Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
Signal transduction chains [edit]
The signal transducing chains are often shared between different receptors within this receptor family.[1]
- The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
- The gp230 receptor common gamma chain (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
Examples [edit]
Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors
Interleukin receptors [edit]
Colony stimulating factor receptors [edit]
Hormone receptor/neuropeptide receptor [edit]
References [edit]
- ^ Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders. ISBN 0-7216-0008-5.
- ^ He YW, Adkins B, Furse RK, Malek TR (1995). "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor". J. Immunol. 154 (4): 1596–605. PMID 7530740.
- ^ Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors". J. Biol. Chem. 273 (2): 1192–9. doi:10.1074/jbc.273.2.1192. PMID 9422786.
External links [edit]
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Chemokine receptor
(GPCRs) |
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| TNF receptor |
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| JAK-STAT |
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| Ig superfamily |
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| IL-17 family |
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| S/T |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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| Ligand |
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| Cytokine receptor |
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| Janus kinase |
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| Adaptor proteins |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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