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One Life to Live June 16 1978 CD 92 Part 2
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KD Kids 2014: The Greatest Book On Earth!
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One Life to Live December 28 1977 CD 40 Part 4 Audio
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One Life to Live  June 7, 8 1978 CD 89 Bonus 5th Daytime Emmy Awards
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New Breed R&B With Added Popcorn
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"Jupiter - Bring of Jollity" performed by the Barbara Ingram School for the Arts Symphony Orchestra
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One Life to Live May 5, 8, 9 1978 CD 78 Audio
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Cry Me A River TB Feature Aug 2 2013
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One Life to Live June 13 , 14 1978 CD 91(Out of 106) Part 1
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New Orleans Saints 23 vs San Francisco 49ers 20 - Week 11 NFL Analysis
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One Life to Live March 3 1978 CD 60 Part 1 Audio
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"Down To The River" (1977) Maggie Ingram & The Ingramettes
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Jack Ingram "Biloxi" Showcase Performance
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#5 Vernon Grier WR/KR Mallard Creek HS Full Season 2014
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OYOSports Fantasy Football - Draft Day
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One Life to Live May 30, 31 1978 CD 86 Part 1 Audio
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WABC 77 New York - Dan Ingram - April 10, 1968 (1/2)
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Sports Science: Melvin Ingram
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Mark Ingram Sports Science
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Sports Science:  Vernon Davis
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One Life to Live August 14 1978 CD 96 Part 4
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Kinston High School Brandon Ingram MONSTER DUNK
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Hall Johnson Choir -- Little Black Sheep (Church Song)
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One Life to Live May 24, 25 1978 CD 84 Part 2 Audio
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Sport Science: Vernon Davis goes through a tight end gauntlet
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J Vernon Mcgee - Why God Gave Palestine to Israel
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#32 Tharon Ingram LB Mallard Creek HS Full Season 2014
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One Life to Live April 27, 28, May 1 1978 CD 75 Audio
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Conference Championship- Vernon Davis & Frank Gore- Road to the Super Bowl- Giants 49ers Madden 13
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Duke Ellington In The Background -- Night Club Scene, Shine, Buck and Bubbles
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OWC2013 Keagan
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Al B. Sure - Touch You 1990
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From Wikipedia, the free encyclopedia
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Vernon Martin Ingram
Born (1924-05-19)19 May 1924
Breslau, Germany
Died 17 August 2006(2006-08-17) (aged 82)
Boston, Massachusetts
Residence Germany, United Kingdom, United States
Nationality German
Fields Biologist
Institutions MIT
Alma mater University of London
Doctoral advisor Fred Barrow
Notable awards William Allan Award (1967)
Spouse Elizabeth Ingram
Children Peter, Jennifer

Vernon Martin Ingram, Ph.D., FRS (19 May 1924 — 17 August 2006) was a German American professor of biology at the Massachusetts Institute of Technology.

Biography[edit]

Ingram was born in Breslau, Lower Silesia. When he was 14, he and his family left Nazi Germany because of their opposition to Nazism and settled in England.

During the Second World War, Ingram worked at a chemical factory producing drugs for the war effort and at night studied at Birkbeck College at the University of London. He received a bachelor's degree in chemistry in 1945 and a PhD in organic chemistry in 1949.

After receiving his doctorate, Ingram worked at postdoctoral appointments at the Rockefeller Institute and Yale University. At Rockefeller, he worked with Moses Kunitz on crystallizing proteins. While at Yale, he studied peptide chemistry with Joseph Fruton. In 1952, Ingram returned to England and started working at the Cavendish Laboratory at the University of Cambridge, studying protein chemistry.

In 1956, Ingram, John A. Hunt, and Antony O. W. Stretton determined that the change in the hemoglobin molecule in sickle cell disease and trait was the substitution of the glutamic acid in position 6 of the β-chain of the normal protein by valine. Ingram used electrophoresis and chromatography to show that the amino acid sequence of normal human and sickle cell anemia hemoglobins differed due to a single substituted amino acid residue. Much of this work was done with the support of Max Perutz and Francis Crick. Ingram won the William Allan Award from the American Society of Human Genetics in 1967.

