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Tubulin, alpha 1a
Protein TUBA1A PDB 1ffx.png
PDB rendering based on 1ffx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TUBA1A ; B-ALPHA-1; LIS3; TUBA3
External IDs OMIM602529 MGI98869 HomoloGene68498 ChEMBL: 3661 GeneCards: TUBA1A Gene
RNA expression pattern
PBB GE TUBA1A 209118 s at tn.png
PBB GE TUBA1A 201090 x at tn.png
PBB GE TUBA1A 209251 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7846 22142
Ensembl ENSG00000167552 ENSMUSG00000072235
UniProt Q71U36 P68369
RefSeq (mRNA) NM_001270399 NM_011653
RefSeq (protein) NP_001257328 NP_035783
Location (UCSC) Chr 12:
49.58 – 49.58 Mb
Chr 15:
98.95 – 98.95 Mb
PubMed search [1] [2]

Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene.[1][2][3]

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.[3]

Interactions[edit]

TUBA1A has been shown to interact with PAFAH1B1.[4]

References[edit]

  1. ^ Crabtree DV, Ojima I, Geng X, Adler AJ (August 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorg Med Chem 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633. 
  2. ^ Hall JL, Cowan NJ (July 1985). "Structural features and restricted expression of a human alpha-tubulin gene". Nucleic Acids Res 13 (1): 207–23. doi:10.1093/nar/13.1.207. PMC 340985. PMID 3839072. 
  3. ^ a b "Entrez Gene: TUBA1A tubulin, alpha 1a". 
  4. ^ Sapir, T; Elbaum M, Reiner O (December 1997). "Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit". EMBO J. (ENGLAND) 16 (23): 6977–84. doi:10.1093/emboj/16.23.6977. ISSN 0261-4189. PMC 1170301. PMID 9384577. 

Further reading[edit]



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