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Type-V collagen is a form of fibrillar[1] collagen associated with classical Ehlers-Danlos syndrome. It is found within the dermal/epidermal junction, placental tissues, as well as in association with tissues containing Type-I collagen.[2]

Autoimmunity against type V collagen is associated with lung transplant failure.[3][4][5]



  1. ^ Wenstrup RJ, Florer JB, Brunskill EW, Bell SM, Chervoneva I, Birk DE (2004). "Type V collagen controls the initiation of collagen fibril assembly". J. Biol. Chem. 279 (51): 53331–7. doi:10.1074/jbc.M409622200. PMID 15383546. 
  2. ^ Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K, Malfait F, Wenstrup R, De Paepe A (1993). "Ehlers-Danlos Syndrome, Classic Type". PMID 20301422. 
  3. ^ "Studies on Collagen". Retrieved 13 July 2016. 
  4. ^ Haque, MA; Mizobuchi, T; Yasufuku, K; Fujisawa, T; Brutkiewicz, RR; Zheng, Y; Woods, K; Smith, GN; Cummings, OW; Heidler, KM; Blum, JS; Wilkes, DS (Aug 1, 2002). "Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection". Journal of Immunology. 169 (3): 1542–9. doi:10.4049/jimmunol.169.3.1542. PMID 12133982. 
  5. ^ Iwata T, Philipovskiy A, Fisher AJ, Presson RG, Chiyo M, Lee J, Mickler E, Smith GN, Petrache I, Brand DB, Burlingham WJ, Gopalakrishnan B, Greenspan DS, Christie JD, Wilkes DS (Oct 15, 2008). "Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction". Journal of Immunology. 181 (8): 5738–47. doi:10.4049/jimmunol.181.8.5738. PMC 2997998Freely accessible. PMID 18832733. 

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