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The History of Coley
The History of Coley's Toxins
Published: 2015/10/22
Channel: CHIPSA Hospital: Enhanced Gerson Therapy
Ch 1 of 12 "Coley
Ch 1 of 12 "Coley's Toxins" - DVD Extra Clip from "Second Opinion: Laetrile At Sloan-Kettering"
Published: 2014/02/19
Channel: Second Opinion: Laetrile At Sloan-Kettering - Documentary
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
Published: 2015/01/06
Channel: Cancer Research Institute
CURE FOR CANCER - Dr. William Coley
CURE FOR CANCER - Dr. William Coley's Fluid
Published: 2012/03/02
Channel: brainuter
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
Published: 2011/10/31
Channel: Cancer Research Institute
Fighting Cancer with Infection, 1891
Fighting Cancer with Infection, 1891
Published: 2016/04/08
Channel: The Scientist
2012 William B. Coley Award for Distinguished Research in Basic Immunology
2012 William B. Coley Award for Distinguished Research in Basic Immunology
Published: 2013/01/02
Channel: Cancer Research Institute
CRI Awards - Coley Award in Tumor Immunology
CRI Awards - Coley Award in Tumor Immunology
Published: 2013/05/17
Channel: Cancer Research Institute
Drs. Chen, Freeman and Sharpe Accept the William B. Coley Award from the Cancer Research Institute
Drs. Chen, Freeman and Sharpe Accept the William B. Coley Award from the Cancer Research Institute
Published: 2015/11/17
Channel: Cancer Research Institute
Coley
Coley's Toxins
Published: 2012/07/27
Channel: Dr. Michael Johnson
Engineering T cells: moving beyond leukemia
Engineering T cells: moving beyond leukemia
Published: 2016/10/18
Channel: nihvcast
Blood found in parking lot where nurse went missing
Blood found in parking lot where nurse went missing
Published: 2017/12/08
Channel: Hollywood TV
New Hindi Dubbed Movies 2016 Best Sci Fi Movies 2016 New Hindi Movies
New Hindi Dubbed Movies 2016 Best Sci Fi Movies 2016 New Hindi Movies
Published: 2017/02/21
Channel: William Coley
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
Published: 2013/10/23
Channel: Cancer Research Institute
3TC- William Coley halfpipe session
3TC- William Coley halfpipe session
Published: 2011/10/23
Channel: 3TCboards
#KylerStrong Foundation donates $46K to Cancer research in boy
#KylerStrong Foundation donates $46K to Cancer research in boy's memory
Published: 2018/02/01
Channel: LOCAL 12
Meet the new Michael Johnson - William Coley
Meet the new Michael Johnson - William Coley
Published: 2012/06/03
Channel: damon coley
Dr. James P. Allison Presents the William B. Coley Award to Drs. Chen, Freeman, Honjo and Sharpe
Dr. James P. Allison Presents the William B. Coley Award to Drs. Chen, Freeman, Honjo and Sharpe
Published: 2015/11/17
Channel: Cancer Research Institute
Hyperthermia is dangerous Avoid it
Hyperthermia is dangerous Avoid it
Published: 2015/11/02
Channel: Gershom Zajicek M.D,
November 16, 2017
November 16, 2017
Published: 2017/11/16
Channel: William Coley
3TC- William Coley shuvit rock-to-fakie
3TC- William Coley shuvit rock-to-fakie
Published: 2011/10/23
Channel: 3TCboards
3TC- William Coley kickflip rock-to-fakie 180
3TC- William Coley kickflip rock-to-fakie 180
Published: 2011/10/23
Channel: 3TCboards
Phil Greenberg presents the Coley Award to Alexander Rudensky
Phil Greenberg presents the Coley Award to Alexander Rudensky
Published: 2018/02/05
Channel: Cancer Research Institute
NLD Gingivectomy
