SPONSORED VIDEO
Play Video
1
Jpx RNA Activates Xist by Evicting CTCF
Jpx RNA Activates Xist by Evicting CTCF
::2013/06/10::
Play Video
2
rubik twist como hacer la tortuga
rubik twist como hacer la tortuga
::2012/01/02::
Play Video
3
HIF skit for Burke Retreat 2011.MOV
HIF skit for Burke Retreat 2011.MOV
::2011/09/15::
Play Video
4
Twist song - Love Aaj Kal
Twist song - Love Aaj Kal
::2012/01/20::
Play Video
5
Twist 1
Twist 1
::2013/12/15::
Play Video
6
Twist @ Dome
Twist @ Dome
::2012/01/30::
Play Video
7
Twist song - Love Aaj Kal
Twist song - Love Aaj Kal
::2011/11/04::
Play Video
8
How can genes be used to repair of cartilage... the answer coming up next
How can genes be used to repair of cartilage... the answer coming up next
::2013/05/02::
Play Video
9
West End Blues - Louis Armstrong
West End Blues - Louis Armstrong
::2007/02/08::
Play Video
10
Kim Possible Full Episodes Season 1 Episode 17 The Twin Factor
Kim Possible Full Episodes Season 1 Episode 17 The Twin Factor
::2015/01/18::
Play Video
11
[subtitles] Eugene The Librarian (HQ) Britain
[subtitles] Eugene The Librarian (HQ) Britain's Got Talent 2009
::2009/05/17::
Play Video
12
Simulated Supercoiling in Prokaryotic DNA
Simulated Supercoiling in Prokaryotic DNA
::2011/05/30::
Play Video
13
Philip Green shows off his impressions and dance moves! | Semi-Final 1 | Britain
Philip Green shows off his impressions and dance moves! | Semi-Final 1 | Britain's Got Talent 2013
::2013/05/27::
Play Video
14
Showtime
Showtime's Caindoy family does acoustic comedy
::2012/10/20::
Play Video
15
Jackson 5- Give me one more chance (i want you back)
Jackson 5- Give me one more chance (i want you back)
::2013/09/10::
Play Video
16
SiX DwArF - This Troublemaker Love (Olly Murs Maroon 5 2013 mix)
SiX DwArF - This Troublemaker Love (Olly Murs Maroon 5 2013 mix)
::2013/01/28::
Play Video
17
Augmented Reality of flexible DNA with ambient occlusion (SSAO)
Augmented Reality of flexible DNA with ambient occlusion (SSAO)
::2011/09/26::
Play Video
18
Mozart   Sinfonia n  51 in Do maggiore
Mozart Sinfonia n 51 in Do maggiore
::2014/05/09::
Play Video
19
Gomorrah - Garcia/Hunter
Gomorrah - Garcia/Hunter
::2007/03/15::
Play Video
20
Dan Gilbert: The surprising science of happiness
Dan Gilbert: The surprising science of happiness
::2012/04/26::
Play Video
21
Silent Night - Be vewy, vewy quiet (Bob Evans)
Silent Night - Be vewy, vewy quiet (Bob Evans)
::2010/12/13::
Play Video
22
Demi Lovato Rehab Rumors, Simon Cowell
Demi Lovato Rehab Rumors, Simon Cowell's Next Show, & Demi Moore Hospitalized
::2012/01/25::
Play Video
23
Fibroid Tumors- What are they?
Fibroid Tumors- What are they?
::2009/05/08::
Play Video
24
youve got the love acoustic cover with harmonica-  funky instrumental
youve got the love acoustic cover with harmonica- funky instrumental
::2010/12/13::
Play Video
25
Snooki Gives Birth to Baby Boy Lorenzo Dominic & Sabrina Bryan Joins DWTS: All Star Season
Snooki Gives Birth to Baby Boy Lorenzo Dominic & Sabrina Bryan Joins DWTS: All Star Season
::2012/08/27::
Play Video
26
One Life to Live
One Life to Live's David A. Gregory to Guest Star on Gossip Girl
::2012/02/08::
Play Video
27
How to automatically transcribe voice notes for Evernote, Catch, and other apps on Android
How to automatically transcribe voice notes for Evernote, Catch, and other apps on Android
::2013/06/12::
Play Video
28
Uric Acid(Rheumatoid arthritis ) in Amharic
