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RESULTS [51 .. 101]
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TRIO and F-actin binding protein
Identifiers
Symbols TRIOBP ; DFNB28; TAP68; TARA; dJ37E16.4
External IDs OMIM609761 MGI1349410 HomoloGene5104 GeneCards: TRIOBP Gene
Orthologs
Species Human Mouse
Entrez 11078 110253
Ensembl ENSG00000100106 ENSMUSG00000033088
UniProt Q9H2D6 Q99KW3
RefSeq (mRNA) NM_001039141 NM_001024716
RefSeq (protein) NP_001034230 NP_001019887
Location (UCSC) Chr 22:
38.09 – 38.17 Mb
Chr 15:
78.95 – 79.01 Mb
PubMed search [1] [2]

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.[1][2][3][4]

This gene encodes a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility, and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal-recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).[4]

References[edit]

  1. ^ Seipel K, O'Brien SP, Iannotti E, Medley QG, Streuli M (Jan 2001). "Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization". J Cell Sci 114 (Pt 2): 389–99. PMID 11148140. 
  2. ^ Riazuddin S, Khan SN, Ahmed ZM, Ghosh M, Caution K, Nazli S, Kabra M, Zafar AU, Chen K, Naz S, Antonellis A, Pavan WJ, Green ED, Wilcox ER, Friedman PL, Morell RJ, Riazuddin S, Friedman TB (Dec 2005). "Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness". Am J Hum Genet 78 (1): 137–43. doi:10.1086/499164. PMC 1380211. PMID 16385457. 
  3. ^ Shahin H, Walsh T, Sobe T, Abu Sa'ed J, Abu Rayan A, Lynch ED, Lee MK, Avraham KB, King MC, Kanaan M (Dec 2005). "Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss". Am J Hum Genet 78 (1): 144–52. doi:10.1086/499495. PMC 1380212. PMID 16385458. 
  4. ^ a b "Entrez Gene: TRIOBP TRIO and F-actin binding protein". 

Further reading[edit]



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