiamine Review
Published: 2017/06/30
Channel: brotropics
Sulbutiamine [30g NutraPlanet]
Sulbutiamine [30g NutraPlanet]
Published: 2012/07/07
Channel: Nootropics101
My experience with Sulbutiamine nootropic -- for cyclists
My experience with Sulbutiamine nootropic -- for cyclists
Published: 2009/04/07
Channel: goyaface
Sulbutiamine - "Neuro Flow" Review @EpicBeasts
Sulbutiamine - "Neuro Flow" Review @EpicBeasts
Published: 2015/09/07
Channel: Epic Beasts
Bremelanotide (pt141) Experience Report
Bremelanotide (pt141) Experience Report
Published: 2015/06/04
Channel: Akroma Jones
Best Nootropic - Noopept, Aniracetam, Sulbutiamine...
Best Nootropic - Noopept, Aniracetam, Sulbutiamine...
Published: 2013/10/17
Channel: Luciminal Nootropics
Booster votre productivité Arcalion (sulbutiamine, nootropique)
Booster votre productivité Arcalion (sulbutiamine, nootropique)
Published: 2017/01/14
Channel: NAYL DEWITTE : NOOTROPIQUE & BIOHACKING
(Sulbuiamine Review) - Synthetic Vitamin Nootropic
(Sulbuiamine Review) - Synthetic Vitamin Nootropic
Published: 2014/01/02
Channel: Jennifer Pauling
Best Nootropics 2017
Best Nootropics 2017
Published: 2017/05/26
Channel: NootropicsExpert
Best Nootropics Stack For Studying, Focus, and Energy
Best Nootropics Stack For Studying, Focus, and Energy
Published: 2016/10/27
Channel: gonootropics
Luis Sosa: Sensación de debilidad puede disminuir con la vitamina sulbutiamina
Luis Sosa: Sensación de debilidad puede disminuir con la vitamina sulbutiamina
Published: 2014/10/11
Channel: El Diario de Caracas
Liftmode Phenibut Review
Liftmode Phenibut Review
Published: 2016/10/16
Channel: MokaShift
Best Nootropics for 2018
Best Nootropics for 2018
Published: 2018/01/26
Channel: NootropicsExpert
Increase Brain Performance with Mitogen by Axon Labs
Increase Brain Performance with Mitogen by Axon Labs
Published: 2016/03/12
Channel: Steve Cronin
5 PRODUITS PSYCHO-STIMULANT POUR REUSSIR VOS EXAMS
5 PRODUITS PSYCHO-STIMULANT POUR REUSSIR VOS EXAMS
Published: 2016/03/20
Channel: Doc Falter
3 Powerhouse Nootropics Guaranteed To Work
3 Powerhouse Nootropics Guaranteed To Work
Published: 2017/01/22
Channel: gonootropics
GABA as a Nootropic: Biohacking the Metaphorical Little Devil on Your Shoulder
GABA as a Nootropic: Biohacking the Metaphorical Little Devil on Your Shoulder
Published: 2014/05/26
Channel: Limitless Mindset
Top 5 Best Vitamin B1 Reviews 2017
Top 5 Best Vitamin B1 Reviews 2017
Published: 2017/09/07
Channel: Susan C
How to Pronounce Sulbutiamine
How to Pronounce Sulbutiamine
Published: 2015/06/02
Channel: Pronunciation Guide
The Social Anxiety Protocol: The Methodology
The Social Anxiety Protocol: The Methodology
Published: 2016/02/29
Channel: Limitless Mindset
Powerful Nootropic Stack Supplements (review)
Powerful Nootropic Stack Supplements (review)
Published: 2016/11/17
Channel: Brain Supplements
Subliminal: Nootropics MIND POWER RELOAD
Subliminal: Nootropics MIND POWER RELOAD
Published: 2017/01/08
Channel: Foxy Production
Phenylpiracetam
Phenylpiracetam's AMPERAGE and STIMULANT effects
Published: 2017/11/16
Channel: Cortex Labs Nootropics Channel
Brain Booster Power Pack Benefits and Dosage Review from Absorb Health Supplements
Brain Booster Power Pack Benefits and Dosage Review from Absorb Health Supplements
Published: 2015/06/17
Channel: Absorb Health
nootropics with euphoria
nootropics with euphoria
Published: 2016/08/07
Channel: vidranker
Les produits psychostimulants
Les produits psychostimulants
Published: 2016/01/22
Channel: Grégoire CLAUS
Les conseils Supersmart - La pyramide de la nutrition
Les conseils Supersmart - La pyramide de la nutrition
Published: 2016/06/29
Channel: Super Smart
Top 10 Best Vitamin B1 (Thiamine) Supplements
Top 10 Best Vitamin B1 (Thiamine) Supplements
Published: 2017/02/08
Channel: Mike Jason
Nootropic Review: Sunifiram
Nootropic Review: Sunifiram
Published: 2013/06/26
Channel: Billy Noots
Noopept et mémoire : Miracle ou Arnaque ?
Noopept et mémoire : Miracle ou Arnaque ?
Published: 2015/03/04
Channel: Nootropiques.org
The Ultimate Motivation Nootropic Stack (Phenyl/Tyro/ALCAR)
The Ultimate Motivation Nootropic Stack (Phenyl/Tyro/ALCAR)
Published: 2017/07/28
Channel: Cortex Labs Nootropics Channel
Day 2 Morning
Day 2 Morning
Published: 2016/09/03
Channel: William Ashley
ASTENIA - CANSANCIO FATIGA
ASTENIA - CANSANCIO FATIGA
Published: 2015/09/14
Channel: Hernando Coral Rosero
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WIKIPEDIA ARTICLE

