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TUBA 4 A
TUBA 4 A
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Tubulin, alpha 4a
Protein TUBA4A PDB 1ffx.png
PDB rendering based on 1ffx.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TUBA4A ; H2-ALPHA; TUBA1
External IDs OMIM191110 MGI1095410 HomoloGene68496 ChEMBL: 2070 GeneCards: TUBA4A Gene
RNA expression pattern
PBB GE TUBA4A 212242 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7277 22145
Ensembl ENSG00000127824 ENSMUSG00000026202
UniProt P68366 P68368
RefSeq (mRNA) NM_006000 NM_009447
RefSeq (protein) NP_005991 NP_033473
Location (UCSC) Chr 2:
220.11 – 220.14 Mb
Chr 1:
75.21 – 75.22 Mb
PubMed search [1] [2]

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene.[1]

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.[2]

Interactions[edit]

TUBA4A has been shown to interact with NCOA6[3] and APC.[4]

References[edit]

  1. ^ Villasante A, Wang D, Dobner P, Dolph P, Lewis SA, Cowan NJ (January 1987). "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes". Mol Cell Biol 6 (7): 2409–19. PMC 367794. PMID 3785200. 
  2. ^ "Entrez Gene: TUBA4A tubulin, alpha 4a". 
  3. ^ Goo, Young-Hwa; Sohn Young Chang, Kim Dae-Hwan, Kim Seung-Whan, Kang Min-Jung, Jung Dong-Ju, Kwak Eunyee, Barlev Nickolai A, Berger Shelley L, Chow Vincent T, Roeder Robert G, Azorsa David O, Meltzer Paul S, Suh Pan-Gil, Song Eun Joo, Lee Kong-Joo, Lee Young Chul, Lee Jae Woon (January 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Mol. Cell. Biol. (United States) 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. ISSN 0270-7306. PMC 140670. PMID 12482968. 
  4. ^ Zumbrunn, J; Kinoshita K; Hyman A A; Näthke I S (January 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Curr. Biol. (England) 11 (1): 44–9. doi:10.1016/S0960-9822(01)00002-1. ISSN 0960-9822. PMID 11166179. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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