Uric Acid(Rheumatoid arthritis ) in Amharic
::2012/08/05::
Play Video
29
IPA Data Analysis Part 1
IPA Data Analysis Part 1
::2013/10/15::
Play Video
30
Worst NHL Contracts Ever--FUNNY!!
Worst NHL Contracts Ever--FUNNY!!
::2014/09/16::
Play Video
31
Roy Hargrove - Soulful - Auvernier Jazz Festival 2009
Roy Hargrove - Soulful - Auvernier Jazz Festival 2009
::2013/10/25::
Play Video
32
The PI3K/AKT signalling pathway
The PI3K/AKT signalling pathway
::2010/02/22::
Play Video
33
King Of  The Swingers        JAZZ..
King Of The Swingers JAZZ..
::2013/11/01::
Play Video
34
I Want To Dance With Somebody - Whitney Houston Drum Track
I Want To Dance With Somebody - Whitney Houston Drum Track
::2013/09/04::
Play Video
35
BEAT HAZARD - Kings and Queens by 30 Seconds to Mars
BEAT HAZARD - Kings and Queens by 30 Seconds to Mars
::2012/01/13::
Play Video
36
Identification and Function of Ets Target Genes Involved in Lung Cancer Progression
Identification and Function of Ets Target Genes Involved in Lung Cancer Progression
::2013/03/22::
Play Video
37
God You Are My God-Drums
God You Are My God-Drums
::2012/10/01::
Play Video
38
Huxton Creepers - King Of The Road (live 1986)
Huxton Creepers - King Of The Road (live 1986)
::2011/04/27::
Play Video
39
AD Fundão 5-1 Operário: Golo olímpico de Mário Freitas
AD Fundão 5-1 Operário: Golo olímpico de Mário Freitas
::2013/03/11::
Play Video
40
How I shrunk Fibroid tumors on a Omnivore diet?
How I shrunk Fibroid tumors on a Omnivore diet?
::2012/04/24::
Play Video
41
Lays Advert With Messi HD
Lays Advert With Messi HD
::2014/04/17::
Play Video
42
How To Play Bass To Mustang Sally (The Commitments)
How To Play Bass To Mustang Sally (The Commitments)
::2013/05/21::
Play Video
43
Acetylcholine receptor, Rate My Science
Acetylcholine receptor, Rate My Science
::2008/10/08::
Play Video
44
Harry Styles interview with Johnjay and Rich
Harry Styles interview with Johnjay and Rich
::2013/01/23::
Play Video
45
led tube wiring,led tube wiring diagram,led tube recall
led tube wiring,led tube wiring diagram,led tube recall
::2012/08/21::
Play Video
46
BO Sur la Route de Madison - Casta Diva de Bellini - Piano Cover
BO Sur la Route de Madison - Casta Diva de Bellini - Piano Cover
::2013/04/17::
Play Video
47
Paul McCartney - Chaos & Creation at Abbey Road 7/7
Paul McCartney - Chaos & Creation at Abbey Road 7/7
::2006/10/20::
Play Video
48
Distinct Filipino Sound in Contemporary Music
Distinct Filipino Sound in Contemporary Music
::2012/12/05::
Play Video
49
Midnight Hours - Try A Little Tenderness
Midnight Hours - Try A Little Tenderness
::2014/05/15::
Play Video
50
Rick K and The Allnighter - To Love Somebody
Rick K and The Allnighter - To Love Somebody
::2014/08/13::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
  (Redirected from TWIST1)
Jump to: navigation, search
Twist family bHLH transcription factor 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TWIST1 ; ACS3; BPES2; BPES3; CRS; CRS1; SCS; TWIST; bHLHa38
External IDs OMIM601622 MGI98872 HomoloGene402 GeneCards: TWIST1 Gene
RNA expression pattern
PBB GE TWIST1 213943 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7291 22160
Ensembl ENSG00000122691 ENSMUSG00000035799
UniProt Q15672 P26687
RefSeq (mRNA) NM_000474 NM_011658
RefSeq (protein) NP_000465 NP_035788
Location (UCSC) Chr 7:
19.06 – 19.16 Mb
Chr 12:
33.96 – 33.96 Mb
PubMed search [1] [2]

