Play Video
1
Ingram Marshall - Fog Tropes II (1982)
Ingram Marshall - Fog Tropes II (1982)
::2009/10/22::
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2
Dam shr b ad
Dam shr b ad
::2013/02/11::
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3
Sports Science:  Vernon Davis
Sports Science: Vernon Davis
::2009/12/02::
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4
Wolfedance 2007 Jack Ingram Mustang
Wolfedance 2007 Jack Ingram Mustang
::2007/07/07::
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5
Sports Science: Melvin Ingram
Sports Science: Melvin Ingram
::2012/03/26::
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6
Jack Ingram "Biloxi" Showcase Performance
Jack Ingram "Biloxi" Showcase Performance
::2012/05/15::
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7
Darren Sproles & Mark Ingram Combo - Road To The Super Bowl - Week 5 - Madden 12 - Online Franchise
Darren Sproles & Mark Ingram Combo - Road To The Super Bowl - Week 5 - Madden 12 - Online Franchise
::2011/11/10::
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8
Land For Sale Mount Vernon WA Real Estate $74950
Land For Sale Mount Vernon WA Real Estate $74950
::2014/09/23::
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9
WABC 77 New York - Dan Ingram - April 10, 1968 (1/2)
WABC 77 New York - Dan Ingram - April 10, 1968 (1/2)
::2012/06/17::
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10
Manufactured Homes For Sale Mount Vernon WA Real Estate $37500 2-Bdrms 1.75-Baths
Manufactured Homes For Sale Mount Vernon WA Real Estate $37500 2-Bdrms 1.75-Baths
::2014/08/21::
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11
Mark Ingram Sports Science Breakdown
Mark Ingram Sports Science Breakdown
::2010/03/28::
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12
Mark Ingram at Alabama pro day 2011
Mark Ingram at Alabama pro day 2011
::2011/03/09::
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13
One Life to Live June 16 1978 CD 92 Part 2
One Life to Live June 16 1978 CD 92 Part 2
::2014/06/16::
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14
One Life to Live June 13 , 14 1978 CD 91(Out of 106) Part 1
One Life to Live June 13 , 14 1978 CD 91(Out of 106) Part 1
::2014/06/14::
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15
Marquel Ingram Highlights
Marquel Ingram Highlights
::2012/10/06::
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16
One Life to Live  June 7, 8 1978 CD 89 Bonus 5th Daytime Emmy Awards
One Life to Live June 7, 8 1978 CD 89 Bonus 5th Daytime Emmy Awards
::2014/06/06::
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17
Lon Ingram - Chasing Waterfalls: Real world Front End Optimization
Lon Ingram - Chasing Waterfalls: Real world Front End Optimization
::2014/09/19::
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18
Earl Thomas vs Mark Ingram - BOOM!
Earl Thomas vs Mark Ingram - BOOM!
::2013/12/04::
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19
MOH recipient Robert R. Ingram
MOH recipient Robert R. Ingram
::2009/04/07::
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20
Peter Green - Little Dreamer ( Full Album ) 1980
Peter Green - Little Dreamer ( Full Album ) 1980
::2014/03/10::
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21
Cry Me A River TB Feature Aug 2 2013
Cry Me A River TB Feature Aug 2 2013
::2014/06/25::
Play Video
22
Derrick Ingram #4  WR/DB Jefferson High School Class of 2014 Jr. Season Highlights 6
Derrick Ingram #4 WR/DB Jefferson High School Class of 2014 Jr. Season Highlights 6'1 195 lbs
::2013/06/20::
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23
The National Flag League Video #2 Melvin Ingram Drew Brees
The National Flag League Video #2 Melvin Ingram Drew Brees
::2012/10/08::
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24
Ingram Park and the Civil Rights Movement
Ingram Park and the Civil Rights Movement
::2010/03/03::
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25
Quincy Ingram Highlights 2010-2011
Quincy Ingram Highlights 2010-2011
::2011/05/18::
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26
Making Pigs Fly: Functional Reactive Programming with jQuery, Flight and Bacon.js - Lon Ingram
Making Pigs Fly: Functional Reactive Programming with jQuery, Flight and Bacon.js - Lon Ingram
::2014/05/30::
Play Video
27
Diana Ingram plays Millionaire - Part 2
Diana Ingram plays Millionaire - Part 2
::2010/08/21::
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28
Jadeveon Clowney Selected #1 In NFL Draft
Jadeveon Clowney Selected #1 In NFL Draft
