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Sunifiram as a Nootropic: a Value Leading Racetam that Delivers Clarity
Sunifiram as a Nootropic: a Value Leading Racetam that Delivers Clarity
Published: 2014/11/03
Channel: Limitless Mindset
(Sunifiram Review) - Ampakine Nootropic
(Sunifiram Review) - Ampakine Nootropic
Published: 2014/01/02
Channel: Jennifer Pauling
Sunifiram: Mental clarity + sublingual + oral doses
Sunifiram: Mental clarity + sublingual + oral doses
Published: 2017/09/04
Channel: Cortex Labs Nootropics Channel
Nootropic Review: Sunifiram
Nootropic Review: Sunifiram
Published: 2013/06/26
Channel: Billy Noots
Nootropics Review. Phenylpiracetam, Bromantane and Sunifiram
Nootropics Review. Phenylpiracetam, Bromantane and Sunifiram
Published: 2017/05/14
Channel: Ushutup Productions
LVUP#28: Sunifiram, Statements/Kommentare [Nootropika, Talk]
LVUP#28: Sunifiram, Statements/Kommentare [Nootropika, Talk]
Published: 2017/06/04
Channel: Zets Base
Ep 32: Sunifiram: doses, mechanisms, and experiences
Ep 32: Sunifiram: doses, mechanisms, and experiences
Published: 2017/09/05
Channel: Cortex Labs Nootropics Channel
Sunifiram Dosage Recommendations and Longecity Reviews
Sunifiram Dosage Recommendations and Longecity Reviews
Published: 2017/08/29
Channel: Nootropics University
Sunifiram Review Logs Online Sunifiram Capsules
Sunifiram Review Logs Online Sunifiram Capsules
Published: 2017/08/25
Channel: Nootropics University
$4100 in 50 Minutes: The Neurotransmitter Cocktail I Mix to Seduce and Profit
$4100 in 50 Minutes: The Neurotransmitter Cocktail I Mix to Seduce and Profit
Published: 2014/09/15
Channel: Limitless Mindset
Nootropics on the Unsuspecting
Nootropics on the Unsuspecting
Published: 2013/04/19
Channel: anthonynlee
Episode 83 - Aniracetam – First of the Ampakines
Episode 83 - Aniracetam – First of the Ampakines
Published: 2015/07/08
Channel: Smart Drug Smarts
Siberian Ginseng the Military Grade Nootropic for Combating Fatigue
Siberian Ginseng the Military Grade Nootropic for Combating Fatigue
Published: 2017/04/10
Channel: Limitless Mindset
"Smart Drug" Review | Sulbutiamine
"Smart Drug" Review | Sulbutiamine
Published: 2013/08/29
Channel: ThePromisedWLAN
Optimizing Cognition with ALA + Red Wine (nootropic benefits)
Optimizing Cognition with ALA + Red Wine (nootropic benefits)
Published: 2017/09/22
Channel: Cortex Labs Nootropics Channel
Sunifiram - Mandelin Reagent - Normal Test Kit - Bunk Police
Sunifiram - Mandelin Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/08
Channel: Bunk Police
Qualia Nootropic Review: Day 5
Qualia Nootropic Review: Day 5
Published: 2017/09/24
Channel: The Neuro Lifestyle
Methylene Blue Review: The Nootropic drops that make me look like I cannibalized a smurf!
Methylene Blue Review: The Nootropic drops that make me look like I cannibalized a smurf!
Published: 2017/01/16
Channel: Limitless Mindset
Sunifiram - Simons Reagent - Normal Test Kit - Bunk Police
Sunifiram - Simons Reagent - Normal Test Kit - Bunk Police
Published: 2015/11/11
Channel: Acinad Romanoff
Sunifiram - Hoffman Reagent - Normal Test Kit - Bunk Police
Sunifiram - Hoffman Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/04
Channel: Bunk Police
Sunifiram - Marquis Reagent - Normal Test Kit - Bunk Police
Sunifiram - Marquis Reagent - Normal Test Kit - Bunk Police
Published: 2015/11/11
Channel: Acinad Romanoff
Nootropic Review: Post-exam overview
Nootropic Review: Post-exam overview
Published: 2013/06/22
Channel: Billy Noots
Sunifiram - Mecke Reagent - Normal Test Kit - Bunk Police
Sunifiram - Mecke Reagent - Normal Test Kit - Bunk Police
Published: 2015/11/11
Channel: Acinad Romanoff
(Phenylpiracetam review) - Racetam Nootropic Benefits
(Phenylpiracetam review) - Racetam Nootropic Benefits
Published: 2014/01/02
Channel: Jennifer Pauling
Phenylpiracetam by LiftMode | 90 Days Later (Review)
Phenylpiracetam by LiftMode | 90 Days Later (Review)
Published: 2014/02/23
Channel: ThePromisedWLAN
Sarm powder  (whatsapp008613720208757)
Sarm powder (whatsapp008613720208757)
Published: 2017/02/16
Channel: chen coco
Increase your Concentration & Memory with Oxiracetam by Star Nootropics
Increase your Concentration & Memory with Oxiracetam by Star Nootropics
Published: 2015/06/04
Channel: Steve Cronin