Twist-related protein 1 (TWIST1) also known as class A basic helix-loop-helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene.[1][2]

Function[edit]

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1 (a.k.a. TWIST2). The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially.[3]

Twist1 is thought to regulate osteogenic lineage.[4]

Clinical significance[edit]

Mutations in the TWIST1 gene are associated with Saethre-Chotzen syndrome,[5][6] breast cancer,[7] and Sézary Syndrome.[8]

As an oncogene[edit]

Twist plays an essential role in cancer metastasis. Over-expression of Twist or methylation of its promoter is common in metastatic carcinomas. Hence targeting Twist has a great promise as a cancer therapeutic.[9] In cooperation with N-Myc, Twist-1 acts as an oncogene in several cancers including neuroblastoma.[7][10]

Twist is activated by a variety of signal transduction pathways, including Akt, signal transducer and activator of transcription 3 (STAT3), mitogen-activated protein kinase, Ras, and Wnt signaling. Activated Twist upregulates N-cadherin and downregulates E-cadherin, which are the hallmarks of EMT. Moreover, Twist plays an important role in some physiological processes involved in metastasis, like angiogenesis, invadopodia, extravasation, and chromosomal instability. Twist also protects cancer cells from apoptotic cell death. In addition, Twist is responsible for the maintenance of cancer stem cells and the development of chemotherapy resistance.[9] Twist1 is extensively studied for its role in head- and neck cancers.[11] Here, Twist1 has been shown to be involved in evading apoptosis, making the tumour cells resistant against chemotherapeutic drugs like cisplatin.[12] Moreover, Twist1 has been shown to be expressed under conditions of hypoxia, corresponding to the observation that hypoxic cells respond less to chemotherapeutic drugs.[11]

Another process in which Twist 1 is involved is tumour metastasis. The underlying mechanism is not completely understood, but it has been implicated in the upregulation of matrix metalloproteinases[13] and inhibition of TIMP.[14]

Recently, targeting Twist has gained interest as a target for cancer therapeutics. The inactivation of Twist by small interfering RNA or chemotherapeutic approach has been demonstrated in vitro. Moreover, several inhibitors which are antagonistic to the upstream or downstream molecules of Twist signaling pathways have also been identified.[9]

Interactions[edit]

Twist transcription factor has been shown to interact with EP300,[15] TCF3[16] and PCAF.[15]

See also[edit]

References[edit]