::2014/05/08::
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29
Longtime Vernon Downs announcer calls last horse race
Longtime Vernon Downs announcer calls last horse race
::2014/04/11::
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30
A FLG Maurepas upload - The Ingram Kingdom aka Ingram Family - Put Your Troubles Behind - Soul Funk
A FLG Maurepas upload - The Ingram Kingdom aka Ingram Family - Put Your Troubles Behind - Soul Funk
::2014/05/12::
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31
One Life to Live June 9 1978 CD 90 Part 2 Audio
One Life to Live June 9 1978 CD 90 Part 2 Audio
::2014/06/09::
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32
Charla Corn "Done" Mount Vernon Session
Charla Corn "Done" Mount Vernon Session
::2013/01/15::
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33
Ollie On Freret Commercial -- Mark Ingram/Juggie pt 1
Ollie On Freret Commercial -- Mark Ingram/Juggie pt 1
::2011/06/25::
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34
Danielle Ingram (Revelation Song)
Danielle Ingram (Revelation Song)
::2013/11/02::
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35
Vernon Davis Crying
Vernon Davis Crying
::2012/01/16::
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36
Bishop Ingram - Boston Hartford NEAC First Episcopal District - 3 points
Bishop Ingram - Boston Hartford NEAC First Episcopal District - 3 points
::2013/10/26::
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37
D.J. Logic with Vernon Reid at the Bowery Ballroom, N.Y.C, 2001
D.J. Logic with Vernon Reid at the Bowery Ballroom, N.Y.C, 2001
::2011/05/27::
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38
OYOSports Fantasy Football - Draft Day
OYOSports Fantasy Football - Draft Day
::2014/08/26::
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39
One Life to Live March 3 1978 CD 60 Part 1 Audio
One Life to Live March 3 1978 CD 60 Part 1 Audio
::2014/03/04::
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40
Sports Science: Vernon Davis
Sports Science: Vernon Davis
::2012/01/04::
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41
104.7 FISH ATLANTA, Michelle Vernon, Celebrate Freedom, Mighty to Save
104.7 FISH ATLANTA, Michelle Vernon, Celebrate Freedom, Mighty to Save
::2010/08/02::
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42
New Orleans Saints 23 vs San Francisco 49ers 20 - Week 11 NFL Analysis
New Orleans Saints 23 vs San Francisco 49ers 20 - Week 11 NFL Analysis
::2013/11/18::
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43
10 18 13 Pope John Vernon Football
10 18 13 Pope John Vernon Football
::2013/10/22::
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44
"Jupiter - Bring of Jollity" performed by the Barbara Ingram School for the Arts Symphony Orchestra
"Jupiter - Bring of Jollity" performed by the Barbara Ingram School for the Arts Symphony Orchestra
::2014/06/11::
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45
Saints 2011 Draft Pick Mark Ingram, Gets Emotional Message from Jailed dad
Saints 2011 Draft Pick Mark Ingram, Gets Emotional Message from Jailed dad
::2011/04/30::
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46
One Life to Live May 31, June 1 1978 CD 87 Part 1 Audio
One Life to Live May 31, June 1 1978 CD 87 Part 1 Audio
::2014/05/31::
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47
Chip Ingram - Building Below the Water Line, part 1. [James 3:13-18]
Chip Ingram - Building Below the Water Line, part 1. [James 3:13-18]
::2012/08/18::
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48
Experiencing God
Experiencing God's Dream for Your Marriage
::2010/07/07::
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Johnny Ingram-Your Precious Love
Johnny Ingram-Your Precious Love
::2013/04/25::
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James Ingram & Michael McDonald -Yah Mo B There (HDAudioPlus HiDef Analog Remaster)
James Ingram & Michael McDonald -Yah Mo B There (HDAudioPlus HiDef Analog Remaster)
::2014/09/27::
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From Wikipedia, the free encyclopedia
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Vernon Martin Ingram
Born (1924-05-19)19 May 1924
Breslau, Germany
Died 17 August 2006(2006-08-17) (aged 82)
Boston, Massachusetts
Residence Germany, United Kingdom, United States
Nationality German
Fields Biologist
Institutions MIT
Alma mater University of London
Doctoral advisor Fred Barrow
Notable awards William Allan Award (1967)
Spouse Elizabeth Ingram
Children Peter, Jennifer

