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Ch 1 of 12 "Coley's Toxins" - DVD Extra Clip from "Second Opinion: Laetrile At Sloan-Kettering"
Published: 2014/02/19
Channel: Second Opinion: Laetrile At Sloan-Kettering - Documentary
CURE FOR CANCER - Dr. William Coley
CURE FOR CANCER - Dr. William Coley's Fluid
Published: 2012/03/02
Channel: brainuter
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
Published: 2015/01/06
Channel: Cancer Research Institute
Coley
Coley's Toxins: The History Of The Worlds Most Powerful Cancer Treatment
Published: 2015/10/22
Channel: CHIPSA Hospital: Enhanced Gerson Therapy
Coley
Coley's Toxins
Published: 2012/07/27
Channel: Dr. Michael Johnson
2012 William B. Coley Award for Distinguished Research in Basic Immunology
2012 William B. Coley Award for Distinguished Research in Basic Immunology
Published: 2013/01/02
Channel: Cancer Research Institute
Drs. Chen, Freeman and Sharpe Accept the William B. Coley Award from the Cancer Research Institute
Drs. Chen, Freeman and Sharpe Accept the William B. Coley Award from the Cancer Research Institute
Published: 2015/11/17
Channel: Cancer Research Institute
Hayley Kiyoko - Girls Like Girls
Hayley Kiyoko - Girls Like Girls
Published: 2015/06/24
Channel: Hayley Kiyoko
My Soul Is Anchored by Douglas Miller
My Soul Is Anchored by Douglas Miller
Published: 2010/02/03
Channel: robbieatnsudotcom
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
Published: 2011/10/31
Channel: Cancer Research Institute
Meet the new Michael Johnson - William Coley
Meet the new Michael Johnson - William Coley
Published: 2012/06/03
Channel: damon coley
Outdated and overdue, lawmakers take on child support this week
Outdated and overdue, lawmakers take on child support this week
Published: 2017/10/16
Channel: NBC4 WCMH-TV Columbus
9-BA Daryl Coley Salute-2016-Mr. William (Bill) Bell
9-BA Daryl Coley Salute-2016-Mr. William (Bill) Bell
Published: 2016/04/09
Channel: rebecca matthews
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
Published: 2013/10/23
Channel: Cancer Research Institute
Cancer immunotherapy products from sugar, fat and protein - Professor Gavin Painter
Cancer immunotherapy products from sugar, fat and protein - Professor Gavin Painter
Published: 2016/04/20
Channel: Victoria University of Wellington
Fighting Cancer with Infection, 1891
Fighting Cancer with Infection, 1891
Published: 2016/04/08
Channel: The Scientist
Allen West refuses debate challenge from Muslims 4 Liberty National director
Allen West refuses debate challenge from Muslims 4 Liberty National director
Published: 2015/10/20
Channel: Farah Adam
Dr. James P. Allison Presents the William B. Coley Award to Drs. Chen, Freeman, Honjo and Sharpe
Dr. James P. Allison Presents the William B. Coley Award to Drs. Chen, Freeman, Honjo and Sharpe
Published: 2015/11/17
Channel: Cancer Research Institute
The Tatiana Show - Will Coley of Muslims for Liberty & Kingsley Edwards
The Tatiana Show - Will Coley of Muslims for Liberty & Kingsley Edwards
Published: 2017/08/18
Channel: Tatiana Moroz
3TC- William Coley halfpipe session
3TC- William Coley halfpipe session
Published: 2011/10/23
Channel: 3TCboards
3TC- William Coley shuvit rock-to-fakie
3TC- William Coley shuvit rock-to-fakie
Published: 2011/10/23
Channel: 3TCboards
3TC- William Coley kickflip rock-to-fakie 180
3TC- William Coley kickflip rock-to-fakie 180
Published: 2011/10/23
Channel: 3TCboards
Latest Movie New Sci fi Action Adveenture Moviees Fun ny
Latest Movie New Sci fi Action Adveenture Moviees Fun ny
Published: 2017/02/21
Channel: William Coley
