Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4Agene.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
^Zumbrunn, J; Kinoshita K, Hyman A A, Näthke I S (January 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Curr. Biol. (England) 11 (1): 44–9. doi:10.1016/S0960-9822(01)00002-1. ISSN0960-9822. PMID11166179.Cite uses deprecated parameters (help)
Yamaguchi N, Fukuda MN (1995). "Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins.". J. Biol. Chem.270 (20): 12170–6. doi:10.1074/jbc.270.33.19551. PMID7744867.
Lu Q, Luduena RF (1994). "In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins.". J. Biol. Chem.269 (3): 2041–7. PMID8294455.
Paschal BM, Holzbaur EL, Pfister KK, et al. (1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin.". J. Biol. Chem.268 (20): 15318–23. PMID8325901.
Huby RD, Carlile GW, Ley SC (1996). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells.". J. Biol. Chem.270 (51): 30241–4. doi:10.1074/jbc.270.51.30241. PMID8530437.
Marie-Cardine A, Kirchgessner H, Eckerskorn C, et al. (1996). "Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase.". Eur. J. Immunol.25 (12): 3290–7. doi:10.1002/eji.1830251214. PMID8566014.
Peters JD, Furlong MT, Asai DJ, et al. (1996). "Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine.". J. Biol. Chem.271 (9): 4755–62. doi:10.1074/jbc.271.9.4755. PMID8617742.
Vaillant AR, Müller R, Langkopf A, Brown DL (1998). "Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics.". J. Biol. Chem.273 (22): 13973–81. doi:10.1074/jbc.273.22.13973. PMID9593747.