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Sulbutiamine
Skeletal formula of sulbutiamine
Space-filling model of the sulbutiamine molecule
Clinical data
Synonyms Arcalion
AHFS/Drugs.com International Drug Names
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Biological half-life 5 hours
Excretion Renal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ECHA InfoCard 100.019.944
Chemical and physical data
Formula C32H46N8O6S2
Molar mass 702.89 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Sulbutiamine (brand name: Arcalion) is a synthetic derivative of thiamine (vitamin B1). It is used in France to treat symptoms of weakness or fatigue, but there is not good data to support this. It is sold as a dietary supplement. Sulbutiamine was discovered in Japan as part of an effort to develop more useful thiamine derivatives.

Medical use[edit]

Sulbutiamine is used to treat asthenia (symptoms of fatigue or weakness) in France.[1] It is not clear if it is effective.[2]

Adverse effects[edit]

Adverse effects in clinical trials have included diarrhea, bladder infections, bronchitis, arthritic pain, back pain, asthma, abdominal pain, insomnia, constipation, gastroenteritis, diffuse pain, sinusitis, headache, kidney pain, vertigo, and sore throat.[3]

History[edit]

Thiamine

Efforts to develop thiamine derivatives with better bioavaiability than thiamine were conducted in the 1950s, mainly in Japan. These efforts led to the discovery of allicin (diallyl thiosulfinate) in garlic, which became a model for medicinal chemistry efforts to create other thiamine disulfides. The results included sulbutiamine, fursultiamine (thiamine tetrahydrofurfuryl disulfide) and benfothiamine. These compounds are hydrophobic, easily pass from the intestines to the bloodstream, and are reduce to thiamine by cysteine or glutathione.[4]:302[5]

It was first marketed in France by Servier in 1973 under the brand name Arcalion. The drug registration went through a validation procedure in France in the 1980s, which found that the use for treatment of fatigue was not supported by data.[2]

Society and culture[edit]

The French government does not pay for prescriptions of sulbutiamine.[1][2]

Sulbutiamine is sold as a dietary supplement; it appears that endurance athletes may use it to try to enhance their performance.[6]

It is also used as a nootropic dietary supplement; in 2014 the UK Medicines and Healthcare Regulatory Agency seized a shipment of nooptropics worth around £200,000 that included sulbutiamine.[7]

Research[edit]

Because thiamine deficiency causes problems with memory and other cognitive functions, thiamine and analogs like sulbutiamine have been studied in clinical trials in the 1980s and 1990s for age-associated cognitive decline.[8]

Sulbutiamine has been explored in clinical trials as a potential treatment for chronic fatigue syndrome.[3]

The pharmacology of subutiamine has been studied in various mice and rats; as of 2014 it appeared that subutiamine might be more effective than in raising thiamine phosphate levels in the brain than benfotiamine and fursultiamine, but this was not certain.[4]:303

See also[edit]

References[edit]

  1. ^ a b "Fiche info - Araclion 200 mg" (in French). Base de données publique des médicaments: ANSM of HAS et UNCAM. Retrieved 28 January 2018. 
  2. ^ a b c Rane, Wishvas (1997). "High Cost, Low Efficiency Medicines". Economic and Political Weekly. 32 (51): 3251–3251. JSTOR 4406199. 
  3. ^ a b Alraek, T; Lee, MS; Choi, TY; Cao, H; Liu, J (7 October 2011). "Complementary and alternative medicine for patients with chronic fatigue syndrome: a systematic review". BMC complementary and alternative medicine. 11: 87. doi:10.1186/1472-6882-11-87. PMC 3201900Freely accessible. PMID 21982120. 
  4. ^ a b Bettendorff, Lucien (2014). "Chapter 7 - Thiamine". In Zempleni, Janos; Suttie, John W.; Gregory, Jesse F.; Stover, Patrick J. Handbook of vitamins (Fifth edition ed.). Hoboken: CRC Press. pp. 267–324. ISBN 9781466515574. 
  5. ^ Volvert ML, Seyen S, Piette M, Evrard B, Gangolf M, Plumier JC, Bettendorff L (2008). "Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives". BMC Pharmaco. 8: 10. doi:10.1186/1471-2210-8-10. PMC 2435522Freely accessible. PMID 18549472. 
  6. ^ Kazlauskas, R (2010). "Advances in sports drug testing: an overview". Drug testing and analysis. 2 (11-12): 523–5. doi:10.1002/dta.251. PMID 21204284.  open access publication – free to read
  7. ^ "Record seizure of experimental "smart drugs" in UK". Reactions Weekly. 1526 (1): 4–4. 8 November 2014. doi:10.1007/s40278-014-4651-7. 
  8. ^ Riedel, WJ; Jolles, J (April 1996). "Cognition enhancers in age-related cognitive decline". Drugs & aging. 8 (4): 245–74. PMID 8920174. 

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