1
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
Discovering the PD-1 Checkpoint: Winners of the 2014 William B. Coley Award for Tumor Immunology
DATE: 2015/01/06::
2
CURE FOR CANCER - Dr. William Coley
CURE FOR CANCER - Dr. William Coley's Fluid
DATE: 2012/03/01::
3
2012 William B. Coley Award for Distinguished Research in Basic Immunology
2012 William B. Coley Award for Distinguished Research in Basic Immunology
DATE: 2013/01/02::
4
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
Dr. Glenn Dranoff Presents the 2013 William B. Coley Award to Dr. Michael Karin
DATE: 2013/10/23::
5
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
CRI 25th Annual Awards Dinner: William B. Coley Award for Distinguished Research in Tumor Immunology
DATE: 2011/10/30::
6
Immunotherapy for Cancer - Coley Fluid - Gerson
Immunotherapy for Cancer - Coley Fluid - Gerson's diet
DATE: 2009/03/22::
7
Meet the new Michael Johnson - William Coley
Meet the new Michael Johnson - William Coley
DATE: 2012/06/03::
8
3TC- William Coley halfpipe session
3TC- William Coley halfpipe session
DATE: 2011/10/23::
9
3TC- William Coley shuvit rock-to-fakie
3TC- William Coley shuvit rock-to-fakie
DATE: 2011/10/22::
10
3TC- William Coley kickflip rock-to-fakie 180
3TC- William Coley kickflip rock-to-fakie 180
DATE: 2011/10/22::
11
CRI Awards - Coley Award in Tumor Immunology
CRI Awards - Coley Award in Tumor Immunology
DATE: 2013/05/17::
12
William and Coley laughing and sitting up
William and Coley laughing and sitting up
DATE: 2013/02/10::
13
2013 Cancer Research Institute Awards Dinner highlights
2013 Cancer Research Institute Awards Dinner highlights
DATE: 2013/11/26::
14
Willy Wise vs Derrell Coley
Willy Wise vs Derrell Coley
DATE: 2011/04/13::
15
DERRELL COLEY - DOMINIQUE WADE IS BETTER THAN WHO????
DERRELL COLEY - DOMINIQUE WADE IS BETTER THAN WHO????
DATE: 2014/07/01::
16
Cancer Research Institute 60th Anniversary Awards Dinner: Welcome by John Fitzgibbons
Cancer Research Institute 60th Anniversary Awards Dinner: Welcome by John Fitzgibbons
DATE: 2013/10/23::
17
Daryl Coley
Daryl Coley
DATE: 2008/04/27::
18
dare devil boys-free running dos
dare devil boys-free running dos
DATE: 2012/08/19::
19
Young Coley - Ben (produced by David Duke)
Young Coley - Ben (produced by David Duke)
DATE: 2012/01/05::
20
Mike Francis SRP
Mike Francis SRP
DATE: 2010/10/27::
21
Edward Coley Burne Jones I
Edward Coley Burne Jones I
DATE: 2011/02/26::
22
Never Let You Down- Daryl Coley
Never Let You Down- Daryl Coley
DATE: 2013/02/03::
23
DERRELL COLEY - CMON THOMAS "TOP DOG" WILLIAMS... #coleysaidit
DERRELL COLEY - CMON THOMAS "TOP DOG" WILLIAMS... #coleysaidit
DATE: 2014/08/06::
24
Edward Coley Burne Jones II -  Cycles
Edward Coley Burne Jones II - Cycles
DATE: 2011/02/26::
25
Kyle Coley
Kyle Coley's 11 Minutes of Stand-up
DATE: 2012/10/16::
26
Dad Coley
Dad Coley's Tribute ... Bishop Willis
DATE: 2013/02/02::
27
William Whitaker Tribute
William Whitaker Tribute
DATE: 2008/05/23::
28
Metamorphosis, I. Zippo Lighter by Brett William Dietz
Metamorphosis, I. Zippo Lighter by Brett William Dietz
DATE: 2010/05/31::
29
Im gonna make you love me f. Young Coley and David Duke
Im gonna make you love me f. Young Coley and David Duke
DATE: 2011/03/28::
30
Metamorphosis; II. Walking Bass by Brett William Dietz
Metamorphosis; II. Walking Bass by Brett William Dietz
DATE: 2010/05/31::
31
He Can Work It Out
He Can Work It Out
DATE: 2014/11/08::
32
Madden 25 Career Season 1 - William "The Refridgerator" Perry RB - Preseason game 1
Madden 25 Career Season 1 - William "The Refridgerator" Perry RB - Preseason game 1
DATE: 2013/10/05::
33
Dare Devil Boys - Free Running
Dare Devil Boys - Free Running
DATE: 2012/08/19::
34
Daryl Coley - Don
Daryl Coley - Don't Give Up On Jesus (feat. Vanessa Bell Armstrong)
DATE: 2010/04/07::
35
Joleon Lescott - Ice Bucket Challenge - Nominates Richards , Ash Coley and other
Joleon Lescott - Ice Bucket Challenge - Nominates Richards , Ash Coley and other
DATE: 2014/08/18::
36
Бой между Ievgen Khytrov vs Aaron Coley в отличном качестве
Бой между Ievgen Khytrov vs Aaron Coley в отличном качестве
DATE: 2015/04/11::
37
Excellence in Action 2009 - An 8-Track Tape Deck in an iPod World
Excellence in Action 2009 - An 8-Track Tape Deck in an iPod World
DATE: 2012/07/29::
38
Muestras Hierro Nodular
Muestras Hierro Nodular
DATE: 2007/07/06::
39
Douglas Miller-My Soul Has Been Anchored In The Lord
Douglas Miller-My Soul Has Been Anchored In The Lord
DATE: 2012/04/23::
40
Daryl Coley "I
Daryl Coley "I'll Be With You" (1988)
DATE: 2014/06/01::
41
DARYL COLEY - II CHRONICLES
DARYL COLEY - II CHRONICLES
DATE: 2013/10/22::
42
Full Gospel Baptist Fellowship Mass Choir feat. Daryl Coley - The Giver
Full Gospel Baptist Fellowship Mass Choir feat. Daryl Coley - The Giver
DATE: 2013/12/08::
43
Daryl Coley  "Hallelujah You
Daryl Coley "Hallelujah You're Worthy"
DATE: 2010/12/11::
44
Daryl Coley Jesus never fails
Daryl Coley Jesus never fails
DATE: 2012/03/21::
45
Ch 1 of 12 "Coley
Ch 1 of 12 "Coley's Toxins" - DVD Extra Clip from "Second Opinion: Laetrile At Sloan-Kettering"
DATE: 2014/02/19::
46
He That Dwelleth(Psalm 91) Daryl Coley
He That Dwelleth(Psalm 91) Daryl Coley
DATE: 2008/08/16::
47
DARYL COLEY - SOVEREIGN(SLOWJAM GOSPEL VIDEO)REARRANGED(IN C# MAJOR)
DARYL COLEY - SOVEREIGN(SLOWJAM GOSPEL VIDEO)REARRANGED(IN C# MAJOR)
DATE: 2013/01/04::
48
Daryl Coley- In the arms of Jesus
Daryl Coley- In the arms of Jesus
DATE: 2011/06/07::
49
DARYL COLEY...JESUS SAVES
DARYL COLEY...JESUS SAVES
DATE: 2011/07/28::
50
Anthology of American Folk Music (Full)
Anthology of American Folk Music (Full)
DATE: 2014/11/28::
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From Wikipedia, the free encyclopedia
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William Bradley Coley
William Coley 1892.jpg
Born (1862-01-12)January 12, 1862
Westfield, Connecticut
Died April 16, 1936(1936-04-16) (aged 74)
Parent(s) Horace Bradley Coley
Clarina B. Wakeman

