Play Video
1
CURE FOR CANCER - Dr. William Coley
CURE FOR CANCER - Dr. William Coley's Fluid
::2012/03/01::
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2
2012 William B. Coley Award for Distinguished Research in Basic Immunology
2012 William B. Coley Award for Distinguished Research in Basic Immunology
::2013/01/02::
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3
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
::2013/10/23::
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4
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
::2011/10/30::
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5
Meet the new Michael Johnson - William Coley
Meet the new Michael Johnson - William Coley
::2012/06/03::
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6
3TC- William Coley halfpipe session
3TC- William Coley halfpipe session
::2011/10/23::
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7
3TC- William Coley shuvit rock-to-fakie
3TC- William Coley shuvit rock-to-fakie
::2011/10/22::
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8
3TC- William Coley kickflip rock-to-fakie 180
3TC- William Coley kickflip rock-to-fakie 180
::2011/10/22::
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9
CRI Awards - Coley Award in Tumor Immunology
CRI Awards - Coley Award in Tumor Immunology
::2013/05/17::
Play Video
10
Ch 1 of 12 "Coley
Ch 1 of 12 "Coley's Toxins" - DVD Bonus Clip from "Second Opinion: Laetrile At Sloan-Kettering"
::2014/02/19::
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11
Daryl Coley-He
Daryl Coley-He's Preparing Me (Extended Version)
::2011/09/14::
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12
William and Coley laughing and sitting up
William and Coley laughing and sitting up
::2013/02/10::
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13
2013 Cancer Research Institute Awards Dinner highlights
2013 Cancer Research Institute Awards Dinner highlights
::2013/11/26::
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14
Willy Wise vs Derrell Coley
Willy Wise vs Derrell Coley
::2011/04/13::
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15
DERRELL COLEY - DOMINIQUE WADE IS BETTER THAN WHO????
DERRELL COLEY - DOMINIQUE WADE IS BETTER THAN WHO????
::2014/07/01::
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16
Immunotherapy for Cancer - Coley Fluid - Gerson
Immunotherapy for Cancer - Coley Fluid - Gerson's diet
::2009/03/22::
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17
Daryl Coley - Stand
Daryl Coley - Stand
::2010/01/13::
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18
DARYL COLEY - II CHRONICLES
DARYL COLEY - II CHRONICLES
::2013/10/22::
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19
Cancer Research Institute 60th Anniversary Awards Dinner: Welcome by John Fitzgibbons
Cancer Research Institute 60th Anniversary Awards Dinner: Welcome by John Fitzgibbons
::2013/10/23::
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20
Full Gospel Baptist Fellowship Mass Choir feat. Daryl Coley - The Giver
Full Gospel Baptist Fellowship Mass Choir feat. Daryl Coley - The Giver
::2013/12/08::
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21
dare devil boys-free running dos
dare devil boys-free running dos
::2012/08/19::
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22
DARYL COLEY...JESUS SAVES
DARYL COLEY...JESUS SAVES
::2011/07/28::
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23
Daryl Coley Jesus never fails
Daryl Coley Jesus never fails
::2012/03/21::
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24
Young Coley - Ben (produced by David Duke)
Young Coley - Ben (produced by David Duke)
::2012/01/05::
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25
I Will Bless Your Name - Daryl Coley
I Will Bless Your Name - Daryl Coley
::2011/04/12::
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26
Daryl Coley- In the arms of Jesus
Daryl Coley- In the arms of Jesus
::2011/06/07::
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27
Daryl Coley
Daryl Coley
::2008/04/27::
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28
Gunfitting with Ian Coley
Gunfitting with Ian Coley
::2011/10/27::
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29
Daryl Coley "I Can
Daryl Coley "I Can't Tell It All"
::2010/03/03::
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30
Haiti 361
Haiti 361
::2013/01/14::
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31
He
He's Preparing Me.avi
::2011/06/25::
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32
Finally I (D) Daryl Coley Performance Track
Finally I (D) Daryl Coley Performance Track
::2010/11/10::
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33
DERRELL COLEY - CMON THOMAS "TOP DOG" WILLIAMS... #coleysaidit
DERRELL COLEY - CMON THOMAS "TOP DOG" WILLIAMS... #coleysaidit
::2014/08/06::
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34
Never Let You Down- Daryl Coley
Never Let You Down- Daryl Coley
::2013/02/02::
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35
Coley
Coley's Toxins
::2012/07/26::
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36
Mike Francis SRP
Mike Francis SRP
::2010/10/27::
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37
Mildred A. Atkins-Coley Home Going Service HD
Mildred A. Atkins-Coley Home Going Service HD
::2014/05/13::
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38
Daryl Coley- Comforter has come
Daryl Coley- Comforter has come
::2012/12/11::
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39
DERRELL COLEY - LAMONT PETERSON vs DANNY GARCIA?? #coleysaidit
DERRELL COLEY - LAMONT PETERSON vs DANNY GARCIA?? #coleysaidit
::2014/08/12::
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40
Lindell Coley - Send The Fire
Lindell Coley - Send The Fire
::2009/03/14::
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41
Coley and Jarvo enjoy Park visit
Coley and Jarvo enjoy Park visit
::2014/04/02::
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42
"Psalm 27" (1989) Daryl Coley & Bruce Parham
"Psalm 27" (1989) Daryl Coley & Bruce Parham
::2013/01/19::
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43
Instrument of praise, Eddie Baltrip ft Daryl Coley
Instrument of praise, Eddie Baltrip ft Daryl Coley
::2012/02/20::
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44
DERRELL COLEY - Talks LAMONT PETERSON
DERRELL COLEY - Talks LAMONT PETERSON
::2014/04/04::
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45
DERRELL COLEY - MESSAGE FOR SUGAR RAY LEONARD
DERRELL COLEY - MESSAGE FOR SUGAR RAY LEONARD
::2014/04/09::
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46
Sweet Communion-Daryl Coley
Sweet Communion-Daryl Coley
::2009/11/14::
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47
DERRELL COLEY - STORY BEHIND THE OSCAR DE LA HOYA FIGHT
DERRELL COLEY - STORY BEHIND THE OSCAR DE LA HOYA FIGHT
::2014/04/02::
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48
Edwin Hawkins & The M&ASMC (feat. Daryl L. Coley)  "He
Edwin Hawkins & The M&ASMC (feat. Daryl L. Coley) "He'll Understand"
::2013/01/28::
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49
DERRELL COLEY - HIT RESET!!! #mondaymotivation
DERRELL COLEY - HIT RESET!!! #mondaymotivation
::2014/04/28::
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DERRELL COLEY - MIKE TYSON TRUE STORY!!!
DERRELL COLEY - MIKE TYSON TRUE STORY!!!
::2014/05/09::
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RESULTS [51 .. 101]
From Wikipedia, the free encyclopedia
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William Bradley Coley
William Coley 1892.jpg
Born (1862-01-12)January 12, 1862
Westfield, Connecticut
Died April 16, 1936(1936-04-16) (aged 74)
Parents Horace Bradley Coley
Clarina B. Wakeman

