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The Voice 2016 Blind Audition - Paxton Ingram: "Dancing on My Own"
The Voice 2016 Blind Audition - Paxton Ingram: "Dancing on My Own"
Published: 2016/03/01
Channel: The Voice
Goin threw things in life
Goin threw things in life
Published: 2013/03/16
Channel: Vernon Ingram
Vernons Aces - Paul Ingram
Vernons Aces - Paul Ingram
Published: 2017/04/01
Channel: Paul Ingram
Maggie Ingram " The Lord Will Make A Way"
Maggie Ingram " The Lord Will Make A Way"
Published: 2010/11/14
Channel: rtdigitalrecording
Bullets and Guns
Bullets and Guns
Published: 2013/12/12
Channel: Vernon Ingram
Ingram Wilcox wins Millionaire
Ingram Wilcox wins Millionaire
Published: 2011/07/22
Channel: RomeijnLand
And She Was Gone
And She Was Gone
Published: 2015/06/23
Channel: Various Artists - Topic
Conversation
Conversation
Published: 2015/06/23
Channel: Various Artists - Topic
Sports Science: Melvin Ingram
Sports Science: Melvin Ingram
Published: 2012/03/26
Channel: fernandomorquecho
Look For Me
Look For Me
Published: 2015/06/23
Channel: Various Artists - Topic
Gloves Off
Gloves Off
Published: 2015/06/23
Channel: Various Artists - Topic
Mark Ingram Bullies His Way in for the TD | Falcons vs. Saints | NFL
Mark Ingram Bullies His Way in for the TD | Falcons vs. Saints | NFL
Published: 2015/10/16
Channel: NFL
Jack Ingram
Jack Ingram's Acoustic Motel Spotlights Drew Kennedy on The Texas Music Scene
Published: 2014/04/28
Channel: The Texas Music Scene TV
Did I tell You
Did I tell You
Published: 2015/06/23
Channel: Various Artists - Topic
Remember
Remember
Published: 2015/06/23
Channel: Various Artists - Topic
Live Performance 1
Live Performance 1
Published: 2010/10/04
Channel: captainTWEETY
To Be
To Be
Published: 2015/06/23
Channel: Various Artists - Topic
[The Alle]
[The Alle]
Published: 2015/06/23
Channel: Various Artists - Topic
Saints RB Mark Ingram Training.mov
Saints RB Mark Ingram Training.mov
Published: 2011/05/27
Channel: rob3237
My Bernice
My Bernice
Published: 2015/06/23
Channel: Various Artists - Topic
Live Performance 6
Live Performance 6
Published: 2010/10/05
Channel: captainTWEETY
Byhalia
Byhalia
Published: 2015/06/23
Channel: Various Artists - Topic
Into The Next
Into The Next
Published: 2015/06/23
Channel: Various Artists - Topic
Alabama RB 40-Yard Dash Simulcam: Derrick Henry vs. Mark Ingram vs. T.J. Yeldon | 2016 NFL Combine
Alabama RB 40-Yard Dash Simulcam: Derrick Henry vs. Mark Ingram vs. T.J. Yeldon | 2016 NFL Combine
Published: 2016/02/26
Channel: NFL
Mark Ingram Sports Science Breakdown
Mark Ingram Sports Science Breakdown
Published: 2010/03/28
Channel: JoshuaKiwi
Live Performance 4
Live Performance 4
Published: 2010/10/05
Channel: captainTWEETY
Looking for my shoes
Looking for my shoes
Published: 2015/06/23
Channel: Various Artists - Topic
Short Flight
Short Flight
Published: 2015/06/23
Channel: Various Artists - Topic
Mia Pataca
Mia Pataca
Published: 2015/06/23
Channel: Various Artists - Topic
Five
Five
Published: 2015/06/23
Channel: Various Artists - Topic
Captain Tweety
Captain Tweety
Published: 2015/06/23
Channel: Various Artists - Topic
Live Performance 2
Live Performance 2
Published: 2010/10/04
Channel: captainTWEETY
Live Performance 3
Live Performance 3
Published: 2010/10/05
Channel: captainTWEETY
West Rogers Park
West Rogers Park
Published: 2015/06/23
Channel: Various Artists - Topic
The Zone
The Zone
Published: 2015/06/23
Channel: Various Artists - Topic
Something To Make You Smile
Something To Make You Smile
Published: 2015/06/23
Channel: Various Artists - Topic
Live Performance 5
Live Performance 5
Published: 2010/10/05
Channel: captainTWEETY
Brandon Ingram Full Highlights ACC Tourn vs NC State 2nd Rd (3-9-16) 22 Pts 7 Rebs 4 Asts, SO GOOD!
Brandon Ingram Full Highlights ACC Tourn vs NC State 2nd Rd (3-9-16) 22 Pts 7 Rebs 4 Asts, SO GOOD!
Published: 2016/03/10
Channel: ShowTyme Collegiate BasketBall Media
Ingeli
Ingeli
Published: 2015/06/23
Channel: Various Artists - Topic
MIT Admissions Video (1997)
MIT Admissions Video (1997)
Published: 2016/06/14
Channel: forever90s
Glass Ships
Glass Ships
Published: 2015/06/23
Channel: Various Artists - Topic
Worm Hole
Worm Hole
Published: 2015/06/23
Channel: Various Artists - Topic
Love Seasons
Love Seasons
Published: 2015/06/23
Channel: Various Artists - Topic
My Daughter Camille
My Daughter Camille
Published: 2015/06/23
Channel: Various Artists - Topic
One Woman Man [1978] - Jimmy Martin
One Woman Man [1978] - Jimmy Martin
Published: 2017/06/09
Channel: Take's Bluegrass Album Channel
Final Exit
Final Exit
Published: 2015/06/23
Channel: Various Artists - Topic
Roger Ingram: Roger
Roger Ingram: Roger's Story
Published: 2015/04/16
Channel: jwpepper1876
What Is The Relationship Between Genes And Proteins?
What Is The Relationship Between Genes And Proteins?
Published: 2017/09/11
Channel: Silly Question
What Is The Relationship Between Genes And Proteins?
What Is The Relationship Between Genes And Proteins?
Published: 2017/09/03
Channel: Last Question
Sydney Brenner - The gene protein problem (81/236)
Sydney Brenner - The gene protein problem (81/236)
Published: 2017/07/05
Channel: Web of Stories - Life Stories of Remarkable People
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WIKIPEDIA ARTICLE

