Play Video
1
Troponin I Serum/Whole Blood Rapid Test (Cassette)
Troponin I Serum/Whole Blood Rapid Test (Cassette)
::2013/09/19::
Play Video
2
Troponin 1: Cardiac Regulatory Protein
Troponin 1: Cardiac Regulatory Protein
::2010/07/30::
Play Video
3
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/02/15::
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4
ZBx Cardiac Troponin I Rapid Test
ZBx Cardiac Troponin I Rapid Test
::2012/11/22::
Play Video
5
Troponin I ELISA kit
Troponin I ELISA kit
::2010/06/09::
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6
Video Clip bioNexia Troponin I
Video Clip bioNexia Troponin I
::2012/08/18::
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7
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
::2011/10/14::
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8
Troponin and MI 1
Troponin and MI 1
::2013/04/24::
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9
Coding Elevated Troponin
Coding Elevated Troponin
::2013/06/11::
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10
Troponin I Domino
Troponin I Domino
::2012/08/07::
Play Video
11
Meritas - Your Best Decision at Point of Care
Meritas - Your Best Decision at Point of Care
::2013/11/28::
Play Video
12
3 in 1 rapidtest kit
3 in 1 rapidtest kit
::2013/09/19::
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13
Heart Attack Blood Test: Troponin
Heart Attack Blood Test: Troponin
::2014/01/22::
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14
Troponin Test
Troponin Test
::2012/02/03::
Play Video
15
Clinical use of Cardiac Troponin T
Clinical use of Cardiac Troponin T
::2013/03/18::
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16
Don
Don't blame it on the troponin
::2011/06/15::
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17
AQT90 FLEX immunoassay analyzer
AQT90 FLEX immunoassay analyzer
::2010/09/03::
Play Video
18
Eurolyser smart - Your point of care center
Eurolyser smart - Your point of care center
::2012/10/25::
Play Video
19
Troponin
Troponin
::2013/03/30::
Play Video
20
Hs-Troponin T, Silent Cerebral Ischemia and Complications in Afib
Hs-Troponin T, Silent Cerebral Ischemia and Complications in Afib
::2013/07/11::
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21
Initial Troponin & Early Changes Differentiate Chest Pain Pts
Initial Troponin & Early Changes Differentiate Chest Pain Pts
::2013/09/27::
Play Video
22
Troponin
Troponin
::2013/05/02::
Play Video
23
High-Sensitivity Troponin as a Biomarker: A PLATO Substudy
High-Sensitivity Troponin as a Biomarker: A PLATO Substudy
::2012/12/17::
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24
Troponin after Non-cardiac Surgery Predicts Bad Outcome
Troponin after Non-cardiac Surgery Predicts Bad Outcome
::2012/07/03::
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25
High sensitivity troponin T and AMI with Dr. Martin Holzmann
High sensitivity troponin T and AMI with Dr. Martin Holzmann
::2014/04/03::
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26
troponin.mp4
troponin.mp4
::2011/10/17::
Play Video
27
Dr. Allan Jaffe Discusses hs-Troponin at ACC.14
Dr. Allan Jaffe Discusses hs-Troponin at ACC.14
::2014/04/04::
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28
Headache and ACS
Headache and ACS
::2012/12/21::
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29
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
::2012/01/31::
Play Video
30
Troponin and MI 3
Troponin and MI 3
::2013/04/24::
Play Video
31
"Know Your Heart Series", Diagnostic Testing, Blood Tests
"Know Your Heart Series", Diagnostic Testing, Blood Tests
::2011/02/24::
Play Video
32
Troponin and MI 5
Troponin and MI 5
::2013/04/24::
Play Video
33
SAH-Induced Cardiomyopathy - During
SAH-Induced Cardiomyopathy - During
::2008/08/02::
Play Video
34
Tropomyosin and troponin.flv
Tropomyosin and troponin.flv
::2010/09/20::
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35
Allan Jaffe - Monitoring for Chemotherapy Toxicity and Cardiac Troponin
Allan Jaffe - Monitoring for Chemotherapy Toxicity and Cardiac Troponin
::2013/10/26::
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36
Troponin T Release After Rapid Pacing
Troponin T Release After Rapid Pacing
::2011/06/10::
Play Video
37
Troponin in HF, MI post-op, ROMICAT II
Troponin in HF, MI post-op, ROMICAT II
::2012/07/26::
Play Video
38
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/10/05::
Play Video
39
hm_Positive Troponin or BNP with LVH Increases Risk of CV Death
hm_Positive Troponin or BNP with LVH Increases Risk of CV Death
::2012/12/10::
Play Video
40
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
::2011/10/24::
Play Video
41
Troponin and MI 7
Troponin and MI 7
::2013/04/24::
Play Video
42
Introducing Bio Focus Co., Ltd
Introducing Bio Focus Co., Ltd
::2013/06/24::
Play Video
43
Singulex High-Definition Troponin Testing Part 2 - Sgx HD cTnI Test
Singulex High-Definition Troponin Testing Part 2 - Sgx HD cTnI Test
::2011/10/24::
Play Video
44
Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
::2013/02/14::
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45
Jesse Cedarbaum - Selective activators of fast skeletal muscle troponin
Jesse Cedarbaum - Selective activators of fast skeletal muscle troponin
::2012/10/23::
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46
troponin-C Пикотехнологическая модель белка тропонин-Ц
troponin-C Пикотехнологическая модель белка тропонин-Ц
::2014/01/15::
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47
My Formaldehyde Heart
My Formaldehyde Heart
::2011/10/02::
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48
troponin show
troponin show
::2014/02/14::
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49
The test that tells doctors a patient is having a heart attack
The test that tells doctors a patient is having a heart attack
::2012/01/05::
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50
Vista Therapeutics NanoBioSensor Introduction and Demo using PSA and Troponin NanoCards.MP4
Vista Therapeutics NanoBioSensor Introduction and Demo using PSA and Troponin NanoCards.MP4
::2012/01/15::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Troponin

Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

The tissue specific subtypes are:

  • Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042)
  • Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043)
  • Cardiac troponin I, TNNI3 (19q13.4, 191044)

cTnI[edit]

Human troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. The theoretical pI of cTnI is 9.87. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein – one dephospho, two monophospho and one bisphospho – can coexist in the cell. Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. According to the latest findings significant part of cTnI released into the patient’s blood stream is phosphorylated.[1] For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the “golden marker” of last decades – Creatin Kinase, as well as myoglobin and lactate dehydrogenase isoenzymes.

See also[edit]

External links[edit]

References[edit]

  1. ^ Labugger R, Organ L, Collier C, Atar D, Van Eyk JE (2000). "Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction". Circulation. 102 (11): 1221–1226. 


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