William Bradley Coley (January 12, 1862 – April 16, 1936) was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy.[1] He developed a treatment based on provoking an immune response to bacteria. In 1968 a protein related to his work was identified and called tumor necrosis factor-alpha.[2]

Biography[edit]

He was born on January 12, 1862 in Westfield, Connecticut to Horace Bradley Coley and Clarina B. Wakeman.

He began his career as a bone surgeon at New York Cancer Hospital (which later became part of the Memorial Sloan-Kettering Cancer Center); however, he became more interested in cancer treatment when one of his early patients, Elizabeth Dashiell,[3] died from bone cancer. While going through hospital records, Coley found a sarcoma case study of one patient named Fred Stein, whose tumor disappeared following a high fever from erysipelas infection, now known as Streptococcus pyogenes.[4] This sparked Coley's interest and drove him to find what few examples of similar cancer treatment had been previously recorded. He discovered that other medical pioneers including Robert Koch, Louis Pasteur, and Emil von Behring, had recorded observations of erysipelas infection coinciding with cancer regression.[citation needed]

Work on cancer and immune response[edit]

Main article: Coley's toxins

Coley developed the theory that post-surgical infections had helped patients to recover better from their cancer by provoking an immune response.[1] He began to experiment by deliberating causing this phenomenon, injecting bacteria directly into people being treated – but because this had the adverse effect of causing infection he then switched to using dead bacteria.[1] Coley published the results of his work as a case series, making it difficult to interpret them with confidence. According to the American Cancer Society, "more research would be needed to determine what benefit, if any, this therapy might have for people with cancer".[1] Cancer Research UK say that "available scientific evidence does not currently support claims that Coley's toxins can treat or prevent cancer".[5] People with cancer who take Coley's toxins alongside conventional cancer treatments, or who use it as a substitute for those treatments, risk seriously harming their health.[5]

Radiation therapy vs. Coley vaccine[edit]

