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1
Prof. Dame Kay Davies discusses utrophin research
Prof. Dame Kay Davies discusses utrophin research
::2011/08/09::
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2
2011 MDA Telethon Research - Utrophin
2011 MDA Telethon Research - Utrophin
::2011/09/03::
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OST - Trauma Center Under The Knife: Gangliated Utrophin Immuno Latency Toxin.
OST - Trauma Center Under The Knife: Gangliated Utrophin Immuno Latency Toxin.
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Trauma Center Under The Knife - HAAAX!!! Part 2
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[Top 100 Modern VGTunes] #063 - Trauma Center: Under the Knife - G.U.I.L.T.
::2010/05/20::
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[MMV] Christmas Must Be Something More
[MMV] Christmas Must Be Something More
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STory Mod ep 5: A New Threat
STory Mod ep 5: A New Threat
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2011 MDA Telethon Research - Thank You Researchers
2011 MDA Telethon Research - Thank You Researchers
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OST - Trauma Center Second Opinion: Second Opinion.
OST - Trauma Center Second Opinion: Second Opinion.
::2012/01/18::
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Trauma Center Under the Knife 2 -  Confronting the menace
Trauma Center Under the Knife 2 - Confronting the menace
::2008/10/10::
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Ridiculous (Video Promotion by Ricky Tsang)
Ridiculous (Video Promotion by Ricky Tsang)
::2011/08/09::
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(9) Emergency - Trauma Center Second Opinion OST
(9) Emergency - Trauma Center Second Opinion OST
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Neuromuscular Disease in the Genomic Era - Kenneth Fischbeck
Neuromuscular Disease in the Genomic Era - Kenneth Fischbeck
::2013/01/11::
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2011 MDA Telethon Profile - Jayson Torres
2011 MDA Telethon Profile - Jayson Torres
::2011/09/03::
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Muscular Dystrophy Campaign research
Muscular Dystrophy Campaign research
::2011/08/09::
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OST - Trauma Center Under The Knife 2: Success.
OST - Trauma Center Under The Knife 2: Success.
::2012/01/07::
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18
2011 MDA Telethon Profile Update - How is Kelly Mahoney Doing?
2011 MDA Telethon Profile Update - How is Kelly Mahoney Doing?
::2011/09/03::
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2006 MDA Telethon - Celine Dion performs "Summertime"
2006 MDA Telethon - Celine Dion performs "Summertime"
::2010/04/26::
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20
10/4 ED750 PM A
10/4 ED750 PM A
::2012/10/04::
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OST - Trauma Center Under The Knife 2: For a Better Tomorrow.
OST - Trauma Center Under The Knife 2: For a Better Tomorrow.
::2012/01/07::
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22
Dame Kay Davies - OUMNH 150th Anniversary Lectures
Dame Kay Davies - OUMNH 150th Anniversary Lectures
::2010/12/15::
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23
Thank you Bertie23
Thank you Bertie23
::2011/08/09::
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OST - Trauma Center Second Opinion: The Patient
OST - Trauma Center Second Opinion: The Patient's Life is in your hands!
::2012/01/18::
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OST - Trauma Center Under The Knife 2: Confronting the Menace.
OST - Trauma Center Under The Knife 2: Confronting the Menace.
::2012/01/07::
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TOP [130] Last Boss Ost #67 - Trauma Center Under the Knife 2 - Severing the Chains of Fate
TOP [130] Last Boss Ost #67 - Trauma Center Under the Knife 2 - Severing the Chains of Fate
::2012/07/31::
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OST TC New Blood - 34 Cardia
OST TC New Blood - 34 Cardia
::2010/04/26::
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Trauma Center Under the Knife 2 -  Operation Under Way
Trauma Center Under the Knife 2 - Operation Under Way
::2008/10/07::
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29
2011 MDA Telethon Research - Transitional Services
2011 MDA Telethon Research - Transitional Services
::2011/09/03::
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OST - Trauma Center Under The Knife: Let
OST - Trauma Center Under The Knife: Let's begin.
::2012/01/07::
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OST - Trauma Center Under The Knife 2: The Burden Of Failure.
OST - Trauma Center Under The Knife 2: The Burden Of Failure.
::2012/01/07::
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Matthew Morrison - 2013 MDA Telethon Promo
Matthew Morrison - 2013 MDA Telethon Promo
::2013/08/29::
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OST Trauma Center UTK 2 - 10 Unfaltering Hands
OST Trauma Center UTK 2 - 10 Unfaltering Hands
::2010/04/02::
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Let
Let's Play Trauma Team [40] Do villains deserve to die?
::2013/01/22::
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Let
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::2011/03/31::
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Trauma Center Under the Knife music - Main Theme (extended)
Trauma Center Under the Knife music - Main Theme (extended)
::2011/05/21::
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OST - Trauma Center Second Opinion Operation: Briefing.
OST - Trauma Center Second Opinion Operation: Briefing.
::2012/01/18::
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OST - Trauma Center Under The Knife 2: Briefing.
OST - Trauma Center Under The Knife 2: Briefing.
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Wii Playthrough: Trauma Team ~Patient Zero~ Part 9
Wii Playthrough: Trauma Team ~Patient Zero~ Part 9
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OST - Trauma Center Second Opinion: Bonus ~ Wii Intro.
OST - Trauma Center Second Opinion: Bonus ~ Wii Intro.
::2012/01/18::
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41
Trauma Center tribute
Trauma Center tribute
::2010/03/10::
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42
2011 MDA Telethon Research - SMA
2011 MDA Telethon Research - SMA
::2011/09/03::
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43
OST TC New Blood - 35 Cardia II
OST TC New Blood - 35 Cardia II
::2010/04/27::
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44
Steambot Chronicles Savory date part 1 Impress
Steambot Chronicles Savory date part 1 Impress
::2009/07/11::
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45
Trauma Center Under the Knife 2 - Briefing
Trauma Center Under the Knife 2 - Briefing
::2008/10/03::
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Trauma Center Under the Knife 2  2-3 (Part 1)
Trauma Center Under the Knife 2 2-3 (Part 1)
::2010/03/19::
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47
OST - Trauma Center Second Opinion: Vulnerability.
OST - Trauma Center Second Opinion: Vulnerability.
::2012/01/18::
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48
Trauma Team UOST: 38. Eureka Moment
Trauma Team UOST: 38. Eureka Moment
::2012/03/30::
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49
Trauma Center: Under the Knife 2 - Encroaching Shadows REMIX (Immature WIP)
Trauma Center: Under the Knife 2 - Encroaching Shadows REMIX (Immature WIP)
::2011/07/30::
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50
OST TC New Blood - 29 Miracle Surgery!
OST TC New Blood - 29 Miracle Surgery!
::2010/04/24::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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Utrophin