NLD Gingivectomy
Published: 2012/07/11
Channel: nextleveldental
Immunotherapy for Cancer - Coley Fluid - Gerson
Immunotherapy for Cancer - Coley Fluid - Gerson's diet
Published: 2009/03/22
Channel: Gar Hildenbrand
Outdated and overdue, lawmakers take on child support this week
Outdated and overdue, lawmakers take on child support this week
Published: 2017/10/16
Channel: NBC4 WCMH-TV Columbus
Original Coleys Toxins Opening | Ralph Moss | Eric Merola
Original Coleys Toxins Opening | Ralph Moss | Eric Merola
Published: 2015/01/05
Channel: Eric Merola Films
First time
First time
Published: 2017/08/22
Channel: William Coley
Dr. Coley Interview
Dr. Coley Interview
Published: 2013/07/29
Channel: Bryce Hantla
Cancer immunotherapy products from sugar, fat and protein - Professor Gavin Painter
Cancer immunotherapy products from sugar, fat and protein - Professor Gavin Painter
Published: 2016/04/20
Channel: Victoria University of Wellington
My Nikkah!!
My Nikkah!!
Published: 2009/02/19
Channel: orlandoprotestsgaza
dare devil boys-free running dos
dare devil boys-free running dos
Published: 2012/08/19
Channel: damon coley
Mit Immunzellen gegen Krebs
Mit Immunzellen gegen Krebs
Published: 2012/08/20
Channel: Spektrum der Wissenschaft
William and Coley laughing and sitting up
William and Coley laughing and sitting up
Published: 2013/02/11
Channel: DanaBeth0923
Maniobras de Semiologia Dra. Gross
Maniobras de Semiologia Dra. Gross
Published: 2012/10/28
Channel: rodrigo gati
2013 Cancer Research Institute Awards Dinner highlights
2013 Cancer Research Institute Awards Dinner highlights
Published: 2013/11/26
Channel: Cancer Research Institute
A Homework Hangout Proposal
A Homework Hangout Proposal
Published: 2014/02/14
Channel: EQSATUB
Dr. Coley Interview 2
Dr. Coley Interview 2
Published: 2013/07/29
Channel: Bryce Hantla
The Tatiana Show - Will Coley of Muslims for Liberty & Kingsley Edwards
The Tatiana Show - Will Coley of Muslims for Liberty & Kingsley Edwards
Published: 2017/08/18
Channel: Tatiana Moroz
Cancer Research Institute 60th Anniversary Awards Dinner: Welcome by John Fitzgibbons
Cancer Research Institute 60th Anniversary Awards Dinner: Welcome by John Fitzgibbons
Published: 2013/10/23
Channel: Cancer Research Institute
9-BA Daryl Coley Salute-2016-Mr. William (Bill) Bell
9-BA Daryl Coley Salute-2016-Mr. William (Bill) Bell
Published: 2016/04/09
Channel: rebecca matthews
Mike Francis SRP
Mike Francis SRP
Published: 2010/10/27
Channel: William Coley
Q&A March 30, 2017
Q&A March 30, 2017
Published: 2017/03/31
Channel: Bailey O'Brien
Shiloh 2
Shiloh 2
Published: 2010/11/25
Channel: William Coley
Sov G Shiloh part 1
Sov G Shiloh part 1
Published: 2010/11/04
Channel: William Coley
THE COLEY
THE COLEY'S
Published: 2013/11/15
Channel: Takita Coley
My Cancer Treatments - Coley
My Cancer Treatments - Coley's Toxin at CHIPSA Immunotherapy Hospital in Tijuana, Mexico
Published: 2018/02/01
Channel: Matthew John Armstrong
MENDEL LECTURES / Shizuo Akira / Functional Diversity of Macrophage/Monocyte Subsets / 19.10.2017
MENDEL LECTURES / Shizuo Akira / Functional Diversity of Macrophage/Monocyte Subsets / 19.10.2017
Published: 2017/10/23
Channel: MENDEL LECTURES
Playgoz Movie
Playgoz Movie
Published: 2011/02/14
Channel: William Coley
May 2, 2016
May 2, 2016
Published: 2016/05/02
Channel: William Coley
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WIKIPEDIA ARTICLE