Sunifiram - Froehde Reagent - Normal Test Kit - Bunk Police
Sunifiram - Froehde Reagent - Normal Test Kit - Bunk Police
Published: 2015/11/11
Channel: Acinad Romanoff
Sunifiram - Ehrlich Reagent - Normal Test Kit - Bunk Police
Sunifiram - Ehrlich Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/04
Channel: Bunk Police
A Pill That Makes People Learn New Skills as Fast as Children
A Pill That Makes People Learn New Skills as Fast as Children
Published: 2014/04/02
Channel: GeoBeats News
Sunifiram - Liebermann Reagent - Normal Test Kit - Bunk Police
Sunifiram - Liebermann Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/08
Channel: Bunk Police
Unifiram · Nootropics
Unifiram · Nootropics
Published: 2015/01/06
Channel: Nootropics TV
Official PRL-8-53 Review/Definitive Breakdown
Official PRL-8-53 Review/Definitive Breakdown
Published: 2017/05/24
Channel: Cortex Labs Nootropics Channel
Piracetam: ALL You Need to Know
Piracetam: ALL You Need to Know
Published: 2016/11/05
Channel: Cortex Labs Nootropics Channel
Sunifiram - Robadope Reagent - Normal Test Kit - Bunk Police
Sunifiram - Robadope Reagent - Normal Test Kit - Bunk Police
Published: 2015/12/04
Channel: Bunk Police
(Noopept Review) - Benefits & Side Effects
(Noopept Review) - Benefits & Side Effects
Published: 2013/11/29
Channel: Jennifer Pauling
Alternating dopaminergic nootropics and cholinergic nootropics
Alternating dopaminergic nootropics and cholinergic nootropics
Published: 2017/08/23
Channel: Cortex Labs Nootropics Channel
LevelUp#1(DE): Nootropika Überblick
LevelUp#1(DE): Nootropika Überblick
Published: 2016/06/12
Channel: Zets Base
Nootropy (smart drugs, brain boosters). Ziołowe i syntetyczne
Nootropy (smart drugs, brain boosters). Ziołowe i syntetyczne
Published: 2017/06/06
Channel: Pod Mikroskopem
My INTENSE Unifiram Nootropic Experience (+ 4 hours later)
My INTENSE Unifiram Nootropic Experience (+ 4 hours later)
Published: 2017/09/13
Channel: Cortex Labs Nootropics Channel
Selbstexperiment: Nootropics - Machen diese Pillen schlau? | Galileo | ProSieben
Selbstexperiment: Nootropics - Machen diese Pillen schlau? | Galileo | ProSieben
Published: 2017/07/11
Channel: Galileo
związek lepszy
związek lepszy
Published: 2011/07/08
Channel: UMAL2011
Ампакины
Ампакины
Published: 2016/07/01
Channel: mednauka.net
Unifiram Powder Dosage Recommendations
Unifiram Powder Dosage Recommendations
Published: 2017/10/17
Channel: Nootropics University
Where to buy Sarms
Where to buy Sarms
Published: 2017/03/29
Channel: Cindy Hu
Gehirndoping & Vergessen per Pille - Wie Gehirnforschung unser Leben verändert | Let
Gehirndoping & Vergessen per Pille - Wie Gehirnforschung unser Leben verändert | Let's Denk #2
Published: 2012/05/06
Channel: LetsDenk
Noopept as a Nootropic: an Economical Social Smart Drug with Subtle Psychostimulatory Effects
Noopept as a Nootropic: an Economical Social Smart Drug with Subtle Psychostimulatory Effects
Published: 2014/06/02
Channel: Limitless Mindset
Nootropics BANNED in the UK!? | This Week in Biohacking EP06
Nootropics BANNED in the UK!? | This Week in Biohacking EP06
Published: 2016/02/15
Channel: Steve Cronin
Non nootropics users SPEED OF PROCESSING is slow
Non nootropics users SPEED OF PROCESSING is slow
Published: 2017/09/06
Channel: Cortex Labs Nootropics Channel
Nootropics POWER USERS VS Minimalists (Why 1 VS other)
Nootropics POWER USERS VS Minimalists (Why 1 VS other)
Published: 2017/09/03
Channel: Cortex Labs Nootropics Channel
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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Sunifiram
Sunifiram.svg
Clinical data
Synonyms DM-235
Legal status
Legal status
  • US: Not FDA approved; unscheduled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C14H18N2O2
Molar mass 246.304 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Sunifiram (developmental code name DM-235) is an experimental drug which has antiamnesic effects in animal studies and with significantly higher potency than piracetam.[1] Sunifiram is a molecular simplification of unifiram (DM-232).[2] Another analogue is sapunifiram (MN-19).[3] As of 2016, sunifiram had not been subjected to toxicology testing, nor to any human clinical trials, and is not approved for use anywhere in the world.[1]