Alexander Rudensky accepts the Coley Award
Alexander Rudensky accepts the Coley Award
Published: 2017/09/29
Channel: Cancer Research Institute
Wilmington Chester Mass Choir w/ Daryl Coley - "Sovereign"
Wilmington Chester Mass Choir w/ Daryl Coley - "Sovereign"
Published: 2008/02/18
Channel: FreLi77
Glenn Dranoff accepts the Coley Award
Glenn Dranoff accepts the Coley Award
Published: 2017/09/29
Channel: Cancer Research Institute
CRI Awards - Coley Award in Tumor Immunology
CRI Awards - Coley Award in Tumor Immunology
Published: 2013/05/17
Channel: Cancer Research Institute
New Science Fiction Alien Movies   Best Action Movies English Hollywood   New Sci Fi Movies HD
New Science Fiction Alien Movies Best Action Movies English Hollywood New Sci Fi Movies HD
Published: 2017/02/21
Channel: William Coley
Willy Wise vs Derrell Coley
Willy Wise vs Derrell Coley
Published: 2011/04/13
Channel: William Wise
First time
First time
Published: 2017/08/22
Channel: William Coley
Immunotherapy for Cancer - Coley Fluid - Gerson
Immunotherapy for Cancer - Coley Fluid - Gerson's diet
Published: 2009/03/22
Channel: Gar Hildenbrand
Vice President Nominations & Losing Pres. Candidate Speeches at 2016 Libertarian Natl. Conv., Part 1
Vice President Nominations & Losing Pres. Candidate Speeches at 2016 Libertarian Natl. Conv., Part 1
Published: 2016/08/08
Channel: LibertarianParty
Muslims 4 Liberty-TN confronts Carson on anti Islam rhetoric
Muslims 4 Liberty-TN confronts Carson on anti Islam rhetoric
Published: 2015/10/12
Channel: peachyashes1
Sov G Shiloh part 1
Sov G Shiloh part 1
Published: 2010/11/04
Channel: William Coley
Maniobras de Semiologia Dra. Gross
Maniobras de Semiologia Dra. Gross
Published: 2012/10/28
Channel: rodrigo gati
A Homework Hangout Proposal
A Homework Hangout Proposal
Published: 2014/02/14
Channel: EQSATUB
Daryl Coley "Beyond the Veil" @ Gospel Heritage Awards
Daryl Coley "Beyond the Veil" @ Gospel Heritage Awards
Published: 2013/06/17
Channel: Mo Phobe
Shiloh 3
Shiloh 3
Published: 2010/12/02
Channel: William Coley
May 2, 2016
May 2, 2016
Published: 2016/05/02
Channel: William Coley
DARYL COLEY - BEYOND THE VEIL
DARYL COLEY - BEYOND THE VEIL
Published: 2015/03/03
Channel: OpciónPositiva +music
Donald Lawrence - When Sunday Comes ft. Daryl Coley
Donald Lawrence - When Sunday Comes ft. Daryl Coley
Published: 2012/12/05
Channel: Randy Gadson
Wilmington Chester Mass Choir - Take It Away From Me [Feat. Darly Coley]
Wilmington Chester Mass Choir - Take It Away From Me [Feat. Darly Coley]
Published: 2012/03/18
Channel: onedadou1984
Young Coley - Ben (produced by David Duke)
Young Coley - Ben (produced by David Duke)
Published: 2012/01/05
Channel: william wyatt
Mo-Jo Madness
Mo-Jo Madness
Published: 2013/03/05
Channel: Paul Safrit
Playgoz Movie
Playgoz Movie
Published: 2011/02/14
Channel: William Coley
Maranda Willis - Nobody Like You Lord
Maranda Willis - Nobody Like You Lord
Published: 2015/06/16
Channel: SamuelMedasVEVO
jason statham 2017 ♛ english action movies ♛ sci fi movies 2017 #P2
jason statham 2017 ♛ english action movies ♛ sci fi movies 2017 #P2
Published: 2017/02/21
Channel: William Coley
Full Gospel Baptist Fellowship Mass Choir feat. Daryl Coley - The Giver
Full Gospel Baptist Fellowship Mass Choir feat. Daryl Coley - The Giver
Published: 2013/12/09
Channel: Trevon Dawson
The cure within us all
The cure within us all
Published: 2017/10/10
Channel: John Smith
William and Coley laughing and sitting up
William and Coley laughing and sitting up
Published: 2013/02/11
Channel: DanaBeth0923
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WIKIPEDIA ARTICLE