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William Bradley Coley
William Coley 1892.jpg
Born (1862-01-12)January 12, 1862
Westfield, Connecticut
Died April 16, 1936(1936-04-16) (aged 74)
New York City
Parent(s) Horace Bradley Coley
Clarina B. Wakeman

William Bradley Coley (January 12, 1862 – April 16, 1936) was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy.[1] He developed a treatment based on provoking an immune response to bacteria. In 1968 a protein related to his work was identified and called tumor necrosis factor-alpha.[2]

Biography[edit]

He was born on January 12, 1862 in Westfield, Connecticut to Horace Bradley Coley and Clarina B. Wakeman.

He began his career as a bone surgeon at New York Cancer Hospital (which later became part of the Memorial Sloan-Kettering Cancer Center); however, he became more interested in cancer treatment when one of his early patients, Elizabeth Dashiell,[3] died from bone cancer. While going through hospital records, Coley found a sarcoma case study of one patient named Fred Stein, whose tumor disappeared following a high fever from erysipelas infection, now known as Streptococcus pyogenes.[4] This sparked Coley's interest and drove him to find what few examples of similar cancer treatment had been previously recorded.[5][6] He discovered that other medical pioneers including Robert Koch, Louis Pasteur, and Emil von Behring, had recorded observations of erysipelas infection coinciding with cancer regression.[citation needed]

From 1925 to 1933, Coley served as Surgeon-in-Chief of the Hospital for Special Surgery in New York City.[7]

Work on cancer and immune response[edit]

Coley developed the theory that post-surgical infections had helped patients to recover better from their cancer by provoking an immune response.[1] In 1891 he began to experiment by deliberately causing this phenomenon, injecting streptococcus bacteria directly into people being treated; later because this had the adverse effect of causing infection, he switched to using dead bacteria.[8][1] Coley published the results of his work as a case series, making it difficult to interpret them with confidence. According to the American Cancer Society, "More research would be needed to determine what benefit, if any, this therapy might have for people with cancer".[1] Cancer Research UK say that "available scientific evidence does not currently support claims that Coley's toxins can treat or prevent cancer".[9] People with cancer who take Coley's toxins alongside conventional cancer treatments, or who use it as a substitute for those treatments, risk seriously harming their health.[9]

Radiation therapy vs. Coley vaccine[edit]

By 1901, the development of x-rays as a cancer treatment showed great promise. In particular, the therapy resulted in immediate tumor destruction and pain relief. Although Coley claimed successful treatment of hundreds of patients, the absence of proven benefit or reproducibility led to broader emphasis on surgery and on the newly developing field of radiation therapy. This decision was borne out by the eventual successful treatment of millions of people worldwide with radiation therapy.[citation needed]

Coley arranged for a wealthy friend to provide funds to purchase two x-ray machines for his use. However, after several years of experience, Coley came to the conclusion that the effect of that primitive x-ray therapy in the untrained hands of experimenters was localized, temporary and not curative. The scientific majority disagreed, most notably his contemporary James Ewing. His contemporary critics cited the dangerous and unpredictable effects, predominantly the fever caused by the bacteria, that the vaccine had upon individuals weakened by cancer. Furthermore, the vaccine had to be made to a patient's exact needs, making it more labour-intensive, time-consuming and expensive.[citation needed]

Coley died on April 16, 1936.[10]

Legacy[edit]

In 2009, Coley's theory that immune systems in humans functioned in a cycle was demonstrated by a research team led by Associate Professor Brendon Coventry, which could have significant ramifications for cancer treatment.[11][12][13]

In 2005, drug makers including Pfizer and Sanofi-Aventis had a renewed interest in modern versions of Coley's Toxins;[14] Pfizer has acquired the Coley Pharmaceutical Group, set up in 1997.[15]

The historical results of Coley vaccine therapy are difficult to compare with modern results. Coley's studies were not well controlled and factors such as length of treatment and fever level were not adequately documented. Many of his patients had also received radiation and sometimes surgery. According to the analyses of Coley Nauts and Starnes, treatment success correlated with length of therapy and the fevers induced by the toxins.[16]

Coley's daughter, Helen Coley Nauts (1907–2001) established the nonprofit Cancer Research Institute in 1953 to study her father's work. The organization has since become a leader in funding research in immunology and tumor immunology at universities and hospitals worldwide.

