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::2013/02/12::
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::2010/10/04::
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Bullets and Guns
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::2013/12/12::
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Land For Sale Mount Vernon WA Real Estate $79500 Mount Vernon WA
Land For Sale Mount Vernon WA Real Estate $79500 Mount Vernon WA
::2014/02/27::
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Mortal Kombat 9 - Babalities Part 3
Mortal Kombat 9 - Babalities Part 3
::2011/04/26::
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Ingram Marshall - Fog Tropes II (1982)
Ingram Marshall - Fog Tropes II (1982)
::2009/10/23::
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Goin threw things in life
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::2013/03/16::
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Dora Kills Swiper The FOx
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::2011/04/07::
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How to get Paladin Class In Adventure Quest Worlds
How to get Paladin Class In Adventure Quest Worlds
::2011/06/15::
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Legend of Zelda: Twilight Princess last hidden skill
Legend of Zelda: Twilight Princess last hidden skill
::2007/05/06::
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196 Shoreline Drive New London, NC 28127  Presented by Ramona Ingram
196 Shoreline Drive New London, NC 28127 Presented by Ramona Ingram
::2014/03/08::
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Justin Vernon - Satisfied Mind
Justin Vernon - Satisfied Mind
::2014/01/27::
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Kam Chancellor decleats Vernon Davis yet again
Kam Chancellor decleats Vernon Davis yet again
::2014/01/21::
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2013 Dance Ambassador Tony Ingram
2013 Dance Ambassador Tony Ingram
::2013/04/24::
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Sports Science:  Vernon Davis
Sports Science: Vernon Davis
::2009/12/02::
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Marquel Ingram Highlights
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::2012/10/06::
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Longtime Vernon Downs announcer calls last horse race
Longtime Vernon Downs announcer calls last horse race
::2014/04/12::
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Wolfedance 2007 Jack Ingram Mustang
Wolfedance 2007 Jack Ingram Mustang
::2007/07/08::
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Mike Raita of ABC 33/40 Has Lost His Mind.
Mike Raita of ABC 33/40 Has Lost His Mind.
::2013/08/16::
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SHR 18th Feb 720p
SHR 18th Feb 720p
::2014/02/19::
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1950 Blackface Performance: Vernon & Ryan
1950 Blackface Performance: Vernon & Ryan
::2007/10/01::
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1372 Lake Shore Drive New London, NC 28127  Presented by Ramona Ingram
1372 Lake Shore Drive New London, NC 28127 Presented by Ramona Ingram
::2014/02/20::
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Bishop Gregory Ingram - 3 points
Bishop Gregory Ingram - 3 points
::2013/10/19::
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Chip Ingram - Building Below the Water Line, part 1. [James 3:13-18]
Chip Ingram - Building Below the Water Line, part 1. [James 3:13-18]
::2012/08/18::
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HVAC Vernon Hills (847) 281-5999 Heating Cooling Service
HVAC Vernon Hills (847) 281-5999 Heating Cooling Service
::2012/12/29::
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128 Badin Lake Circle New London, NC 28127  Presented by Ramona Ingram
128 Badin Lake Circle New London, NC 28127 Presented by Ramona Ingram
::2014/03/23::
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Chump Change- Shark Tank Submission Video- Helena Ingram
Chump Change- Shark Tank Submission Video- Helena Ingram
::2014/02/27::
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B@sH@R
B@sH@R
::2013/07/24::
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Pete Vernon plays Millionaire - Part 2
Pete Vernon plays Millionaire - Part 2
::2010/08/24::
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Richard Turner Bio Part 1.mov
Richard Turner Bio Part 1.mov
::2014/04/19::
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Peter Green - Little Dreamer ( Full Album ) 1980
Peter Green - Little Dreamer ( Full Album ) 1980
::2014/03/10::
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922 Pinehaven Drive New London, NC 28127  Presented by Ramona Ingram
922 Pinehaven Drive New London, NC 28127 Presented by Ramona Ingram
::2014/03/24::
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2011 BMW 135i Burlington WA Mt Vernon, WA #K12612
2011 BMW 135i Burlington WA Mt Vernon, WA #K12612
::2014/04/10::
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Sports Science: Mark Ingram
Sports Science: Mark Ingram
::2012/01/08::
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39
One Life to Live March 6, 7 1978 CD 60 Part 3 Audio
One Life to Live March 6, 7 1978 CD 60 Part 3 Audio
::2014/03/05::
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40
Parking at the Mall on Ellen show
Parking at the Mall on Ellen show
::2014/04/12::
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41
Vernon Moore "Draw to You"
Vernon Moore "Draw to You"
::2011/08/30::
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42
Sermon:  Jesus Cares (Dr. Beulah Ingram)
Sermon: Jesus Cares (Dr. Beulah Ingram)
::2013/05/28::
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City of Vernon
City of Vernon
::2013/01/16::
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Vernon Open Floor Plan Home for Sale - 145 Hany Ln 06066
Vernon Open Floor Plan Home for Sale - 145 Hany Ln 06066
::2014/03/24::
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Kanye West Feat Justin Vernon - Lost In The World (Live) (Legendado)
Kanye West Feat Justin Vernon - Lost In The World (Live) (Legendado)
::2013/09/28::
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One Life to Live February  20, 21 1978 CD 56 Part 1 Audio
One Life to Live February 20, 21 1978 CD 56 Part 1 Audio
::2014/02/19::
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Quincy Ingram Highlights 2010-2011
Quincy Ingram Highlights 2010-2011
::2011/05/19::
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48
KaTanya Ingram - Ohio Idol - Round 2
KaTanya Ingram - Ohio Idol - Round 2
::2012/06/16::
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49
Brandon Lynch Heavy Weight 2/25/2014 NY Golden Gloves Mt. Vernon Boxing Club
Brandon Lynch Heavy Weight 2/25/2014 NY Golden Gloves Mt. Vernon Boxing Club
::2014/02/27::
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ingram drive
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::2012/05/07::
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From Wikipedia, the free encyclopedia
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Vernon Martin Ingram
Born (1924-05-19)19 May 1924
Breslau, Germany
Died 17 August 2006(2006-08-17) (aged 82)
Boston, Massachusetts
Residence Germany, United Kingdom, United States
Nationality German
Fields Biologist
Institutions MIT
Alma mater University of London
Doctoral advisor Fred Barrow
Spouse Elizabeth Ingram
Children Peter, Jennifer