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William Bradley Coley
William Coley 1892.jpg
Born (1862-01-12)January 12, 1862
Westfield, Connecticut
Died April 16, 1936(1936-04-16) (aged 74)
New York City
Parent(s) Horace Bradley Coley
Clarina B. Wakeman

William Bradley Coley (January 12, 1862 – April 16, 1936) was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy.[1] He developed a treatment based on provoking an immune response to bacteria. In 1968 a protein related to his work was identified and called tumor necrosis factor-alpha.[2]

Biography[edit]

He was born on January 12, 1862 in Westfield, Connecticut to Horace Bradley Coley and Clarina B. Wakeman.

He began his career as a bone surgeon at New York Cancer Hospital (which later became part of the Memorial Sloan-Kettering Cancer Center); however, he became more interested in cancer treatment when one of his early patients, Elizabeth Dashiell,[3] died from bone cancer. While going through hospital records, Coley found a sarcoma case study of one patient named Fred Stein, whose tumor disappeared following a high fever from erysipelas infection, now known as Streptococcus pyogenes.[4] This sparked Coley's interest and drove him to find what few examples of similar cancer treatment had been previously recorded. He discovered that other medical pioneers including Robert Koch, Louis Pasteur, and Emil von Behring, had recorded observations of erysipelas infection coinciding with cancer regression.[citation needed]

From 1925 to 1933, Coley served as Surgeon-in-Chief of the Hospital for Special Surgery in New York City.[5]

Work on cancer and immune response[edit]

Coley developed the theory that post-surgical infections had helped patients to recover better from their cancer by provoking an immune response.[1] In 1891 he began to experiment by deliberately causing this phenomenon, injecting streptococcus bacteria directly into people being treated; later because this had the adverse effect of causing infection, he switched to using dead bacteria.[6][1] Coley published the results of his work as a case series, making it difficult to interpret them with confidence. According to the American Cancer Society, "More research would be needed to determine what benefit, if any, this therapy might have for people with cancer".[1] Cancer Research UK say that "available scientific evidence does not currently support claims that Coley's toxins can treat or prevent cancer".[7] People with cancer who take Coley's toxins alongside conventional cancer treatments, or who use it as a substitute for those treatments, risk seriously harming their health.[7]

Radiation therapy vs. Coley vaccine[edit]

By 1901, the development of x-rays as a cancer treatment showed great promise. In particular, the therapy resulted in immediate tumor destruction and pain relief. Although Coley claimed successful treatment of hundreds of patients, the absence of proven benefit or reproducibility led to broader emphasis on surgery and on the newly developing field of radiation therapy. This decision was borne out by the eventual successful treatment of millions of people worldwide with radiation therapy.[citation needed]

Coley arranged for a wealthy friend to provide funds to purchase two x-ray machines for his use. However, after several years of experience, Coley came to the conclusion that the effect of that primitive x-ray therapy in the untrained hands of experimenters was localized, temporary and not curative. The scientific majority disagreed, most notably his contemporary James Ewing. His contemporary critics cited the dangerous and unpredictable effects, predominantly the fever caused by the bacteria, that the vaccine had upon individuals weakened by cancer. Furthermore, the vaccine had to be made to a patient's exact needs, making it more labour-intensive, time-consuming and expensive.[citation needed]

Coley died on April 16, 1936.[8]

Legacy[edit]

In 2009, Coley's theory that immune systems in humans functioned in a cycle was demonstrated by a research team led by Associate Professor Brendon Coventry, which could have significant ramifications for cancer treatment.[9][10][11]

In 2005, drug makers including Pfizer and Sanofi-Aventis had a renewed interest in modern versions of Coley's Toxins;[12] Pfizer has acquired the Coley Pharmaceutical Group, set up in 1997.[13]

The historical results of Coley vaccine therapy are difficult to compare with modern results. Coley's studies were not well controlled and factors such as length of treatment and fever level were not adequately documented. Many of his patients had also received radiation and sometimes surgery. According to the analyses of Coley Nauts and Starnes, treatment success correlated with length of therapy and the fevers induced by the toxins.[14]

Coley's daughter, Helen Coley Nauts (1907–2001) established the nonprofit Cancer Research Institute in 1953 to study her father's work. The organization has since become a leader in funding research in immunology and tumor immunology at universities and hospitals worldwide.