Vernon Martin Ingram, Ph.D., FRS (19 May 1924 — 17 August 2006) was a German American professor of biology at the Massachusetts Institute of Technology.

Biography[edit]

Ingram was born in Breslau, Lower Silesia. When he was 14, he and his family left Nazi Germany because of their opposition to Nazism and settled in England.

During the Second World War, Ingram worked at a chemical factory producing drugs for the war effort and at night studied at Birkbeck College at the University of London. He received a bachelor's degree in chemistry in 1945 and a PhD in organic chemistry in 1949.

After receiving his doctorate, Ingram worked at postdoctoral appointments at the Rockefeller Institute and Yale University. At Rockefeller, he worked with Moses Kunitz on crystallizing proteins. While at Yale, he studied peptide chemistry with Joseph Fruton. In 1952, Ingram returned to England and started working at the Cavendish Laboratory at the University of Cambridge, studying protein chemistry.

In 1956, Ingram, John A. Hunt, and Antony O. W. Stretton determined that the change in the hemoglobin molecule in sickle cell disease and trait was the substitution of the glutamic acid in position 6 of the β-chain of the normal protein by valine. Ingram used electrophoresis and chromatography to show that the amino acid sequence of normal human and sickle cell anemia hemoglobins differed due to a single substituted amino acid residue. Much of this work was done with the support of Max Perutz and Francis Crick. Ingram won the William Allan Award from the American Society of Human Genetics in 1967.

This was the first time a researcher demonstrated that a single amino acid exchange in a protein can cause a disease or disorder. As a result, Vernon Ingram is sometimes referred to as "The father of Molecular Medicine." [1]

Ingram joined the MIT faculty in 1958, intending to stay for only one year. He found that he enjoyed it there so much that he stayed on. While at MIT, Ingram collaborated with Paul Marks of Columbia University on hemoglobin research. He was also interested in embryonic hemoglobin and how it differed from that of adults.

By the 1980s, Ingram became interested in neuroscience and especially Alzheimer's Disease. His interest was sparked by the work his second wife, Elizabeth (Beth), was doing with mentally retarded people in the Boston area. She had heard that Down syndrome was a disease of the neurofilaments; this turned out not to be the cause, but it was noted that people with Down syndrome did develop Alzheimer's Disease by the time they were 40.

After retirement, Ingram continued his research, maintaining a small laboratory at MIT. He and his wife, Beth, were housemasters of Ashdown House at MIT for 16 years. Asteroid 6285 Ingram is named in their honor. [2] He was elected to the National Academy of Sciences in 2002. [3]

Ingram died in Boston, Massachusetts, on August 17, 2006 of injuries stemming from a fall.

See also[edit]

Selected publications[edit]

  • Ingram, V.M. (1956). "A Specific Chemical Difference between Globins of Normal and Sickle-cell Anemia Hemoglobins". Nature 178 (4537): 792–794. doi:10.1038/178792a0. PMID 13369537. 
  • Ingram,, V.M. (1957). "Gene Mutations in Human Hemoglobin: The Chemical Difference between Normal and Sickle Hemoglobin". Nature 180 (4581): 326–328. doi:10.1038/180326a0. PMID 13464827. 
  • Hunt, J.A.; V.M. Ingram (1958). "Abnormal Human Haemoglobins. II. The Chymotryptic Digestion of the Trypsin-resistant Core of Haemoglobins A and S". Biochimica et Biophysica Acta 28 (3): 46–549. doi:10.1016/0006-3002(58)90517-1. PMID 13560405. 
  • Blanchard, B.J.; A. Chen, C. Kelly, K. Stafford, B. Stockwell & V.M. Ingram (2004). "Novel Compounds eliminate the Neurotoxicity of the Alzheimer Aβ Peptide". Abstr. Massachusetts Alzheimer’s Disease Research Center, Annual meeting. 
  • Ingram, V.M.; B.J. Blanchard, A. Chen, C. Kelly, K. Stafford & B. Stockwell (2004). "Blocking the Initial Molecular Mechanism of Alzheimer’s Disease". Abstr. International Congress on Alzheimer’s Disease, Philadelphia. 
  • Ingram, V.M. (2004). "The Role of Alzheimer Aβ Peptides in Ion Transport across Cell Membranes, in Subcellular Biochemistry: Alzheimer’s Disease". In eds. Harris, R., Fahrenholz, F. Cellular and Molecular Aspects of Amyloid. London: Kluwer Academic/Plenum Publishers. 
  • Colby, D.W.; P. Garg, G. Chao, J. Webster, A. Messer, V.M. Ingram and K.D. Wittrup (17 September 2004). "Development of a Human Variable Light Chain Domain Intracellular Antibody against Huntingtin via Yeast Surface Display". J. Mol. Biol. 342 (3): 901–12. doi:10.1016/j.jmb.2004.07.054. PMID 15342245. 
  • Webster, J.M.; D.W. Colby, V.M. Ingram, K.D. Wittrup and A. Messer (November 2004). "Enhanced anti-Huntington's Disease Intrabodies". Abstract Soc. Neurosci. 

Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule Barbara J. Blanchard, Albert Chen, Leslie M. Rozeboom, Kate A. Stafford, Peter Weigele, and Vernon M. Ingram PNAS 2004 101: 14326-14332

See also[edit]

References[edit]

  1. ^ "2002 National Academy Fellows". Genome Biology. 2002-05-02. Retrieved 2006-10-25. 
  2. ^ Darren J. Clarke (2002-07-17). "Surprise! High-flying Tribute for Ingrams". MIT News Office. Retrieved 2006-10-25. 
  3. ^ "Three Faculty Named to NAS". MIT News Office. 2002-05-15. Retrieved 2006-10-25. 

External links[edit]

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