Vernon Martin Ingram, Ph.D., FRS (19 May 1924 — 17 August 2006) was a German American professor of biology at the Massachusetts Institute of Technology.

Biography[edit]

Ingram was born in Breslau, Lower Silesia. When he was 14, he and his family left Nazi Germany because of their opposition to Nazism and settled in England.

During the Second World War, Ingram worked at a chemical factory producing drugs for the war effort and at night studied at Birkbeck College at the University of London. He received a bachelor's degree in chemistry in 1945 and a PhD in organic chemistry in 1949.

After receiving his doctorate, Ingram worked at postdoctoral appointments at the Rockefeller Institute and Yale University. At Rockefeller, he worked with Moses Kunitz on crystallizing proteins. While at Yale, he studied peptide chemistry with Joseph Fruton. In 1952, Ingram returned to England and started working at the Cavendish Laboratory at the University of Cambridge, studying protein chemistry.

In 1956, Ingram, John A. Hunt, and Antony O. W. Stretton determined that the change in the hemoglobin molecule in sickle cell disease and trait was the substitution of the glutamic acid in position 6 of the β-chain of the normal protein by valine. Ingram used electrophoresis and chromatography to show that the amino acids of normal human and sickle cell anemia hemoglobins differed due to a single mutated gene. Much of this work was done with the support of Max Perutz and Francis Crick. Ingram won the William Allan Award from the American Society of Human Genetics in 1967.

This was the first time a researcher demonstrated that a single amino acid exchange in a protein can cause a disease or disorder. As a result, Vernon Ingram is sometimes referred to as "The father of Molecular Medicine." [1]

Ingram joined the MIT faculty in 1958, intending to stay for only one year. He found that he enjoyed it there so much that he stayed on. While at MIT, Ingram collaborated with Paul Marks of Columbia University on hemoglobin research. He was also interested in embryonic hemoglobin and how it differed from that of adults.

