Play Video
1
Troponin I Serum/Whole Blood Rapid Test (Cassette)
Troponin I Serum/Whole Blood Rapid Test (Cassette)
::2013/09/19::
Play Video
2
Troponin 1: Cardiac Regulatory Protein
Troponin 1: Cardiac Regulatory Protein
::2010/07/30::
Play Video
3
Heart Attack Blood Test: Troponin
Heart Attack Blood Test: Troponin
::2014/01/22::
Play Video
4
Troponin and MI 1
Troponin and MI 1
::2013/04/24::
Play Video
5
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/02/15::
Play Video
6
Video Clip bioNexia Troponin I
Video Clip bioNexia Troponin I
::2012/08/18::
Play Video
7
ZBx Cardiac Troponin I Rapid Test
ZBx Cardiac Troponin I Rapid Test
::2012/11/22::
Play Video
8
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
::2011/10/14::
Play Video
9
Clinical use of Cardiac Troponin T
Clinical use of Cardiac Troponin T
::2013/03/18::
Play Video
10
Coding Elevated Troponin
Coding Elevated Troponin
::2013/06/11::
Play Video
11
Troponin i
Troponin i
::2014/06/29::
Play Video
12
Troponin I ELISA kit
Troponin I ELISA kit
::2013/06/20::
Play Video
13
Troponin I xét nghiệm 2
Troponin I xét nghiệm 2
::2014/06/29::
Play Video
14
Troponin I xét nghiệm
Troponin I xét nghiệm
::2014/06/29::
Play Video
15
Troponin I Domino
Troponin I Domino
::2012/08/07::
Play Video
16
Troponin Test
Troponin Test
::2012/02/03::
Play Video
17
Don
Don't blame it on the troponin
::2011/06/15::
Play Video
18
High sensitivity troponin T and AMI with Dr. Martin Holzmann
High sensitivity troponin T and AMI with Dr. Martin Holzmann
::2014/04/03::
Play Video
19
Meritas - Your Best Decision at Point of Care
Meritas - Your Best Decision at Point of Care
::2013/11/28::
Play Video
20
Dr. Allan Jaffe Discusses hs-Troponin at ACC.14
Dr. Allan Jaffe Discusses hs-Troponin at ACC.14
::2014/04/04::
Play Video
21
troponin.mp4
troponin.mp4
::2011/10/17::
Play Video
22
High-Sensitivity Troponin as a Biomarker: A PLATO Substudy
High-Sensitivity Troponin as a Biomarker: A PLATO Substudy
::2012/12/17::
Play Video
23
Justin Harris "Troponin" lower lat rows
Justin Harris "Troponin" lower lat rows
::2014/07/10::
Play Video
24
What is Troponin ?
What is Troponin ?
::2014/04/26::
Play Video
25
Troponin after Non-cardiac Surgery Predicts Bad Outcome
Troponin after Non-cardiac Surgery Predicts Bad Outcome
::2012/07/03::
Play Video
26
Allan Jaffe - Monitoring for Chemotherapy Toxicity and Cardiac Troponin
Allan Jaffe - Monitoring for Chemotherapy Toxicity and Cardiac Troponin
::2013/10/26::
Play Video
27
Troponin and MI 3
Troponin and MI 3
::2013/04/24::
Play Video
28
Initial Troponin & Early Changes Differentiate Chest Pain Pts
Initial Troponin & Early Changes Differentiate Chest Pain Pts
::2013/09/27::
Play Video
29
Justin Harris "Troponin" pulldowns
Justin Harris "Troponin" pulldowns
::2014/07/02::
Play Video
30
Troponin
Troponin
::2013/05/02::
Play Video
31
How to Pronounce Troponin
How to Pronounce Troponin
::2013/11/21::
Play Video
32
Hs-Troponin T, Silent Cerebral Ischemia and Complications in Afib
Hs-Troponin T, Silent Cerebral Ischemia and Complications in Afib
::2013/07/11::
Play Video
33
Health Talk - Troponin Test in Diagnosing Heart Attack
Health Talk - Troponin Test in Diagnosing Heart Attack
::2014/07/06::
Play Video
34
hm_Positive Troponin or BNP with LVH Increases Risk of CV Death
hm_Positive Troponin or BNP with LVH Increases Risk of CV Death
::2012/12/10::
Play Video
35
Troponin
Troponin
::2013/03/30::
Play Video
36
Justin Harris "Troponin" press downs
Justin Harris "Troponin" press downs
::2014/07/13::
Play Video
37
How a muscle contraction is signalled - Animation
How a muscle contraction is signalled - Animation
::2009/02/04::
Play Video
38
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/10/05::
Play Video
39
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
::2012/01/31::
Play Video
40
Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
::2013/02/14::
Play Video
41
Troponin T Release After Rapid Pacing
Troponin T Release After Rapid Pacing
::2011/06/10::
Play Video
42
troponin-C Пикотехнологическая модель белка тропонин-Ц
troponin-C Пикотехнологическая модель белка тропонин-Ц
::2014/01/15::
Play Video
43
Myosin is Thick, Actin is Thin
Myosin is Thick, Actin is Thin
::2012/02/16::
Play Video
44
Troponin and MI 7
Troponin and MI 7
::2013/04/24::
Play Video
45
Troponin and MI 5
Troponin and MI 5
::2013/04/24::
Play Video
46
Tropomyosin and troponin and their role in regulating muscle contraction Swahili
Tropomyosin and troponin and their role in regulating muscle contraction Swahili
::2013/01/04::
Play Video
47
Кардио тест.avi
Кардио тест.avi
::2011/07/11::
Play Video
48
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
::2011/10/24::
Play Video
49
Jesse Cedarbaum - Selective activators of fast skeletal muscle troponin
Jesse Cedarbaum - Selective activators of fast skeletal muscle troponin
::2012/10/23::
Play Video
50
Justin Harris "Troponin" Squats
Justin Harris "Troponin" Squats
::2014/07/17::
NEXT >>
RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
Jump to: navigation, search
Troponin

Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it, myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

The tissue specific subtypes are:

  • Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042)
  • Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043)
  • Cardiac troponin I, TNNI3 (19q13.4, 191044)

cTnI[edit]

Human troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. The theoretical pI of cTnI is 9.87. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein – one dephospho, two monophospho and one bisphospho – can coexist in the cell. Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. According to the latest findings significant part of cTnI released into the patient’s blood stream is phosphorylated.[1] For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the “golden marker” of last decades – Creatin Kinase, as well as myoglobin and lactate dehydrogenase isoenzymes.

See also[edit]

External links[edit]

References[edit]

  1. ^ Labugger R, Organ L, Collier C, Atar D, Van Eyk JE (2000). "Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction". Circulation. 102 (11): 1221–1226. 


Wikipedia content is licensed under the GFDL License
Powered by YouTube
LEGAL
  • Mashpedia © 2014