From Wikipedia, the free encyclopedia
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Vernon Martin Ingram
Born (1924-05-19)19 May 1924
Breslau, Germany
Died 17 August 2006(2006-08-17) (aged 82)
Boston, Massachusetts
Residence Germany, United Kingdom, United States
Nationality German
Alma mater University of London
Spouse(s) Elizabeth Ingram
Children Peter, Jennifer
Awards William Allan Award (1967)
Scientific career
Fields Biologist
Institutions MIT
Doctoral advisor Fred Barrow

Vernon Martin Ingram, PhD, FRS (19 May 1924 – 17 August 2006) born Werner Adolf Martin Immerwahr, was a German American professor of biology at the Massachusetts Institute of Technology.

Biography[edit]

Ingram was born in Breslau, Lower Silesia. When he was 14, he and his family left Nazi Germany because of their opposition to Nazism (being Jewish) and settled in England. He then Anglicised his name to Vernon Ingram.

During the Second World War, Ingram worked at a chemical factory producing drugs for the war effort and at night studied at Birkbeck College at the University of London. He received a bachelor's degree in chemistry in 1945 and a PhD in organic chemistry in 1949.

After receiving his doctorate, Ingram worked at postdoctoral appointments at the Rockefeller Institute and Yale University. At Rockefeller, he worked with Moses Kunitz on crystallising proteins. While at Yale, he studied peptide chemistry with Joseph Fruton. In 1952, Ingram returned to England and started working at the Cavendish Laboratory at the University of Cambridge, studying protein chemistry.

In 1956, Ingram, John A. Hunt, and Antony O. W. Stretton determined that the change in the haemoglobin molecule in sickle cell disease and trait was the substitution of the glutamic acid in position 6 of the β-chain of the normal protein by valine. Ingram used electrophoresis and chromatography to show that the amino acid sequence of normal human and sickle cell anaemia haemoglobins differed due to a single substituted amino acid residue. Much of this work was done with the support of Max Perutz and Francis Crick. Ingram won the William Allan Award from the American Society of Human Genetics in 1967.

