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1
Troponin 1: Cardiac Regulatory Protein
Troponin 1: Cardiac Regulatory Protein
::2010/07/30::
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2
Heart Attack Blood Test: Troponin
Heart Attack Blood Test: Troponin
::2014/01/21::
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3
Troponin I Serum/Whole Blood Rapid Test (Cassette)
Troponin I Serum/Whole Blood Rapid Test (Cassette)
::2013/09/19::
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4
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/02/15::
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5
Troponin and MI 1
Troponin and MI 1
::2013/04/24::
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6
Clinical use of Cardiac Troponin T
Clinical use of Cardiac Troponin T
::2013/03/18::
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7
Video Clip bioNexia Troponin I
Video Clip bioNexia Troponin I
::2012/08/18::
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8
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade...
::2011/10/14::
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9
Troponin Test
Troponin Test
::2012/02/03::
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10
Coding Elevated Troponin
Coding Elevated Troponin
::2013/06/11::
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11
ZBx Cardiac Troponin I Rapid Test
ZBx Cardiac Troponin I Rapid Test
::2012/11/22::
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12
Troponin i
Troponin i
::2014/06/29::
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13
Troponin I ELISA kit
Troponin I ELISA kit
::2013/06/20::
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14
Troponin I xét nghiệm
Troponin I xét nghiệm
::2014/06/29::
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15
Troponin I xét nghiệm 2
Troponin I xét nghiệm 2
::2014/06/29::
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16
Troponin I Domino
Troponin I Domino
::2012/08/07::
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17
Don
Don't blame it on the troponin
::2011/06/15::
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18
Dr. Allan Jaffe Discusses hs-Troponin at ACC.14
Dr. Allan Jaffe Discusses hs-Troponin at ACC.14
::2014/04/04::
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19
High sensitivity troponin T and AMI with Dr. Martin Holzmann
High sensitivity troponin T and AMI with Dr. Martin Holzmann
::2014/04/03::
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20
Meritas - Your Best Decision at Point of Care
Meritas - Your Best Decision at Point of Care
::2013/11/28::
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21
What is Troponin ?
What is Troponin ?
::2014/04/25::
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22
Justin Harris "Troponin" lower lat rows
Justin Harris "Troponin" lower lat rows
::2014/07/10::
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23
troponin.mp4
troponin.mp4
::2011/10/16::
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24
Troponin after Non-cardiac Surgery Predicts Bad Outcome
Troponin after Non-cardiac Surgery Predicts Bad Outcome
::2012/07/03::
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25
ทบทวนวิธีการตรวจ Troponin T
ทบทวนวิธีการตรวจ Troponin T
::2013/10/09::
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26
Justin Harris "Troponin" pulldowns
Justin Harris "Troponin" pulldowns
::2014/07/02::
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27
High-Sensitivity Troponin as a Biomarker: A PLATO Substudy
High-Sensitivity Troponin as a Biomarker: A PLATO Substudy
::2012/12/17::
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28
Health Talk - Troponin Test in Diagnosing Heart Attack
Health Talk - Troponin Test in Diagnosing Heart Attack
::2014/07/06::
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29
Troponin and MI 3
Troponin and MI 3
::2013/04/24::
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30
Troponin
Troponin
::2013/05/02::
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31
Initial Troponin & Early Changes Differentiate Chest Pain Pts
Initial Troponin & Early Changes Differentiate Chest Pain Pts
::2013/09/27::
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32
Justin Harris "Troponin" Kroc log lunges
Justin Harris "Troponin" Kroc log lunges
::2014/08/02::
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33
Justin Harris "Troponin" Squats
Justin Harris "Troponin" Squats
::2014/07/17::
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34
Hs-Troponin T, Silent Cerebral Ischemia and Complications in Afib
Hs-Troponin T, Silent Cerebral Ischemia and Complications in Afib
::2013/07/11::
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35
Justin Harris "Troponin" dumbell presses
Justin Harris "Troponin" dumbell presses
::2014/07/01::
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36
Allan Jaffe - Monitoring for Chemotherapy Toxicity and Cardiac Troponin
Allan Jaffe - Monitoring for Chemotherapy Toxicity and Cardiac Troponin
::2013/10/26::
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37
Justin Harris "Troponin" press downs
Justin Harris "Troponin" press downs
::2014/07/13::
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38
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
Dr. Karl Theakston - High Sensitivity Troponins: A change in practice
::2012/01/30::
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39
Justin Harris " Troponin " hammer strength
Justin Harris " Troponin " hammer strength
::2014/07/01::
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40
How a muscle contraction is signalled - Animation
How a muscle contraction is signalled - Animation
::2009/02/04::
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41
SENSATIVE TEST FOR HEART ATTACK , TROPONIN , HEALTH EDUCATION , ICSP , URDU / HINDI .
SENSATIVE TEST FOR HEART ATTACK , TROPONIN , HEALTH EDUCATION , ICSP , URDU / HINDI .
::2012/01/14::
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42
Justin Harris "Troponin" red bands bench
Justin Harris "Troponin" red bands bench
::2014/07/28::
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43
Troponin
Troponin
::2013/03/30::
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44
Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
Using Polarizable Force Fields and Accelerated Molecular Dynamics to Investigate Troponin C
::2013/02/14::
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45
Troponin T Release After Rapid Pacing
Troponin T Release After Rapid Pacing
::2011/06/10::
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46
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
Singulex High-Definition Troponin Testing Part 1 - Benefits and Opportunity
::2011/10/24::
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47
troponin-C Пикотехнологическая модель белка тропонин-Ц
troponin-C Пикотехнологическая модель белка тропонин-Ц
::2014/01/15::
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48
hm_Positive Troponin or BNP with LVH Increases Risk of CV Death
hm_Positive Troponin or BNP with LVH Increases Risk of CV Death
::2012/12/10::
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49
Tropomyosin and troponin and their role in regulating muscle contraction
Tropomyosin and troponin and their role in regulating muscle contraction
::2010/10/05::
Play Video
50
Troponin and MI 7
Troponin and MI 7
::2013/04/24::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Troponin

Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it, myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which lead to dislocation of troponin I and finally tropomyosin leaves the binding site for myosin on actin leading to contraction of muscle. The letter I is given due to its inhibitory character.

The tissue specific subtypes are:

  • Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042)
  • Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043)
  • Cardiac troponin I, TNNI3 (19q13.4, 191044)

cTnI[edit]

Human troponin I, often denoted as cTnI, is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. The theoretical pI of cTnI is 9.87. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein – one dephospho, two monophospho and one bisphospho – can coexist in the cell. Phosphorylation of cTnI changes the conformation of the protein and modifies its interaction with other troponins as well as the interaction with anti-TnI antibodies. According to the latest findings significant part of cTnI released into the patient’s blood stream is phosphorylated.[1] For more than 15 years cTnI has been known as a reliable marker of cardiac muscle tissue injury. It is considered to be more sensitive and significantly more specific in diagnosis of the myocardial infarction than the “golden marker” of last decades – Creatin Kinase, as well as myoglobin and lactate dehydrogenase isoenzymes.

See also[edit]

External links[edit]

References[edit]

  1. ^ Labugger R, Organ L, Collier C, Atar D, Van Eyk JE (2000). "Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction". Circulation. 102 (11): 1221–1226. 


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