Play Video
1
WereAllTrue TPM1
WereAllTrue TPM1
::2014/06/24::
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2
WereAllTrue TPM1
WereAllTrue TPM1
::2014/06/24::
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3
TPM1 pneumatic crimping head
TPM1 pneumatic crimping head
::2013/07/18::
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4
TPM1 - PERFUME PNEUMATIC CRIMPING HEAD - semi auto glass bottle crimping machine perfume crimping
TPM1 - PERFUME PNEUMATIC CRIMPING HEAD - semi auto glass bottle crimping machine perfume crimping
::2012/05/23::
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5
WereAllTrue TPM1 Response - RazR Neon
WereAllTrue TPM1 Response - RazR Neon
::2014/06/18::
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6
WEREALLTRUE TPM1
WEREALLTRUE TPM1
::2014/06/28::
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7
Werealltrue TPM1
Werealltrue TPM1
::2014/07/06::
Play Video
8
putih abu abu smk n 3 oku 2012 (tpm1) part 2.wmv
putih abu abu smk n 3 oku 2012 (tpm1) part 2.wmv
::2012/05/20::
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9
WereAllTrue Private Match Challenge #TPM1
WereAllTrue Private Match Challenge #TPM1
::2014/06/24::
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10
TPM1
TPM1
::2013/07/23::
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11
TPM1
TPM1
::2007/11/26::
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12
Amispoppia-Call On Me (TPM1 Remix) *Party Hard* ᴴᴰ
Amispoppia-Call On Me (TPM1 Remix) *Party Hard* ᴴᴰ
::2013/05/12::
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13
PUTIH  abu abu smk n 3 oku 2012 (tpm1) part 3.wmv
PUTIH abu abu smk n 3 oku 2012 (tpm1) part 3.wmv
::2012/05/20::
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14
飞龙狗舍 tpm1
飞龙狗舍 tpm1
::2014/07/31::
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15
tpm1.MOV
tpm1.MOV
::2010/04/02::
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16
putih abu abu smk n 3 oku 2012 (tpm1).wmv
putih abu abu smk n 3 oku 2012 (tpm1).wmv
::2012/05/20::
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17
saat gila tpm1 baturaja
saat gila tpm1 baturaja
::2013/01/27::
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18
tpm1.mov
tpm1.mov
::2010/06/04::
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19
TPM1(SMK NEGERI 3 OKU).wmv
TPM1(SMK NEGERI 3 OKU).wmv
::2011/04/25::
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20
Rsbi tpm1 menggila1
Rsbi tpm1 menggila1
::2012/01/27::
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21
BPPKT TPM1 Harlem Shake
BPPKT TPM1 Harlem Shake
::2013/05/31::
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22
Geng Motor TPm1 Smk N 1 Gempol
Geng Motor TPm1 Smk N 1 Gempol
::2012/06/21::
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23
TPM1
TPM1
::2012/04/28::
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24
AREG " TPM1
AREG " TPM1
::2013/06/01::
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25
Motor Touring TPm1 smkn 1 Gempol
Motor Touring TPm1 smkn 1 Gempol
::2012/06/21::
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26
Maísa Martins tpm1
Maísa Martins tpm1
::2011/06/01::
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27
TPM1
TPM1
::2010/10/29::
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28
X Tpm1 Syuper Soccer.3gp
X Tpm1 Syuper Soccer.3gp
::2012/05/13::
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29
TPM1.avi
TPM1.avi
::2012/02/17::
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30
Test kratkog spoja TPM1-2KLP.avi
Test kratkog spoja TPM1-2KLP.avi
::2011/11/20::
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31
SagaTPM - Episódio 1 - Malditas maçãs!
SagaTPM - Episódio 1 - Malditas maçãs!
::2012/02/18::
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32
TPM 1
TPM 1
::2009/09/13::
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33
★ Let
★ Let's Design AutoCAD Mechanical #1 - Extrudedichtung [HD] Part 1
::2013/12/21::
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34
KR4 Midseason Report
KR4 Midseason Report
::2013/08/18::
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35
Fourth of July in Seaworld
Fourth of July in Seaworld
::2013/07/05::
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36
WereAllTrue Challenge shot response
WereAllTrue Challenge shot response
::2014/07/11::
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37
Chamblon2012_jnicolet_course1_et_essai2
Chamblon2012_jnicolet_course1_et_essai2
::2012/06/21::
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38
virada de ano (2012)MONTE  SIÃO DE CARAPINA
virada de ano (2012)MONTE SIÃO DE CARAPINA
::2012/01/02::
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39
Aulas de dança com LILIAN & CAMILA !   Alunas   ALDACI & IRENE
Aulas de dança com LILIAN & CAMILA ! Alunas ALDACI & IRENE
::2009/11/14::
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40
1708164223
1708164223
::2013/08/17::
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41
310674
310674
::2012/07/19::
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42
★ Let
★ Let's Design AutoCAD Mechanical #2 - Extrudedichtung [HD] Part 2
::2013/12/21::
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43
b2b 26300
b2b 26300
::2008/09/06::
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44
TPM2 Full
TPM2 Full
::2013/12/22::
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45
Pego de surpresa
Pego de surpresa
::2010/11/01::
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46
Palukka sejati
Palukka sejati
::2013/05/31::
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47
Blits Jowo
Blits Jowo
::2012/06/21::
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48
Phone Rings Goodbye (long edit) by Brenton Duvall
Phone Rings Goodbye (long edit) by Brenton Duvall
::2012/12/07::
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49
PANASONIC CF 19 FOR SALE
PANASONIC CF 19 FOR SALE
::2010/10/03::
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50
DE TUDO UM POUCO - Como lidar com a TPM? 1/2
DE TUDO UM POUCO - Como lidar com a TPM? 1/2
::2013/11/14::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Tropomyosin 1 (alpha)
Protein TPM1 PDB 1c1g.png
PDB rendering based on 1c1g.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TPM1 ; C15orf13; CMD1Y; CMH3; HTM-alpha; LVNC9; TMSA
External IDs OMIM191010 MGI98809 HomoloGene121635 GeneCards: TPM1 Gene
RNA expression pattern
PBB GE TPM1 210986 s at tn.png
PBB GE TPM1 206116 s at tn.png
PBB GE TPM1 210987 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7168 22003
Ensembl ENSG00000140416 ENSMUSG00000032366
UniProt P09493 Q545Y3
RefSeq (mRNA) NM_000366 NM_024427
RefSeq (protein) NP_000357 NP_077745
Location (UCSC) Chr 15:
63.33 – 63.36 Mb
Chr 9:
66.82 – 66.85 Mb
PubMed search [1] [2]

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene.[1]

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.[2]

Interactions[edit]

TPM1 has been shown to interact with TPM2.[3]

References[edit]

  1. ^ Mogensen J, Kruse TA, Borglum AD (Jun 1999). "Refined localization of the human alpha-tropomyosin gene (TPM1) by genetic mapping". Cytogenet Cell Genet 84 (1-2): 35–6. doi:10.1159/000015207. PMID 10343096. 
  2. ^ "Entrez Gene: TPM1 tropomyosin 1 (alpha)". 
  3. ^ Brown, H R; Schachat F H (Apr 1985). "Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 82 (8): 2359–63. doi:10.1073/pnas.82.8.2359. ISSN 0027-8424. PMC 397557. PMID 3857586. 

Further reading[edit]

External links[edit]


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