William Bradley Coley (January 12, 1862 – April 16, 1936) was an American bone surgeon and cancer researcher, pioneer of cancer immunotherapy.[1] He developed a treatment based on provoking an immune response to bacteria. In 1968 a protein related to his work was identified and called tumor necrosis factor-alpha.[2]

Biography[edit]

He was born on January 12, 1862 in Westfield, Connecticut to Horace Bradley Coley and Clarina B. Wakeman.

He began his career as a bone surgeon at New York Cancer Hospital (which later became part of the Memorial Sloan-Kettering Cancer Center); however, he became more interested in cancer treatment when one of his early patients, Elizabeth Dashiell,[3] died from bone cancer. While going through hospital records, Coley found a sarcoma case study of one patient named Fred Stein, whose tumor disappeared following a high fever from erysipelas infection, now known as Streptococcus pyogenes.[4] This sparked Coley's interest and drove him to find what few examples of similar cancer treatment had been previously recorded. He discovered that other medical pioneers including Robert Koch, Louis Pasteur, and Emil von Behring, had recorded observations of erysipelas infection coinciding with cancer regression.[citation needed]

Work on cancer and immune response[edit]

Main article: Coley's toxins

Coley developed the theory that post-surgical infections had helped patients to recover better from their cancer by provoking an immune response.[1] He began to experiment by deliberately causing this phenomenon, injecting bacteria directly into people being treated – but because this had the adverse effect of causing infection he then switched to using dead bacteria.[1] Coley published the results of his work as a case series, making it difficult to interpret them with confidence. According to the American Cancer Society, "more research would be needed to determine what benefit, if any, this therapy might have for people with cancer".[1] Cancer Research UK say that "available scientific evidence does not currently support claims that Coley's toxins can treat or prevent cancer".[5] People with cancer who take Coley's toxins alongside conventional cancer treatments, or who use it as a substitute for those treatments, risk seriously harming their health.[5]

Radiation therapy vs. Coley vaccine[edit]