See also[edit]

References[edit]

  1. ^ a b c d "Coley Toxins". American Cancer Society. 1 November 2008. Retrieved April 2014.  Check date values in: |access-date= (help)
  2. ^ Terlikowski SJ (2001). "Tumour necrosis factor and cancer treatment: a historical review and perspectives". Rocz. Akad. Med. Bialymst. 46: 5–18. PMID 11780579. 
  3. ^ Groopman, Jerome (2008). How Doctors Think. ISBN 978-0-547-05364-6. 
  4. ^ Coley WB (1893). "The Treatment of Malignant Tumors by Repeated Innoculations of Erysipelas: With a Report of Ten Original Cases". American Journal of the Medical Sciences. 10: 487–511. 
  5. ^ That erysipelas could cause cancerous tumors to regress was known at least as early as the 1860s. See:
    • Tanner, Thomas Hawkes (1863). "A clinical report on cancer of the female sexual organs". The British and Foreign Medico-chirurgical Review, …. 32: 151–153.  On p. 152, Tanner noted that the French surgeon Alfred-Armand-Louis-Marie Velpeau had been unusually successful in treating cancers: " … the only difference [that] he [viz, Tanner] can discover "between M. Velpeau's cases and those of other surgeons is this, that a much larger number of them suffered from erysipelas after the operation of excision than commonly happens." "
    • Collins, Maurice Henry (1864). On the Diagnosis and Treatment of Cancer and the Tumours Analogous to It. London, England: John Churchill and Sons. pp. 150–152.  From p. 150: "With regard to the effect of erysipelas, a strange notion has existed in the minds of several independent observers. … It is that erysipelas is antagonistic to cancer; when a patient recovers from a severe attack of erysipelas after removal of the cancerous part, she is more safe from relapse." Collins then cites cases of "Mr. Tanner" and "Mr. Smyly".
    • The German surgeon Wilhelm Busch observed cases in which erysipelas caused regression of tumors:
    • (Editorial staff) (4 June 1866). "Niederrheinische Gesellschaft für Natur- und Heilkunde in Bonn. Aus der Sitzung der medicinischen Section vom 14. März 1866" [Lower Rhine Society for Science and Medicine in Bonn. From the session of the medical section on 14 March 1866]. Berliner klinische Wochenschrift (Berlin Clinical Weekly Journal) (in German). 3 (23): 245–246.  From p. 245: "Prof. Busch bespricht den Einfluss, welchen heftige Erysipele zuweilen auf organisirte Neubilden ausüben." (Prof. Busch discussed the influence which severe erysipelas sometimes exerts on organized new formations [i.e., new malignancies in the lymphatic glands].)
    • (Editorial staff) (23 March 1868). "Niederrheinische Gesellschaft für Natur- und Heilkunde in Bonn. Aus der Sitzung der medicinischen Section vom 13. November 1867" [Lower Rhine Society for Science and Medicine in Bonn. From the session of the medical section on 13 November 1867]. Berliner klinische Wochenschrift (Berlin Clinical Weekly Journal) (in German). 5 (12): 137–138.  From p. 137: "Prof. Busch theilt eine neue Beobachtung über den Einfluss mit, welchen heftige Erysipele auf die Rückbildung von Geschwülsten haben, die hauptsächlich aus zelligen Wucherungen bestehen. In der Sitzung vom 14. März 1866 hatte er die ihm zu Gebote stehende Beobachtungen besprochen, bei welchen zufällig entstandene Erysipele eine Resorption der zelligen Massen ohne Eiterung hervorgebracht hatten." (Prof. Busch reported a new observation of the influence which severe erysipelas has on the regression of tumors, which mainly arise from cellular proliferation. In the session of 14 March 1866, he had discussed the observations that were at his disposal, in which cases erysipelas that had arisen incidentally had brought about a resorption of the cellular masses without suppuration.)
    • Volkmann, Richard (1869). "Erysipelas, Rose, Rothlauf". In Pitha, Franz von; Billroth, Theodor. Handbuch der allgemeinen und speciellen Chirurgie … (in German). vol. 1, pt. 2. Erlangen, (Germany): Enke. pp. 128–186.  From pp. 173-174: "§. 177. Zum Schluss muss ich noch dem höchst eigenthümlichen Einfluss erwähnen, den intercurrente Erysipele zuweilen auf die rasche Resorption entzündlich gewucherter oder indurirter Gewebe und selbst eigentlicher Geschwülste haben." (§. 177. In conclusion, I must mention the most strange influence that intercurrent erysipelas sometimes has on the sudden resorption of tissues that proliferated by inflammation or hardened and even of actual tumors.)
    • Lücke, Albert (1869). Handbuch der allgemeinen und speciellen Chirurgie … : Die Lehre von den Geschwülsten in anatomischer und klinischer Beziehung [Handbook of General and Special Surgery … : The science of tumors in their anatomical and clinical aspects] (in German). vol. 2, pt. 1. Erlangen, (Germany): Ferdinand Enke. p. 31.  From p. 31: "Auch Erysipelas in den verschiedensten Formen und Graden kann von der gesunden Haut ausgehend in den Geschwülsten Eiterung, Zerfall und Verjauchung erzeugen." (Also erysipelas in its most varied forms and degrees can cause – from the healthy skin to the tumor – suppuration, disaggregation, and putrefaction.)
    • Fehleisen, Friedrich (1883). Die Aetiologie des Erysipels (in German). Berlin, Germany: Theodor Fischer. p. 20.  From p. 20: "Die ersten Angaben über die Heilwirkung des Erysipels stammen aus dem 17. Jahrhundert. … ganz unbestreitbar ist endlich die Thatsache, dass manche Geschwülste durch ein Erysipel zum Verschwinden gebracht worden sind." (The first indications about the healing effects of erysipelas come from the 17th century. … finally quite indisputable is the fact that some tumors have been made to vanish by erysipelas.)
  6. ^ Bainbridge, William Seaman (1914). The Cancer Problem. New York, New York, USA: Macmillan Co. pp. 333–334. 
  7. ^ Levine DB. The Hospital for the Ruptured and Crippled: William Bradley Coley, third surgeon-in-chief 1925–1933. J HSS 2007 Feb; 4(1):1-9.
  8. ^ theconversaion.com
  9. ^ a b "What is Coley's toxins treatment for cancer?". Cancer Research UK. 22 August 2012. Retrieved April 2014.  Check date values in: |access-date= (help)
  10. ^ "Eminent Authority on Cancer and Abdominal Surgery, 74, Won Many Honors". New York Times. April 17, 1936. Retrieved 2010-11-22. Dr. Coley died early yesterday morning in the Hospital for Ruptured and ... known as the Mixed Toxins of erysipelas and bacillus or Coley's Toxin. was found ... 
  11. ^ http://www.australasianscience.com.au/article/issue-may-2010/matter-time.html
  12. ^ Coventry BJ, Ashdown ML, Quinn MA, Markovic SN, Yatomi-Clarke SL, Robinson AP, "CRP identifies homeostatic immune oscillations in cancer patients: potential treatment targeting tool?" Journal of Translational Medicine, 2009, 7: 102. Review.
  13. ^ Immunotherapy in the Twentieth Century: William Coley and Lloyd J. Old, CancerTherapyAdvisor.com, 15 March 2017
  14. ^ New York Times: article on Pfizer and Coley Pharmaceutical Group, 5 October 2005
  15. ^ news-medical.net: Pfizer to acquire Coley Pharmaceutical Group, 19 November 2007
  16. ^ Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.