By 1901, the development of x-rays as a cancer treatment showed great promise. In particular, the therapy resulted in immediate tumor destruction and pain relief. Although Coley claimed successful treatment of hundreds of patients, the absence of proven benefit or reproducibility led to broader emphasis on surgery and on the newly developing field of radiation therapy. This decision was borne out by the eventual successful treatment of millions of people worldwide with radiation therapy.[citation needed]

Coley arranged for a wealthy friend to provide funds to purchase two x-ray machines for his use. However, after several years of experience, Coley came to the conclusion that the effect of that primitive x-ray therapy in the untrained hands of experimenters was localized, temporary and not curative. The scientific majority disagreed, most notably his contemporary James Ewing. His contemporary critics cited the dangerous and unpredictable effects, predominantly the fever caused by the bacteria, that the vaccine had upon individuals weakened by cancer. Furthermore the vaccine had to be made to a patient's exact needs, making it more labour-intensive, time-consuming and expensive.[citation needed]

Coley died on April 16, 1936.[6]

Legacy[edit]

In 2005, drug makers including Pfizer and Sanofi-Aventis had a renewed interest in modern versions of Coley's Toxins;[7] Pfizer has acquired the Coley Pharmaceutical Group, set up in 1997[8]

The historical results of Coley vaccine therapy are difficult to compare with modern results. Coley's studies were not well controlled and factors such as length of treatment and fever level were not adequately documented. Many of his patients had also received radiation and sometimes surgery. According to the analyses of Coley Nauts and Starnes, treatment success correlated with length of therapy and the fevers induced by the toxins.[9]

See also[edit]

References[edit]

  1. ^ a b c d "Coley Toxins". American Cancer Society. 1 November 2008. Retrieved April 2014. 
  2. ^ Terlikowski SJ (2001). "Tumour necrosis factor and cancer treatment: a historical review and perspectives". Rocz. Akad. Med. Bialymst. 46: 5–18. PMID 11780579. 
  3. ^ Groopman, Jerome (2008). How Doctors Think. ISBN 978-0-547-05364-6. 
  4. ^ Coley WB (1893). "The Treatment of Malignant Tumors by Repeated Innoculations of Erysipelas: With a Report of Ten Original Cases.". American Journal of the Medical Sciences 10: 487–511. 
  5. ^ a b "What is Coley’s toxins treatment for cancer?". Cancer Research UK. 22 August 2012. Retrieved April 2014. 
  6. ^ "Eminent Authority on Cancer and Abdominal Surgery, 74, Won Many Honors". New York Times. April 17, 1936. Retrieved 2010-11-22. "Dr. Coley died early yesterday morning in the Hospital for Ruptured and ... known as the Mixed Toxins of erysipelas and bacillus or Coley's Toxin. was found ..." 
  7. ^ New York Times: article on Pfizer and Coley Pharmaceutical Group, 5 October 2005
  8. ^ news-medical.net: Pfizer to acquire Coley Pharmaceutical Group, 19 November 2007
  9. ^ Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.

Further reading[edit]

  • Decker WK and Safdar S (2009) "Bioimmunoadjuvants for the treatment of neoplastic and infectious diseases: Coley's legacy revisited" Cytokine Growth Factor Rev. 20(4):271-81.
  • Donald HM. (2003) "Coley" Spontaneous Regression: Cancer and the Immune System Philadelphia: Xlibris. [1]
  • Hall, Steven S. (1997) A Commotion in the Blood. New York, New York: Henry Holt and Company. ISBN 0-8050-5841-9
  • Hess, David J. (1997) Can Bacteria Cause Cancer? Politics and Evaluation of Alternative Medicine. New York, New York: NYU Press.
  • Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.[2]
  • Hoption Cann SA, van Netten JP, van Netten C. (2003) "Dr William Coley and tumour regression: a place in history or in the future" Postgrad Med J 79 (938): 672–680 [3] [4] [5]
  • Hoption Cann SA, van Netten JP, van Netten C, Glover DW. (2002) "Spontaneous regression: a hidden treasure buried in time" Medical Hypotheses 58 (2): 115-119 [6] [7] [8]
  • Hoption Cann SA, Gunn HD, van Netten JP, van Netten C. (2004) "Spontaneous regression of pancreatic cancer" Case Rep Clin Pract Rev 293-296 [9] [10]
  • McCarthy, Edward F., MD, "The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas". Iowa Orthop J. 2006; 26: 154–158. [11]
  • Starnes, C. (1992) "Coley's Toxins in Perspective" Nature 357 (6373): 11-12.

External links[edit]

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