PDB rendering based on 1bhd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UTRN ; DMDL; DRP; DRP1
External IDs OMIM128240 MGI104631 HomoloGene21398 GeneCards: UTRN Gene
RNA expression pattern
PBB GE UTRN 213023 at tn.png
PBB GE UTRN 213022 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7402 22288
Ensembl ENSG00000152818 ENSMUSG00000019820
UniProt P46939 E9Q6R7
RefSeq (mRNA) NM_007124 NM_011682
RefSeq (protein) NP_009055 NP_035812
Location (UCSC) Chr 6:
144.61 – 145.17 Mb
Chr 10:
12.38 – 12.86 Mb
PubMed search [1] [2]

Utrophin is a protein that in humans is encoded by the UTRN gene.[1][2]

The protein encoded by this gene is a component of the cytoskeleton. Utrophin was found during research into Duchenne's muscular dystrophy. The name is a contraction for ubiquitous dystrophin. The 900 kb gene for utrophin is found on the long arm of human chromosome 6. Utrophin was discovered due to its homology with dystrophin. It was found by screening a peptide containing the C-terminal domain of dystrophin against cDNA libraries. The homology varies over its full length from less than 30% in regions of the central rod structural domain, to 85% (identity 73%) for the actin binding domain.

The tertiary structure of utrophin contains a C-terminus that consists of protein–protein interaction motifs that interact with dystroglycan, a central rod region consisting of a triple coiled-coil repeat, and an actin-binding N-terminus.

In normal muscle cells, utrophin is located at the neuromuscular synapse and myotendinous junctions. It is necessary for normal membrane maintenance, and for the clustering of the acetylcholine receptor. In adult humans, utrophin RNA is found ubiquitously, as the name implies, being abundant in the brain, kidney, liver, lung, muscle, spleen and stomach. In the human fetus during muscle differentiation, utrophin is found at the sarcolemma. It disappears when the fetus begins to express dystrophin.

Utrophin expression is dramatically increased in patients with Duchenne's muscular dystrophy (and female carriers), both in those muscle fibers lacking dystrophin and in rare, revertant fibers that express dystrophin.

No reports have yet associated mutation in the utrophin gene with disease, but it does not seem to play a critical role in development, since mice without utrophin develop normally.

References[edit]

  1. ^ Nguyen TM, Le TT, Blake DJ, Davies KE, Morris GE (Dec 1992). "Utrophin, the autosomal homologue of dystrophin, is widely-expressed and membrane-associated in cultured cell lines". FEBS Lett 313 (1): 19–22. doi:10.1016/0014-5793(92)81174-K. PMID 1426262. 
  2. ^ "Entrez Gene: UTRN utrophin". 

Further reading[edit]

See also[edit]

External links[edit]

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