This was the first time a researcher demonstrated that a single amino acid exchange in a protein can cause a disease or disorder. As a result, Vernon Ingram is sometimes referred to as "The father of Molecular Medicine." [1]

Ingram joined the MIT faculty in 1958, intending to stay for only one year. He found that he enjoyed it there so much that he stayed on. While at MIT, Ingram collaborated with Paul Marks of Columbia University on haemoglobin research. He was also interested in embryonic haemoglobin and how it differed from that of adults.

By the 1980s, Ingram became interested in neuroscience and especially Alzheimer's Disease. His interest was sparked by the work his second wife, Elizabeth (Beth), was doing with mentally retarded people in the Boston area. She had heard that Down syndrome was a disease of the neurofilaments; this turned out not to be the cause, but it was noted that people with Down syndrome did develop Alzheimer's Disease by the time they were 40.

After retirement, Ingram continued his research, maintaining a small laboratory at MIT. He and his wife, Beth, were housemasters of Ashdown House at MIT for 16 years. Asteroid 6285 Ingram is named in their honour. Ingram was Director of the Experimental Study Group, an alternative undergraduate education community at MIT, from 1989 to 1999. [2] He was elected to the National Academy of Sciences in 2002. [3]

Ingram died in Boston, Massachusetts, on 17 August 2006 of injuries stemming from a fall.

See also[edit]

Selected publications[edit]

  • Ingram, V.M. (1956). "A Specific Chemical Difference between Globins of Normal and Sickle-cell Anemia Hemoglobins". Nature. 178 (4537): 792–794. PMID 13369537. doi:10.1038/178792a0. 
  • Ingram,, V.M. (1957). "Gene Mutations in Human Hemoglobin: The Chemical Difference between Normal and Sickle Hemoglobin". Nature. 180 (4581): 326–328. PMID 13464827. doi:10.1038/180326a0. 
  • Hunt, J.A.; V.M. Ingram (1958). "Abnormal Human Haemoglobins. II. The Chymotryptic Digestion of the Trypsin-resistant Core of Haemoglobins A and S". Biochimica et Biophysica Acta. 28 (3): 46–549. PMID 13560405. doi:10.1016/0006-3002(58)90517-1. 
  • Blanchard, B.J.; A. Chen; C. Kelly; K. Stafford; B. Stockwell; V.M. Ingram (2004). "Novel Compounds eliminate the Neurotoxicity of the Alzheimer Aβ Peptide". Abstr. Massachusetts Alzheimer's Disease Research Center, Annual meeting. 
  • Ingram, V.M.; B.J. Blanchard; A. Chen; C. Kelly; K. Stafford; B. Stockwell (2004). "Blocking the Initial Molecular Mechanism of Alzheimer's Disease". Abstr. International Congress on Alzheimer's Disease, Philadelphia. 
  • Ingram, V.M. (2004). "The Role of Alzheimer Aβ Peptides in Ion Transport across Cell Membranes, in Subcellular Biochemistry: Alzheimer’s Disease". In eds. Harris, R.; Fahrenholz, F. Cellular and Molecular Aspects of Amyloid. London: Kluwer Academic/Plenum Publishers. 
  • Colby, D.W.; P. Garg; G. Chao; J. Webster; A. Messer; V.M. Ingram; K.D. Wittrup (17 September 2004). "Development of a Human Variable Light Chain Domain Intracellular Antibody against Huntingtin via Yeast Surface Display". J. Mol. Biol. 342 (3): 901–12. PMID 15342245. doi:10.1016/j.jmb.2004.07.054. 
  • Webster, J.M.; D.W. Colby; V.M. Ingram; K.D. Wittrup; A. Messer (November 2004). "Enhanced anti-Huntington's Disease Intrabodies". Abstract Soc. Neurosci. 

Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule Barbara J. Blanchard, Albert Chen, Leslie M. Rozeboom, Kate A. Stafford, Peter Weigele, and Vernon M. Ingram PNAS 2004 101: 14326-14332

See also[edit]

References[edit]

  1. ^ "2002 National Academy Fellows". Genome Biology. 2 May 2002. Retrieved 25 October 2006. 
  2. ^ Darren J. Clarke (17 July 2002). "Surprise! High-flying Tribute for Ingrams". MIT News Office. Retrieved 25 October 2006. 
  3. ^ "Three Faculty Named to NAS". MIT News Office. 15 May 2002. Retrieved 25 October 2006. 

External links[edit]

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