This was the first time a researcher demonstrated that a single amino acid exchange in a protein can cause a disease or disorder. As a result, Vernon Ingram is sometimes referred to as "The father of Molecular Medicine." [1]

Ingram joined the MIT faculty in 1958, intending to stay for only one year. He found that he enjoyed it there so much that he stayed on. While at MIT, Ingram collaborated with Paul Marks of Columbia University on hemoglobin research. He was also interested in embryonic hemoglobin and how it differed from that of adults.

By the 1980s, Ingram became interested in neuroscience and especially Alzheimer's Disease. His interest was sparked by the work his second wife, Elizabeth (Beth), was doing with mentally retarded people in the Boston area. She had heard that Down syndrome was a disease of the neurofilaments; this turned out not to be the cause, but it was noted that people with Down syndrome did develop Alzheimer's Disease by the time they were 40.

After retirement, Ingram continued his research, maintaining a small laboratory at MIT. He and his wife, Beth, were housemasters of Ashdown House at MIT for 16 years. Asteroid 6285 Ingram is named in their honor. [2] He was elected to the National Academy of Sciences in 2002. [3]

Ingram died in Boston, Massachusetts, on August 17, 2006 of injuries stemming from a fall.

See also[edit]

Selected publications[edit]

  • Ingram, V.M. (1956). "A Specific Chemical Difference between Globins of Normal and Sickle-cell Anemia Hemoglobins". Nature 178 (4537): 792–794. doi:10.1038/178792a0. PMID 13369537. 
  • Ingram,, V.M. (1957). "Gene Mutations in Human Hemoglobin: The Chemical Difference between Normal and Sickle Hemoglobin". Nature 180 (4581): 326–328. doi:10.1038/180326a0. PMID 13464827. 
  • Hunt, J.A.; V.M. Ingram (1958). "Abnormal Human Haemoglobins. II. The Chymotryptic Digestion of the Trypsin-resistant Core of Haemoglobins A and S". Biochimica et Biophysica Acta 28 (3): 46–549. doi:10.1016/0006-3002(58)90517-1. PMID 13560405. 
  • Blanchard, B.J.; A. Chen, C. Kelly, K. Stafford, B. Stockwell & V.M. Ingram (2004). "Novel Compounds eliminate the Neurotoxicity of the Alzheimer Aβ Peptide". Abstr. Massachusetts Alzheimer’s Disease Research Center, Annual meeting. 
  • Ingram, V.M.; B.J. Blanchard, A. Chen, C. Kelly, K. Stafford & B. Stockwell (2004). "Blocking the Initial Molecular Mechanism of Alzheimer’s Disease". Abstr. International Congress on Alzheimer’s Disease, Philadelphia. 
  • Ingram, V.M. (2004). "The Role of Alzheimer Aβ Peptides in Ion Transport across Cell Membranes, in Subcellular Biochemistry: Alzheimer’s Disease". In eds. Harris, R., Fahrenholz, F. Cellular and Molecular Aspects of Amyloid. London: Kluwer Academic/Plenum Publishers. 
  • Colby, D.W.; P. Garg, G. Chao, J. Webster, A. Messer, V.M. Ingram and K.D. Wittrup (17 September 2004). "Development of a Human Variable Light Chain Domain Intracellular Antibody against Huntingtin via Yeast Surface Display". J. Mol. Biol. 342 (3): 901–12. doi:10.1016/j.jmb.2004.07.054. PMID 15342245. 
  • Webster, J.M.; D.W. Colby, V.M. Ingram, K.D. Wittrup and A. Messer (November 2004). "Enhanced anti-Huntington's Disease Intrabodies". Abstract Soc. Neurosci. 

Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule Barbara J. Blanchard, Albert Chen, Leslie M. Rozeboom, Kate A. Stafford, Peter Weigele, and Vernon M. Ingram PNAS 2004 101: 14326-14332

See also[edit]

References[edit]

  1. ^ "2002 National Academy Fellows". Genome Biology. 2002-05-02. Retrieved 2006-10-25. 
  2. ^ Darren J. Clarke (2002-07-17). "Surprise! High-flying Tribute for Ingrams". MIT News Office. Retrieved 2006-10-25. 
  3. ^ "Three Faculty Named to NAS". MIT News Office. 2002-05-15. Retrieved 2006-10-25. 

External links[edit]

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