Play Video
1
Troponin I Serum/Whole Blood Rapid Test (Cassette)
Troponin I Serum/Whole Blood Rapid Test (Cassette)
::2013/09/19::
Play Video
2
Troponin 1: Cardiac Regulatory Protein
Troponin 1: Cardiac Regulatory Protein
::2010/07/30::
Play Video
3
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/02/15::
Play Video
4
Troponin I ELISA kit
Troponin I ELISA kit
::2010/06/09::
Play Video
5
ZBx Cardiac Troponin I Rapid Test
ZBx Cardiac Troponin I Rapid Test
::2012/11/22::
Play Video
6
Video Clip bioNexia Troponin I
Video Clip bioNexia Troponin I
::2012/08/18::
Play Video
7
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
::2011/10/14::
Play Video
8
Troponin and MI 1
Troponin and MI 1
::2013/04/24::
Play Video
9
Troponin Test
Troponin Test
::2012/02/03::
Play Video
10
Coding Elevated Troponin
Coding Elevated Troponin
::2013/06/11::
Play Video
11
Don
Don't blame it on the troponin
::2011/06/15::
Play Video
12
Troponin I Domino
Troponin I Domino
::2012/08/07::
Play Video
13
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
::2012/01/31::
Play Video
14
Troponin after Non-cardiac Surgery Predicts Bad Outcome
Troponin after Non-cardiac Surgery Predicts Bad Outcome
::2012/07/03::
Play Video
15
troponin.mp4
troponin.mp4
::2011/10/17::
Play Video
16
troponin show
troponin show
::2014/02/14::
Play Video
17
High sensitivity troponin T and AMI with Dr. Martin Holzmann
High sensitivity troponin T and AMI with Dr. Martin Holzmann
::2014/04/03::
Play Video
18
Troponin and MI 6
Troponin and MI 6
::2013/04/24::
Play Video
19
Troponin T Release After Rapid Pacing
Troponin T Release After Rapid Pacing
::2011/06/10::
Play Video
20
Dr. Vipin Bhayana - High Sensitivity Troponins: A change in practice
Dr. Vipin Bhayana - High Sensitivity Troponins: A change in practice
::2012/01/21::
Play Video
21
Singulex High-Definition Troponin Testing Part 4 - CVMedHome Wellness Program
Singulex High-Definition Troponin Testing Part 4 - CVMedHome Wellness Program
::2011/10/24::
Play Video
22
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
::2011/10/24::
Play Video
23
ZZS Troponin post PCI
ZZS Troponin post PCI
::2011/07/28::
Play Video
24
Singulex High-Definition Troponin Testing Part 2 - Sgx HD cTnI Test
Singulex High-Definition Troponin Testing Part 2 - Sgx HD cTnI Test
::2011/10/24::
Play Video
25
原肌凝蛋白和肌钙蛋白及它们在肌肉收缩时扮演的角色 Tropomyosin and troponin and their role in regulating muscle contraction
原肌凝蛋白和肌钙蛋白及它们在肌肉收缩时扮演的角色 Tropomyosin and troponin and their role in regulating muscle contraction
::2014/01/17::
Play Video
26
Troponin and MI 7
Troponin and MI 7
::2013/04/24::
Play Video
27
SENSATIVE TEST FOR HEART ATTACK , TROPONIN , HEALTH EDUCATION , ICSP , URDU / HINDI .
SENSATIVE TEST FOR HEART ATTACK , TROPONIN , HEALTH EDUCATION , ICSP , URDU / HINDI .
::2012/01/14::
Play Video
28
How a muscle contraction is signalled - Animation
How a muscle contraction is signalled - Animation
::2009/02/04::
Play Video
29
Troponin in HF, MI post-op, ROMICAT II
Troponin in HF, MI post-op, ROMICAT II
::2012/07/26::
Play Video
30
Tropomyosin and troponin.flv
Tropomyosin and troponin.flv
::2010/09/20::
Play Video
31
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/10/05::
Play Video
32
Meritas - Your Best Decision at Point of Care
Meritas - Your Best Decision at Point of Care
::2013/11/28::
Play Video
33
Cardiac markers blood test
Cardiac markers blood test
::2010/04/23::
Play Video
34
troponin-C Пикотехнологическая модель белка тропонин-Ц
troponin-C Пикотехнологическая модель белка тропонин-Ц
::2014/01/15::
Play Video
35
3 in 1 rapidtest kit
3 in 1 rapidtest kit
::2013/09/19::
Play Video
36
Sliding Filament Theory.wmv
Sliding Filament Theory.wmv
::2011/07/29::
Play Video
37
Vista Therapeutics NanoBioSensor Introduction and Demo using PSA and Troponin NanoCards.MP4
Vista Therapeutics NanoBioSensor Introduction and Demo using PSA and Troponin NanoCards.MP4
::2012/01/15::
Play Video
38
Troponine test:  hartaanvallen
Troponine test: hartaanvallen
::2013/09/05::
Play Video
39
Singulex High-Definition Troponin Testing Part 3 - Advanced Lipid Panel
Singulex High-Definition Troponin Testing Part 3 - Advanced Lipid Panel
::2011/10/24::
Play Video
40
Homo-Dimer Troponin-C site III (1CTA) binding
Homo-Dimer Troponin-C site III (1CTA) binding
::2011/12/27::
Play Video
41
How to Pronounce Troponin
How to Pronounce Troponin
::2013/11/21::
Play Video
42
Heart Attack Blood Test: Troponin
Heart Attack Blood Test: Troponin
::2014/01/22::
Play Video
43
"Know Your Heart Series", Diagnostic Testing, Blood Tests
"Know Your Heart Series", Diagnostic Testing, Blood Tests
::2011/02/24::
Play Video
44
MagBiosense
MagBiosense's revolutionary heart-attack diagnostic device - 3rd place 2014 SPIE Startup Challenge
::2014/02/13::
Play Video
45
Clinical use of Cardiac Troponin T
Clinical use of Cardiac Troponin T
::2013/03/18::
Play Video
46
Innovations In Point-of-Care Testing For Enhanced United States Disaster Caches
Innovations In Point-of-Care Testing For Enhanced United States Disaster Caches
::2013/06/29::
Play Video
47
AQT90 FLEX immunoassay analyzer
AQT90 FLEX immunoassay analyzer
::2010/09/03::
Play Video
48
"Biochemistry", The Interaction of Calcium Ion with Troponin C
"Biochemistry", The Interaction of Calcium Ion with Troponin C
::2012/06/07::
Play Video
49
Cardiac Markers Lecture 1 By Dr.Leroy Rebello
Cardiac Markers Lecture 1 By Dr.Leroy Rebello
::2012/12/23::
Play Video
50
An International Prespective On The Role of Point-of-Care Testing in Disaster Management - Part 2
An International Prespective On The Role of Point-of-Care Testing in Disaster Management - Part 2
::2013/05/28::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Troponin

Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

The tissue specific subtypes are:

  • Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042)
  • Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043)
  • Cardiac troponin I, TNNI3 (19q13.4, 191044)

cTnI[edit]

Human troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. The theoretical pI of cTnI is 9.87. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein – one dephospho, two monophospho and one bisphospho – can coexist in the cell. Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. According to the latest findings significant part of cTnI released into the patient’s blood stream is phosphorylated.[1] For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the “golden marker” of last decades – Creatin Kinase, as well as myoglobin and lactate dehydrogenase isoenzymes.

See also[edit]

External links[edit]

References[edit]

  1. ^ Labugger R, Organ L, Collier C, Atar D, Van Eyk JE (2000). "Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction". Circulation. 102 (11): 1221–1226. 


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