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Sunifiram: Mental clarity + sublingual + oral doses
Sunifiram: Mental clarity + sublingual + oral doses
Published: 2017/09/04
Channel: Cortex Labs Nootropics Channel
Sunifiram as a Nootropic: a Value Leading Racetam that Delivers Clarity
Sunifiram as a Nootropic: a Value Leading Racetam that Delivers Clarity
Published: 2014/11/03
Channel: Limitless Mindset
(Sunifiram Review) - Ampakine Nootropic
(Sunifiram Review) - Ampakine Nootropic
Published: 2014/01/02
Channel: Jennifer Pauling
Nootropic Review: Sunifiram
Nootropic Review: Sunifiram
Published: 2013/06/26
Channel: Billy Noots
Ep 32: Sunifiram: doses, mechanisms, and experiences
Ep 32: Sunifiram: doses, mechanisms, and experiences
Published: 2017/09/05
Channel: Cortex Labs Nootropics Channel
LVUP#28: Sunifiram, Statements/Kommentare [Nootropika, Talk]
LVUP#28: Sunifiram, Statements/Kommentare [Nootropika, Talk]
Published: 2017/06/04
Channel: Zets Base
Nootropics Review. Phenylpiracetam, Bromantane and Sunifiram
Nootropics Review. Phenylpiracetam, Bromantane and Sunifiram
Published: 2017/05/14
Channel: Ushutup Productions
Sunifiram Dosage Recommendations and Longecity Reviews
Sunifiram Dosage Recommendations and Longecity Reviews
Published: 2017/08/29
Channel: Nootropics University
My INTENSE Unifiram Nootropic Experience (+ 4 hours later)
My INTENSE Unifiram Nootropic Experience (+ 4 hours later)
Published: 2017/09/13
Channel: Cortex Labs Nootropics Channel
SFG#10: Sunifiram + Noopept Nasal + Phenylpiracetam STACK
SFG#10: Sunifiram + Noopept Nasal + Phenylpiracetam STACK
Published: 2017/10/31
Channel: Cortex Labs Nootropics Channel
A Pill That Makes People Learn New Skills as Fast as Children
A Pill That Makes People Learn New Skills as Fast as Children
Published: 2014/04/02
Channel: GeoBeats News
Sunifiram Review Logs Online Sunifiram Capsules
Sunifiram Review Logs Online Sunifiram Capsules
Published: 2017/08/25
Channel: Nootropics University
My take on DMAE/Centrophenoxine (plus doses + effects)
My take on DMAE/Centrophenoxine (plus doses + effects)
Published: 2017/10/26
Channel: Cortex Labs Nootropics Channel
What are Ampakine Nootropics? Sunifiram vs Unifiram vs Noopept
What are Ampakine Nootropics? Sunifiram vs Unifiram vs Noopept
Published: 2017/11/21
Channel: Nootropics University
Nootropics on the Unsuspecting
Nootropics on the Unsuspecting
Published: 2013/04/19
Channel: anthonynlee
Sunifiram - Mandelin Reagent - Normal Test Kit - Bunk Police
Sunifiram - Mandelin Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/08
Channel: Bunk Police
Phenylpiracetam by LiftMode | 90 Days Later (Review)
Phenylpiracetam by LiftMode | 90 Days Later (Review)
Published: 2014/02/23
Channel: ThePromisedWLAN
Methylene Blue Review: The Nootropic drops that make me look like I cannibalized a smurf!
Methylene Blue Review: The Nootropic drops that make me look like I cannibalized a smurf!
Published: 2017/01/16
Channel: Limitless Mindset
$4100 in 50 Minutes: The Neurotransmitter Cocktail I Mix to Seduce and Profit
$4100 in 50 Minutes: The Neurotransmitter Cocktail I Mix to Seduce and Profit
Published: 2014/09/15
Channel: Limitless Mindset
Increase your Concentration & Memory with Oxiracetam by Star Nootropics
Increase your Concentration & Memory with Oxiracetam by Star Nootropics
Published: 2015/06/04
Channel: Steve Cronin
Ампакины
Ампакины
Published: 2016/07/01
Channel: mednauka.net
Sunifiram - Marquis Reagent - Normal Test Kit - Bunk Police
Sunifiram - Marquis Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/08
Channel: Bunk Police
"Smart Drug" Review | Sulbutiamine
"Smart Drug" Review | Sulbutiamine
Published: 2013/08/29
Channel: ThePromisedWLAN
(Phenylpiracetam review) - Racetam Nootropic Benefits
(Phenylpiracetam review) - Racetam Nootropic Benefits
Published: 2014/01/02
Channel: Jennifer Pauling
Episode 83 - Aniracetam – First of the Ampakines
Episode 83 - Aniracetam – First of the Ampakines
Published: 2015/07/08
Channel: Smart Drug Smarts
Unifiram Powder Dosage Recommendations
Unifiram Powder Dosage Recommendations
Published: 2017/10/17
Channel: Nootropics University
Nootropy (smart drugs, brain boosters). Ziołowe i syntetyczne
Nootropy (smart drugs, brain boosters). Ziołowe i syntetyczne
Published: 2017/06/06
Channel: Pod Mikroskopem
Nootropic Review: Post-exam overview
Nootropic Review: Post-exam overview
Published: 2013/06/22
Channel: Billy Noots
Unifiram · Nootropics
Unifiram · Nootropics
Published: 2015/01/06
Channel: Nootropics TV
Sunifiram - Liebermann Reagent - Normal Test Kit - Bunk Police
Sunifiram - Liebermann Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/08
Channel: Bunk Police
Sunifiram - Robadope Reagent - Normal Test Kit - Bunk Police
Sunifiram - Robadope Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/04
Channel: Bunk Police
Sunifiram - Hoffman Reagent - Normal Test Kit - Bunk Police
Sunifiram - Hoffman Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/04
Channel: Bunk Police
Sunifiram - Ehrlich Reagent - Normal Test Kit - Bunk Police
Sunifiram - Ehrlich Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/04
Channel: Bunk Police
Qualia Nootropic Review: Day 5
Qualia Nootropic Review: Day 5
Published: 2017/09/24
Channel: The Neuro Lifestyle
Sunifiram - Froehde Reagent - Normal Test Kit - Bunk Police
Sunifiram - Froehde Reagent - Normal Test Kit - Bunk Police
Published: 2015/11/11
Channel: Acinad Romanoff
Sunifiram - Simons Reagent - Normal Test Kit - Bunk Police
Sunifiram - Simons Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/03
Channel: Bunk Police
Where to buy Sarms
Where to buy Sarms
Published: 2017/03/29
Channel: Cindy Hu
(Noopept Review) - Benefits & Side Effects
(Noopept Review) - Benefits & Side Effects
Published: 2013/11/29
Channel: Jennifer Pauling
Sarm powder  (whatsapp008613720208757)
Sarm powder (whatsapp008613720208757)
Published: 2017/02/16
Channel: chen coco
Sunifiram - Mecke Reagent - Normal Test Kit - Bunk Police
Sunifiram - Mecke Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/03
Channel: Bunk Police
Buy Nootropic-Piracetol
Buy Nootropic-Piracetol
Published: 2017/11/24
Channel: The Memory Improvement Store
Selbstexperiment: Nootropics - Machen diese Pillen schlau? | Galileo | ProSieben
Selbstexperiment: Nootropics - Machen diese Pillen schlau? | Galileo | ProSieben
Published: 2017/07/11
Channel: Galileo
Noopept as a Nootropic: an Economical Social Smart Drug with Subtle Psychostimulatory Effects
Noopept as a Nootropic: an Economical Social Smart Drug with Subtle Psychostimulatory Effects
Published: 2014/06/02
Channel: Limitless Mindset
Episode 46 - Improving on Piracetam with Noopept
Episode 46 - Improving on Piracetam with Noopept
Published: 2014/12/20
Channel: Smart Drug Smarts
Official PRL-8-53 Review/Definitive Breakdown
Official PRL-8-53 Review/Definitive Breakdown
Published: 2017/05/24
Channel: Cortex Labs Nootropics Channel
Nootropic Review: Noopept
Nootropic Review: Noopept
Published: 2013/04/26
Channel: Billy Noots
LevelUp#1(DE): Nootropika Überblick
LevelUp#1(DE): Nootropika Überblick
Published: 2016/06/12
Channel: Zets Base
АМПАкины: Реновация Ноотропов
АМПАкины: Реновация Ноотропов
Published: 2015/07/08
Channel: CleverMindRu
LVUP#26: Noopept-Review - Werden die Erwartungen erfüllt? [ACHTUNG, 10mg!! NICHT 30mg!]
LVUP#26: Noopept-Review - Werden die Erwartungen erfüllt? [ACHTUNG, 10mg!! NICHT 30mg!]
Published: 2017/04/20
Channel: Zets Base
My #1 Neuro-protective NOOTROPIC (hint - not a racetam)
My #1 Neuro-protective NOOTROPIC (hint - not a racetam)
Published: 2017/09/19
Channel: Cortex Labs Nootropics Channel
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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Sunifiram
Sunifiram.svg
Clinical data
Synonyms DM-235
Legal status
Legal status
  • US: Not FDA approved; unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C14H18N2O2
Molar mass 246.304 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Sunifiram (developmental code name DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam.[1] Sunifiram is a molecular simplification of unifiram (DM-232).[2] Another analogue is sapunifiram (MN-19).[3] As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world.[1]