Pharmacology[edit]

The mechanism of action of sunifiram is unknown.[4] Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites.[4][3] They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors at concentrations of up to 1 μM.[4][3] In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators.[4] However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects.[3]

Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (Ki = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversing scopolamine-induced memory deficits in mice.[3] However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram.[4]

References[edit]

  1. ^ a b Gualtieri F (2016). "Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings". Journal of Enzyme Inhibition and Medicinal Chemistry. 31 (2): 187–94. PMID 25831025. doi:10.3109/14756366.2015.1021252. 
  2. ^ Manetti, D.; Ghelardini, C.; Bartolini, A.; Dei, S.; Galeotti, N.; Gualtieri, F.; Romanelli, M. N.; Teodori, E. (2000). "Molecular simplification of 1,4-diazabicyclo4.3.0nonan-9-ones gives piperazine derivatives that maintain high nootropic activity". Journal of Medicinal Chemistry. 43 (23): 4499–4507. PMID 11087574. doi:10.1021/jm000972h. 
  3. ^ a b c d e Romanelli MN, Galeotti N, Ghelardini C, Manetti D, Martini E, Gualtieri F (2006). "Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers". CNS Drug Rev. 12 (1): 39–52. PMID 16834757. doi:10.1111/j.1527-3458.2006.00039.x. 
  4. ^ a b c d e Gualtieri F (2016). "Unifi nootropics from the lab to the web: a story of academic (and industrial) shortcomings". J Enzyme Inhib Med Chem. 31 (2): 187–94. PMID 25831025. doi:10.3109/14756366.2015.1021252. 

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