See also[edit]

References[edit]

  1. ^ a b c d "Coley Toxins". American Cancer Society. 1 November 2008. Retrieved April 2014.  Check date values in: |access-date= (help)
  2. ^ Terlikowski SJ (2001). "Tumour necrosis factor and cancer treatment: a historical review and perspectives". Rocz. Akad. Med. Bialymst. 46: 5–18. PMID 11780579. 
  3. ^ Groopman, Jerome (2008). How Doctors Think. ISBN 978-0-547-05364-6. 
  4. ^ Coley WB (1893). "The Treatment of Malignant Tumors by Repeated Innoculations of Erysipelas: With a Report of Ten Original Cases.". American Journal of the Medical Sciences. 10: 487–511. 
  5. ^ Levine DB. The Hospital for the Ruptured and Crippled: William Bradley Coley, third surgeon-in-chief 1925–1933. J HSS 2007 Feb; 4(1):1-9.
  6. ^ theconversaion.com
  7. ^ a b "What is Coley’s toxins treatment for cancer?". Cancer Research UK. 22 August 2012. Retrieved April 2014.  Check date values in: |access-date= (help)
  8. ^ "Eminent Authority on Cancer and Abdominal Surgery, 74, Won Many Honors". New York Times. April 17, 1936. Retrieved 2010-11-22. Dr. Coley died early yesterday morning in the Hospital for Ruptured and ... known as the Mixed Toxins of erysipelas and bacillus or Coley's Toxin. was found ... 
  9. ^ http://www.australasianscience.com.au/article/issue-may-2010/matter-time.html
  10. ^ Coventry BJ, Ashdown ML, Quinn MA, Markovic SN, Yatomi-Clarke SL, Robinson AP, "CRP identifies homeostatic immune oscillations in cancer patients: potential treatment targeting tool?" Journal of Translational Medicine, 2009, 7: 102. Review.
  11. ^ Immunotherapy in the Twentieth Century: William Coley and Lloyd J. Old, CancerTherapyAdvisor.com, 15 March 2017
  12. ^ New York Times: article on Pfizer and Coley Pharmaceutical Group, 5 October 2005
  13. ^ news-medical.net: Pfizer to acquire Coley Pharmaceutical Group, 19 November 2007
  14. ^ Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.

Further reading[edit]

  • Decker WK and Safdar S (2009) "Bioimmunoadjuvants for the treatment of neoplastic and infectious diseases: Coley's legacy revisited" Cytokine Growth Factor Rev. 20(4):271-81.
  • Donald HM. (2003) "Coley" Spontaneous Regression: Cancer and the Immune System Philadelphia: Xlibris. [1]
  • Hall, Steven S. (1997) A Commotion in the Blood. New York, New York: Henry Holt and Company. ISBN 0-8050-5841-9
  • Hess, David J. (1997) Can Bacteria Cause Cancer? Politics and Evaluation of Alternative Medicine. New York, New York: NYU Press.
  • Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.[2]
  • Hoption Cann SA, van Netten JP, van Netten C. (2003) "Dr William Coley and tumour regression: a place in history or in the future" Postgrad Med J 79 (938): 672–680 [3] [4] [5]
  • Hoption Cann SA, van Netten JP, van Netten C, Glover DW. (2002) "Spontaneous regression: a hidden treasure buried in time" Medical Hypotheses 58 (2): 115-119 [6] [7] [8]
  • Hoption Cann SA, Gunn HD, van Netten JP, van Netten C. (2004) "Spontaneous regression of pancreatic cancer" Case Rep Clin Pract Rev 293-296 [9] [10]
  • McCarthy, Edward F., MD, "The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas". Iowa Orthop J. 2006; 26: 154–158. [11]
  • Starnes, C. (1992) "Coley's Toxins in Perspective" Nature 357 (6373): 11-12.

External links[edit]

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