By the 1980s, Ingram became interested in neuroscience and especially Alzheimer's Disease. His interest was sparked by the work his second wife, Elizabeth (Beth), was doing with mentally retarded people in the Boston area. She had heard that Down syndrome was a disease of the neurofilaments; this turned out not to be the cause, but it was noted that people with Down syndrome did develop Alzheimer's Disease by the time they were 40.

After retirement, Ingram continued his research, maintaining a small laboratory at MIT. He and his wife, Beth, were housemasters of Ashdown House at MIT for 16 years. Asteroid 6285 Ingram is named in their honor. [2] He was elected to the National Academy of Sciences in 2002. [3]

Ingram died in Boston, Massachusetts, on August 17, 2006 of injuries stemming from a fall.

See also[edit]

Selected publications[edit]

  • Ingram, V.M. (1956). "A Specific Chemical Difference between Globins of Normal and Sickle-cell Anemia Hemoglobins". Nature 178 (4537): 792–794. doi:10.1038/178792a0. PMID 13369537. 
  • Ingram,, V.M. (1957). "Gene Mutations in Human Hemoglobin: The Chemical Difference between Normal and Sickle Hemoglobin". Nature 180 (4581): 326–328. doi:10.1038/180326a0. PMID 13464827. 
  • Hunt, J.A.; V.M. Ingram (1958). "Abnormal Human Haemoglobins. II. The Chymotryptic Digestion of the Trypsin-resistant Core of Haemoglobins A and S". Biochimica et Biophysica Acta 28 (3): 46–549. doi:10.1016/0006-3002(58)90517-1. PMID 13560405. 
  • Blanchard, B.J.; A. Chen, C. Kelly, K. Stafford, B. Stockwell & V.M. Ingram (2004). "Novel Compounds eliminate the Neurotoxicity of the Alzheimer Aβ Peptide". Abstr. Massachusetts Alzheimer’s Disease Research Center, Annual meeting. 
  • Ingram, V.M.; B.J. Blanchard, A. Chen, C. Kelly, K. Stafford & B. Stockwell (2004). "Blocking the Initial Molecular Mechanism of Alzheimer’s Disease". Abstr. International Congress on Alzheimer’s Disease, Philadelphia. 
  • Ingram, V.M. (2004). "The Role of Alzheimer Aβ Peptides in Ion Transport across Cell Membranes, in Subcellular Biochemistry: Alzheimer’s Disease". In eds. Harris, R., Fahrenholz, F. Cellular and Molecular Aspects of Amyloid. London: Kluwer Academic/Plenum Publishers. 
  • Colby, D.W.; P. Garg, G. Chao, J. Webster, A. Messer, V.M. Ingram and K.D. Wittrup (17 September 2004). "Development of a Human Variable Light Chain Domain Intracellular Antibody against Huntingtin via Yeast Surface Display". J. Mol. Biol. 342 (3): 901–12. doi:10.1016/j.jmb.2004.07.054. PMID 15342245. 
  • Webster, J.M.; D.W. Colby, V.M. Ingram, K.D. Wittrup and A. Messer (November 2004). "Enhanced anti-Huntington's Disease Intrabodies". Abstract Soc. Neurosci. 

Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule Barbara J. Blanchard, Albert Chen, Leslie M. Rozeboom, Kate A. Stafford, Peter Weigele, and Vernon M. Ingram PNAS 2004 101: 14326-14332

See also[edit]

References[edit]

  1. ^ "2002 National Academy Fellows". Genome Biology. 2002-05-02. Retrieved 2006-10-25. 
  2. ^ Darren J. Clarke (2002-07-17). "Surprise! High-flying Tribute for Ingrams". MIT News Office. Retrieved 2006-10-25. 
  3. ^ "Three Faculty Named to NAS". MIT News Office. 2002-05-15. Retrieved 2006-10-25. 

External links[edit]

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