Pharmacology[edit]

The mechanism of action of sunifiram is unknown.[4] Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites.[4][3] They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors at concentrations of up to 1 μM.[4][3] In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators.[4] However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects.[3]

Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (Ki = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversing scopolamine-induced memory deficits in mice.[3] However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram.[4]

References[edit]

  1. ^ a b Gualtieri F (2016). "Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings". Journal of Enzyme Inhibition and Medicinal Chemistry. 31 (2): 187–94. doi:10.3109/14756366.2015.1021252. PMID 25831025. 
  2. ^ Manetti, D.; Ghelardini, C.; Bartolini, A.; Dei, S.; Galeotti, N.; Gualtieri, F.; Romanelli, M. N.; Teodori, E. (2000). "Molecular simplification of 1,4-diazabicyclo4.3.0nonan-9-ones gives piperazine derivatives that maintain high nootropic activity". Journal of Medicinal Chemistry. 43 (23): 4499–4507. doi:10.1021/jm000972h. PMID 11087574. 
  3. ^ a b c d e Romanelli MN, Galeotti N, Ghelardini C, Manetti D, Martini E, Gualtieri F (2006). "Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers". CNS Drug Rev. 12 (1): 39–52. doi:10.1111/j.1527-3458.2006.00039.x. PMID 16834757. 
  4. ^ a b c d e Gualtieri F (2016). "Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings". J Enzyme Inhib Med Chem. 31 (2): 187–94. doi:10.3109/14756366.2015.1021252. PMID 25831025. 

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