Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
^Crabtree DV, Ojima I, Geng X, Adler AJ (August 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorg Med Chem9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID11504633.
Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol. Cell. Biol.3 (10): 1738–45. PMC370035. PMID6646120.
Alexandrova N, Niklinski J, Bliskovsky V, et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Mol. Cell. Biol.15 (9): 5188–95. PMC230766. PMID7651436.
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID11146551.
Payton JE, Perrin RJ, Clayton DF, George JM (2002). "Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells". Brain Res. Mol. Brain Res.95 (1–2): 138–45. doi:10.1016/S0169-328X(01)00257-1. PMID11687285.
Bifulco M, Laezza C, Stingo S, Wolff J (2002). "2′,3′-Cyclic nucleotide 3′-phosphodiesterase: A membrane-bound, microtubule-associated protein and membrane anchor for tubulin". Proc. Natl. Acad. Sci. U.S.A.99 (4): 1807–12. doi:10.1073/pnas.042678799. PMC122275. PMID11842207.