By 1901, the development of x-rays as a cancer treatment showed great promise. In particular, the therapy resulted in immediate tumor destruction and pain relief. Although Coley claimed successful treatment of hundreds of patients, the absence of proven benefit or reproducibility led to broader emphasis on surgery and on the newly developing field of radiation therapy. This decision was borne out by the eventual successful treatment of millions of people worldwide with radiation therapy.[citation needed]

Coley arranged for a wealthy friend to provide funds to purchase two x-ray machines for his use. However, after several years of experience, Coley came to the conclusion that the effect of that primitive x-ray therapy in the untrained hands of experimenters was localized, temporary and not curative. The scientific majority disagreed, most notably his contemporary James Ewing. His contemporary critics cited the dangerous and unpredictable effects, predominantly the fever caused by the bacteria, that the vaccine had upon individuals weakened by cancer. Furthermore the vaccine had to be made to a patient's exact needs, making it more labour-intensive, time-consuming and expensive.[citation needed]

Coley died on April 16, 1936.[6]

Legacy[edit]

In 2005, drug makers including Pfizer and Sanofi-Aventis had a renewed interest in modern versions of Coley's Toxins;[7] Pfizer has acquired the Coley Pharmaceutical Group, set up in 1997[8]

The historical results of Coley vaccine therapy are difficult to compare with modern results. Coley's studies were not well controlled and factors such as length of treatment and fever level were not adequately documented. Many of his patients had also received radiation and sometimes surgery. According to the analyses of Coley Nauts and Starnes, treatment success correlated with length of therapy and the fevers induced by the toxins.[9]

Coley's daughter, Helen Coley Nauts, established the nonprofit Cancer Research Institute in 1953 to study her father's work. The organization has since become a leader in funding research in immunology and tumor immunology at universities and hospitals worldwide.

See also[edit]

References[edit]

  1. ^ a b c d "Coley Toxins". American Cancer Society. 1 November 2008. Retrieved April 2014. 
  2. ^ Terlikowski SJ (2001). "Tumour necrosis factor and cancer treatment: a historical review and perspectives". Rocz. Akad. Med. Bialymst. 46: 5–18. PMID 11780579. 
  3. ^ Groopman, Jerome (2008). How Doctors Think. ISBN 978-0-547-05364-6. 
  4. ^ Coley WB (1893). "The Treatment of Malignant Tumors by Repeated Innoculations of Erysipelas: With a Report of Ten Original Cases.". American Journal of the Medical Sciences 10: 487–511. 
  5. ^ a b "What is Coley’s toxins treatment for cancer?". Cancer Research UK. 22 August 2012. Retrieved April 2014. 
  6. ^ "Eminent Authority on Cancer and Abdominal Surgery, 74, Won Many Honors". New York Times. April 17, 1936. Retrieved 2010-11-22. Dr. Coley died early yesterday morning in the Hospital for Ruptured and ... known as the Mixed Toxins of erysipelas and bacillus or Coley's Toxin. was found ... 
  7. ^ New York Times: article on Pfizer and Coley Pharmaceutical Group, 5 October 2005
  8. ^ news-medical.net: Pfizer to acquire Coley Pharmaceutical Group, 19 November 2007
  9. ^ Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.

Further reading[edit]

  • Decker WK and Safdar S (2009) "Bioimmunoadjuvants for the treatment of neoplastic and infectious diseases: Coley's legacy revisited" Cytokine Growth Factor Rev. 20(4):271-81.
  • Donald HM. (2003) "Coley" Spontaneous Regression: Cancer and the Immune System Philadelphia: Xlibris. [1]
  • Hall, Steven S. (1997) A Commotion in the Blood. New York, New York: Henry Holt and Company. ISBN 0-8050-5841-9
  • Hess, David J. (1997) Can Bacteria Cause Cancer? Politics and Evaluation of Alternative Medicine. New York, New York: NYU Press.
  • Hobohm, Uwe (January - February 2009). "Healing Heat: Harnessing Infection to Fight Cancer" American Scientist 97 (1): 34-41.[2]
  • Hoption Cann SA, van Netten JP, van Netten C. (2003) "Dr William Coley and tumour regression: a place in history or in the future" Postgrad Med J 79 (938): 672–680 [3] [4] [5]
  • Hoption Cann SA, van Netten JP, van Netten C, Glover DW. (2002) "Spontaneous regression: a hidden treasure buried in time" Medical Hypotheses 58 (2): 115-119 [6] [7] [8]
  • Hoption Cann SA, Gunn HD, van Netten JP, van Netten C. (2004) "Spontaneous regression of pancreatic cancer" Case Rep Clin Pract Rev 293-296 [9] [10]
  • McCarthy, Edward F., MD, "The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas". Iowa Orthop J. 2006; 26: 154–158. [11]
  • Starnes, C. (1992) "Coley's Toxins in Perspective" Nature 357 (6373): 11-12.

External links[edit]

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