  1. ^ Bourgeois P, Stoetzel C, Bolcato-Bellemin AL, Mattei MG, Perrin-Schmitt F (December 1996). "The human H-twist gene is located at 7p21 and encodes a B-HLH protein that is 96% similar to its murine M-twist counterpart". Mamm. Genome 7 (12): 915–7. doi:10.1007/s003359900269. PMID 8995765. 
  2. ^ Dollfus H, Kumaramanickavel G, Biswas P, Stoetzel C, Quillet R, Denton M, Maw M, Perrin-Schmitt F (July 2001). "Identification of a new TWIST mutation (7p21) with variable eyelid manifestations supports locus homogeneity of BPES at 3q22". J. Med. Genet. 38 (7): 470–2. doi:10.1136/jmg.38.7.470. PMC 1757180. PMID 11474656. 
  3. ^ "Entrez Gene: TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)". 
  4. ^ Lee MS, Lowe GN, Strong DD, Wergedal JE, Glackin CA (December 1999). "TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage". J. Cell. Biochem. 75 (4): 566–77. doi:10.1002/(SICI)1097-4644(19991215)75:4<566::AID-JCB3>3.0.CO;2-0. PMID 10572240. 
  5. ^ Kress W, Schropp C, Lieb G, Petersen B, Büsse-Ratzka M, Kunz J, Reinhart E, Schäfer WD, Sold J, Hoppe F, Pahnke J, Trusen A, Sörensen N, Krauss J, Collmann H (January 2006). "Saethre-Chotzen syndrome caused by TWIST 1 gene mutations: functional differentiation from Muenke coronal synostosis syndrome". Eur. J. Hum. Genet. 14 (1): 39–48. doi:10.1038/sj.ejhg.5201507. PMID 16251895. 
  6. ^ Howard TD, Paznekas WA, Green ED, Chiang LC, Ma N, Ortiz de Luna RI, Garcia Delgado C, Gonzalez-Ramos M, Kline AD, Jabs EW (January 1997). "Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome". Nat. Genet. 15 (1): 36–41. doi:10.1038/ng0197-36. PMID 8988166. 
  7. ^ a b Martin TA, Goyal A, Watkins G, Jiang WG (June 2005). "Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer". Ann. Surg. Oncol. 12 (6): 488–96. doi:10.1245/ASO.2005.04.010. PMID 15864483. 
  8. ^ van Doorn R, Dijkman R, Vermeer MH, Out-Luiting JJ, van der Raaij-Helmer EM, Willemze R, Tensen CP (August 2004). "Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis". Cancer Res. 64 (16): 5578–86. doi:10.1158/0008-5472.CAN-04-1253. PMID 15313894. 
  9. ^ a b c Khan MA, Chen HC, Zhang D, Fu J (July 2013). "Twist: a molecular target in cancer therapeutics". Tumour Biol. 34 (5): 2497–506. doi:10.1007/s13277-013-1002-x. PMID 23873099. 
  10. ^ Puisieux A, Valsesia-Wittmann S, Ansieau S (January 2006). "A twist for survival and cancer progression". Br. J. Cancer 94 (1): 13–7. doi:10.1038/sj.bjc.6602876. PMC 2361066. PMID 16306876. 
  11. ^ a b Wu KJ, Yang MH (December 2011). "Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection". Biosci. Rep. 31 (6): 449–55. doi:10.1042/BSR20100114. PMID 21919891. 
  12. ^ Zhuo WL, Wang Y, Zhuo XL, Zhang YS, Chen ZT (May 2008). "Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathway". Biochem. Biophys. Res. Commun. 369 (4): 1098–102. doi:10.1016/j.bbrc.2008.02.143. PMID 18331824. 
  13. ^ Zhao XL, Sun T, Che N, Sun D, Zhao N, Dong XY, Gu Q, Yao Z, Sun BC (March 2011). "Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator Twist1". J. Cell. Mol. Med. 15 (3): 691–700. doi:10.1111/j.1582-4934.2010.01052.x. PMID 20219012. 
  14. ^ Okamura H, Yoshida K, Haneji T (July 2009). "Negative regulation of TIMP1 is mediated by transcription factor TWIST1". Int. J. Oncol. 35 (1): 181–6. doi:10.3892/ijo_00000327. PMID 19513566. 
  15. ^ a b Hamamori Y, Sartorelli V, Ogryzko V, Puri PL, Wu HY, Wang JY, Nakatani Y, Kedes L (February 1999). "Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A". Cell 96 (3): 405–13. doi:10.1016/S0092-8674(00)80553-X. PMID 10025406. 
  16. ^ El Ghouzzi V, Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, Bonaventure J (March 2000). "Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location". Hum. Mol. Genet. 9 (5): 813–9. doi:10.1093/hmg/9.5.813. PMID 10749989. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Wikipedia content is licensed under the GFDL License
Powered by YouTube
MASHPEDIA
LEGAL
  • Mashpedia © 2014