Further reading[edit]

  • Decker WK and Safdar S (2009) "Bioimmunoadjuvants for the treatment of neoplastic and infectious diseases: Coley's legacy revisited" Cytokine Growth Factor Rev. 20(4):271-81.
  • Donald HM. (2003) "Coley" Spontaneous Regression: Cancer and the Immune System Philadelphia: Xlibris[self-published source]. [1]
  • Hall, Steven S. (1997) A Commotion in the Blood. New York, New York: Henry Holt and Company. ISBN 0-8050-5841-9
  • Hess, David J. (1997) Can Bacteria Cause Cancer? Politics and Evaluation of Alternative Medicine. New York, New York: NYU Press.
  • Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.[2]
  • Hoption Cann SA, van Netten JP, van Netten C. (2003) "Dr William Coley and tumour regression: a place in history or in the future" Postgrad Med J 79 (938): 672–680 [3] [4] [5]
  • Hoption Cann SA, van Netten JP, van Netten C, Glover DW. (2002) "Spontaneous regression: a hidden treasure buried in time" Medical Hypotheses 58 (2): 115-119 [6] [7] [8]
  • Hoption Cann SA, Gunn HD, van Netten JP, van Netten C. (2004) "Spontaneous regression of pancreatic cancer" Case Rep Clin Pract Rev 293-296 [9] [10]
  • McCarthy, Edward F., MD, "The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas". Iowa Orthop J. 2006; 26: 154–158. [11]
  • Starnes, C. (1992) "Coley's Toxins in Perspective" Nature 357 (6373): 11-12.

External links[edit]

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